公开(公告)号：US20080027115A1

公开(公告)日：2008-01-31

申请号：US11834380

申请日：2007-08-06

Applicant: Hiroaki SUGA ,  Yigong BU

Inventor： Hiroaki SUGA ,  Yigong BU

IPC: A61K31/44 ,  A61K31/34 ,  A61P43/00 ,  C07C233/00 ,  C07C233/16 ,  C07D217/00 ,  C07D231/00 ,  C07D231/56 ,  C12N1/20 ,  C12Q1/02 ,  C40B40/04 ,  G01N33/566

CPC classification number: C07D285/13 ,  C07C235/74 ,  C07C237/42 ,  C07C2601/08 ,  C07C2601/14 ,  C07D309/10 ,  C07D319/06 ,  Y02P20/582

Abstract: The present invention relates to solid phase or solution phase combinatorial libraries of autoinducer analogs. The present invention also relates to autoinducer agonists and antagonists. In addition, the present invention relates to methods for identifying autoinducer agonists and antagonists, as well as methods for regulating the activity of an autoinducer receptor, regulating biofilm formation, regulating growth or virulence of an organism in a subject, inhibiting the quorum sensing mechanism of an organism, and treating an infection in a subject caused by an organism possessing a quorum sensing mechanism which use the autoinducer analogs of the present invention.

Abstract translation: 本发明涉及自动诱导剂类似物的固相或溶液相组合文库。 本发明还涉及自体诱导剂激动剂和拮抗剂。 此外，本发明还涉及用于鉴定自身诱导剂激动剂和拮抗剂的方法，以及用于调节自身诱导剂受体活性的方法，调节生物膜形成，调节受试者中生物体的生长或毒力，抑制群体感受机制 一种有机体，并且治疗由具有本发明的自动诱导剂类似物的具有群体感应机制的生物体引起的受试者感染。

公开(公告)号：US20120296094A1

公开(公告)日：2012-11-22

申请号：US13567695

申请日：2012-08-06

Applicant: Hiroaki SUGA ,  Jun Igarashi

Inventor： Hiroaki SUGA ,  Jun Igarashi

IPC: C07D207/14 ,  C07D295/32 ,  C07D211/58

CPC classification number: C07D207/50 ,  A01N43/36 ,  A01N43/40 ,  A61K8/4913 ,  A61K8/4926 ,  A61Q11/00 ,  A61Q17/005 ,  C07D207/14 ,  C07D211/58 ,  C07D295/32

Abstract: The present invention provides a new amide compound and salt thereof that is capable of inhibiting biofilm formation or removing deposited biofilms. The present invention also provides a biofilm formation inhibitor or a biofilm remover containing the amide compound or salt thereof as an active ingredient.An amide compound or salt thereof according to the present invention is denoted by General Formula (1): wherein R1 is a hydrogen atom or a hydroxyl group, R2 is a C5-12 alkyl group, and Q is a substituent denoted by Formula (Q1) or (Q2), wherein n and m are 0 or 1.

Abstract translation: 本发明提供了能够抑制生物膜形成或去除沉积的生物膜的新的酰胺化合物及其盐。 本发明还提供了含有酰胺化合物或其盐作为活性成分的生物膜形成抑制剂或生物膜去除剂。 根据本发明的酰胺化合物或其盐由通式（1）表示：其中R1是氢原子或羟基，R2是C5-12烷基，Q是由式（Q1）表示的取代基 ）或（Q2），其中n和m为0或1。

公开(公告)号：US20080241081A1

公开(公告)日：2008-10-02

申请号：US11935554

申请日：2007-11-06

Applicant: Hiroaki SUGA ,  Jun Igarashi

Inventor： Hiroaki SUGA ,  Jun Igarashi

IPC: A61Q11/00 ,  A61K31/164 ,  A61K31/44 ,  A61P31/04 ,  A61P1/02

CPC classification number: A61K8/4913 ,  A61K8/42 ,  A61K8/4926 ,  A61K31/164 ,  A61K31/44 ,  A61Q11/00

Abstract: The present invention provides a biofilm stripping agent for removing biofilms already formed. The biofilm stripping agent of the present invention contains, as an active ingredient, an amide compound or salt thereof denoted by General Formula (1), wherein R is a C1-11 alkyl group, and Q is a substituent denoted by the following Formulas (Q1), (Q2) or (Q3), wherein, in Formula (Q1), n is an integer ranging from 0 to 4; in Formula (Q2), R1 is a C1-4 alkyl group, and R2 is a hydroxyl group or carbamoyl group; in Formula (Q3), R3 is a hydrogen atom, hydroxyl group or carbamoyl group.

Abstract translation: 本发明提供了用于去除已经形成的生物膜的生物膜剥离剂。 本发明的生物膜剥离剂含有由通式（1）表示的酰胺化合物或其盐，其中R为C 1-11烷基，Q为 由下式（Q1），（Q2）或（Q3）表示的取代基，其中，在式（Q1）中，n为0〜4的整数。 在式（Q2）中，R 1是C 1-4烷基，R 2是羟基或氨基甲酰基; 在式（Q3）中，R 3是氢原子，羟基或氨基甲酰基。