公开(公告)号：US20050069294A1

公开(公告)日：2005-03-31

申请号：US10939241

申请日：2004-09-10

Applicant: Haruo Tagawa ,  Yoshihiro Hinode ,  Keiichi Fujiwara

Inventor： Haruo Tagawa ,  Yoshihiro Hinode ,  Keiichi Fujiwara

IPC: H04N5/915 ,  H04N5/77 ,  H04N7/18 ,  H04N9/804 ,  H04N5/91

CPC classification number: H04N21/42661 ,  G08B13/19645 ,  G08B13/19667 ,  G08B13/19693 ,  H04N5/23241 ,  H04N5/77 ,  H04N7/18 ,  H04N9/8042 ,  H04N21/2187 ,  H04N21/4223 ,  H04N21/4432

Abstract: It is an object to provide a monitoring image recording apparatus capable of carrying out multi-screen monitoring through a live image by means of a plurality of cameras even if an auxiliary power switch is turned OFF. There are provided an image data compressing and extending portion 104 for compressing and extending monitoring image data, an HDD 107 for recording the image data thus compressed, and a control portion 130 for controlling the image data compressing and extending portion 104 and the HDD 107, the control portion 130 has an HDD power supply control portion 200 for controlling the supply of a power to the HDD 107.

Abstract translation: 本发明的目的是提供一种监视图像记录装置，即使辅助电源开关被关闭，也能通过多个摄像机通过实时图像进行多屏监视。 提供了用于压缩和扩展监视图像数据的图像数据压缩和扩展部分104，用于记录如此压缩的图像数据的HDD 107和用于控制图像数据压缩和扩展部分104和HDD 107的控制部分130， 控制部分130具有用于控制向HDD 107供电的HDD电源控制部分200。

公开(公告)号：US20110053942A1

公开(公告)日：2011-03-03

申请号：US12867532

申请日：2009-02-13

Applicant: Keiichi Fujiwara ,  Yasushi Ochiai ,  Yohei Kimura

Inventor： Keiichi Fujiwara ,  Yasushi Ochiai ,  Yohei Kimura

IPC: A61K31/5375 ,  A61K31/519 ,  A61K31/167 ,  A61K31/417 ,  A61K31/423

CPC classification number: A61K31/5375 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059

Abstract: The present invention relates to an orally disintegrating tablet containing (1) an active ingredient, (2) mannitol, (3) crystalline cellulose and (4) at least two kinds of particular ingredients selected from the group consisting of low-substituted hydroxypropylcellulose, cornstarch and carmellose, wherein the blending ratio of each ingredient relative to 100 wt % of the disintegrating tablet is (1) 0.01 to 50 wt %, (2) 20 to 86 wt %, (3) 10 to 30 wt %, and (4) 1 to 20 wt % for each particular ingredient and 3 to 60 wt % as the total of the particular ingredients to be blended, and an assembly of (3) crystalline cellulose to be blended has a bulk density of not more than 0.18 g/cm3, and can provide an orally disintegrating tablet having both suitable hardness and rapid disintegrability in oral cavity, which maintains orally disintegrability even under moist conditions, and hardness of not less than a predetermined level necessary for using in an automatic packaging machine.

Abstract translation: 本发明涉及一种口腔崩解片，其含有（1）活性成分，（2）甘露醇，（3）结晶纤维素和（4）至少两种选自低取代羟丙基纤维素，玉米淀粉 和羧甲基纤维素，其中各成分相对于崩解片100重量％的配合比例为（1）0.01〜50重量％，（2）20〜86重量％，（3）10〜30重量％，（4） ）对于每种特定成分为1至20重量％，并且将要混合的特定成分的总量为3至60重量％，并且（3）待混合的结晶纤维素的组合体积密度不超过0.18克/ 并且可以提供口腔崩解片，其在口腔中具有合适的硬度和快速崩解性，即使在潮湿条件下也保持口腔崩解性，并且在自动包装机中使用不低于预定水平的硬度。

公开(公告)号：US08153161B2

公开(公告)日：2012-04-10

申请号：US10582174

申请日：2004-12-07

Applicant: Keiichi Fujiwara ,  Kiyomi Sogo ,  Shizuo Okamoto ,  Koichiro Shibamori ,  Norihito Shimono

Inventor： Keiichi Fujiwara ,  Kiyomi Sogo ,  Shizuo Okamoto ,  Koichiro Shibamori ,  Norihito Shimono

IPC: A61K9/50 ,  A61K9/20

CPC classification number: A61K9/1652 ,  A61K9/0056 ,  A61K9/1623 ,  A61K9/2077 ,  A61K31/5375 ,  A61K47/26 ,  A61K47/38

Abstract: The invention provides a medicament-containing particle wherein an unpleasant taste of the medicament is alleviated, which is obtainable by mixing and granulating the following ingredients: (1) the medicament with an unpleasant taste, (2) methylcellulose and (3) mannitol; and a solid preparation including the particle. The invention can make an unpleasant taste of the medicament alleviated and furthermore when the formulation including the particle is administered, the unpleasant taste can be masked and the formulation has a good dissolvability in gastrointestinal tract.

Abstract translation: 本发明提供了一种药物含有颗粒，其中药物的令人不快的味道得到缓解，其可通过混合和造粒以下成分获得：（1）具有不愉快味道的药物，（2）甲基纤维素和（3）甘露醇; 和包含该颗粒的固体制剂。 本发明可以使缓解的药物变得令人不愉快的味道，此外，当施用包含颗粒的制剂时，可以掩蔽不愉快的味道，并且制剂在胃肠道中具有良好的溶解性。

公开(公告)号：US20070148230A1

公开(公告)日：2007-06-28

申请号：US10582174

申请日：2004-12-07

Applicant: Keiichi Fujiwara ,  Kiyomi Sogo ,  Shizuo Okamoto ,  Koichiro Shibamori ,  Norihito Shimono

Inventor： Keiichi Fujiwara ,  Kiyomi Sogo ,  Shizuo Okamoto ,  Koichiro Shibamori ,  Norihito Shimono

IPC: A61K31/5375 ,  A61K9/20

CPC classification number: A61K9/1652 ,  A61K9/0056 ,  A61K9/1623 ,  A61K9/2077 ,  A61K31/5375 ,  A61K47/26 ,  A61K47/38

Abstract: The invention provides a medicament-containing particle wherein an unpleasant taste of the medicament is alleviated, which is obtainable by mixing and granulating the following ingredients: (1) the medicament with an unpleasant taste, (2) methylcellulose and (3) mannitol; and a solid preparation including the particle. The invention can make an unpleasant taste of the medicament alleviated and furthermore when the formulation including the particle is administered, the unpleasant taste can be masked and the formulation has a good dissolvability in gastrointestinal tract.

Abstract translation: 本发明提供了一种药物含有颗粒，其中药物的令人不快的味道得到缓解，其可通过混合和造粒以下成分获得：（1）具有不愉快味道的药物，（2）甲基纤维素和（3）甘露醇; 和包含该颗粒的固体制剂。 本发明可以使缓解的药物变得令人不愉快的味道，此外，当施用包含颗粒的制剂时，可以掩蔽不愉快的味道，并且制剂在胃肠道中具有良好的溶解性。

公开(公告)号：US08900602B2

公开(公告)日：2014-12-02

申请号：US13389874

申请日：2010-08-11

Applicant: Keiichi Fujiwara ,  Tadashi Fukami ,  Haruka Koizumi

Inventor： Keiichi Fujiwara ,  Tadashi Fukami ,  Haruka Koizumi

IPC: A23L1/48 ,  A61K47/26 ,  A61K9/20 ,  A61K31/5375 ,  A61K9/00

CPC classification number: A61K9/0056 ,  A61K9/2018 ,  A61K31/5375

Abstract: Disclosed is an orally rapidly disintegrating tablet which has a good texture and taste in the oral cavity, such a sufficient hardness as not giving any worry of being chipped or dusted during production or transportation and good disintegrating properties in the oral cavity. The orally rapidly disintegrating tablet, which has a good texture and taste, an appropriate hardness, and good disintegrating properties, can be produced by using a composition, which is prepared by dispersing, by spray-drying, an inorganic excipient and starch(es) in complex particles composed of mannitol and xylitol, in an orally rapidly disintegrating tablet.

Abstract translation: 公开了一种在口腔中具有良好质地和口感的口腔快速崩解片，足够的硬度，不会在生产或运输过程中担心切屑或粉尘，并且在口腔中具有良好的崩解性能。 可以通过使用通过喷雾干燥分散无机赋形剂和淀粉而制备的组合物来制备具有良好的质地和味道，适当的硬度和良好的崩解性的口腔快速崩解片剂， 在由甘露糖醇和木糖醇组成的复合颗粒中，在口腔快速崩解片剂中。

公开(公告)号：US08591955B2

公开(公告)日：2013-11-26

申请号：US13389280

申请日：2010-08-11

Applicant: Keiichi Fujiwara

Inventor： Keiichi Fujiwara

IPC: A61K9/50

CPC classification number: A61K31/5375 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/5089

Abstract: The present invention provides an orally rapidly-disintegrating tablet comprising at least two particles. Regarding medicaments with unpleasant taste, the present invention provides a tablet comprising such medicament having a suitable hardness so that the tablet can be handled without any difficulty in the period from the formulation of the tablet to the administration thereof (in particular, a tablet which can maintain the hardness thereof when it is stored under a humidified condition); a small size; no unpleasant taste; a pleasant feeling in a mouth after administration; and an excellent disintegration character in the oral cavity and an excellent dissolution character in the gastrointestinal tract.

Abstract translation: 本发明提供一种包含至少两种颗粒的口服快速崩解片剂。 对于具有不愉快味道的药物，本发明提供了包含具有适当硬度的药物的片剂，使得片剂可以在从片剂的制剂到给药期间无任何困难地处理（特别是可以将片剂 保持其在加湿条件下储存时的硬度）; 小尺寸 没有不愉快的味道; 给药后口感愉快; 在口腔中具有优异的崩解性，并且在胃肠道中具有极好的溶解特性。

公开(公告)号：US20120165413A1

公开(公告)日：2012-06-28

申请号：US13389874

申请日：2010-08-11

Applicant: Keiichi Fujiwara ,  Tadashi Fukami ,  Haruka Koizumi

Inventor： Keiichi Fujiwara ,  Tadashi Fukami ,  Haruka Koizumi

IPC: A61K47/26 ,  A23L1/48

CPC classification number: A61K9/0056 ,  A61K9/2018 ,  A61K31/5375

Abstract: Disclosed is an orally rapidly disintegrating tablet which has a good texture and taste in the oral cavity, such a sufficient hardness as not giving any worry of being chipped or dusted during production or transportation and good disintegrating properties in the oral cavity. The orally rapidly disintegrating tablet, which has a good texture and taste, an appropriate hardness, and good disintegrating properties, can be produced by using a composition, which is prepared by dispersing, by spray-drying, an inorganic excipient and starch(es) in complex particles composed of mannitol and xylitol, in an orally rapidly disintegrating tablet.

Abstract translation: 公开了一种在口腔中具有良好质地和口感的口腔快速崩解片，足够的硬度，不会在生产或运输过程中担心切屑或粉尘，并且在口腔中具有良好的崩解性能。 可以通过使用通过喷雾干燥分散无机赋形剂和淀粉而制备的组合物来制备具有良好的质地和味道，适当的硬度和良好的崩解性的口腔快速崩解片剂， 在由甘露糖醇和木糖醇组成的复合颗粒中，在口腔快速崩解片剂中。

公开(公告)号：US09446055B2

公开(公告)日：2016-09-20

申请号：US13389880

申请日：2010-08-11

Applicant: Keiichi Fujiwara ,  Tadashi Fukami ,  Haruka Koizumi

Inventor： Keiichi Fujiwara ,  Tadashi Fukami ,  Haruka Koizumi

IPC: A61K47/26 ,  A61K31/167 ,  A61K9/14 ,  A61K31/616 ,  A61K9/00 ,  A61K9/20

CPC classification number: A61K31/616 ,  A61K9/0056 ,  A61K9/2018

Abstract: There has been a need for an orally rapidly disintegrating tablet which has a good texture and taste in the oral cavity, such a sufficient hardness as not giving any worry of being chipped or dusted during production or transportation and good disintegrating properties in the oral cavity and can sustain a sufficient hardness even under humid conditions after opening. Disclosed are a disintegrating particle composition which is prepared by dispersing, in the presence of water, mannitol, xylitol, an inorganic excipient, a disintegrating agent and carmellose and drying, and an orally rapidly disintegrating tablet which comprises said disintegrating particle composition, an active substance and a disintegrating agent. The disintegrating tablet has a good texture and taste, an appropriate hardness and good disintegrating properties and can sustain a sufficient hardness under humid conditions.

Abstract translation: 需要一种在口腔中具有良好质地和口感的口服快速崩解片剂，足够的硬度，不会在生产或运输过程中担心不会被切碎或撒粉，并且在口腔中具有良好的崩解性能， 即使在开放后的潮湿条件下，也能维持足够的硬度。 公开了通过在水，甘露糖醇，木糖醇，无机赋形剂，崩解剂和羧甲基纤维素和干燥剂的存在下分散而制备的崩解颗粒组合物，以及包含所述崩解颗粒组合物的口服快速崩解片剂，活性物质 和崩解剂。 崩解片具有良好的质地和味道，适当的硬度和良好的崩解性能，并能在潮湿条件下维持足够的硬度。

公开(公告)号：US20120156261A1

公开(公告)日：2012-06-21

申请号：US13389880

申请日：2010-08-11

Applicant: Keiichi Fujiwara ,  Tadashi Fukami ,  Haruka Koizumi

Inventor： Keiichi Fujiwara ,  Tadashi Fukami ,  Haruka Koizumi

IPC: A61K47/26 ,  A61K31/167 ,  A61K9/14 ,  A61K31/616 ,  A61K47/02 ,  A61K47/34

CPC classification number: A61K31/616 ,  A61K9/0056 ,  A61K9/2018

Abstract: There has been a need for an orally rapidly disintegrating tablet which has a good texture and taste in the oral cavity, such a sufficient hardness as not giving any worry of being chipped or dusted during production or transportation and good disintegrating properties in the oral cavity and can sustain a sufficient hardness even under humid conditions after opening. Disclosed are a disintegrating particle composition which is prepared by dispersing, in the presence of water, mannitol, xylitol, an inorganic excipient, a disintegrating agent and carmellose and drying, and an orally rapidly disintegrating tablet which comprises said disintegrating particle composition, an active substance and a disintegrating agent. The disintegrating tablet has a good texture and taste, an appropriate hardness and good disintegrating properties and can sustain a sufficient hardness under humid conditions.

Abstract translation: 需要一种在口腔中具有良好的质地和口感的口服快速崩解片剂，足够的硬度，不会在生产或运输过程中担心不会被切碎或撒粉，并且在口腔中具有良好的崩解性能， 即使在开放后的潮湿条件下，也能维持足够的硬度。 公开了通过在水，甘露醇，木糖醇，无机赋形剂，崩解剂和羧甲基纤维素和干燥剂的存在下分散而制备的崩解颗粒组合物，以及包含所述崩解颗粒组合物的口服快速崩解片剂，活性物质 和崩解剂。 崩解片具有良好的质地和味道，适当的硬度和良好的崩解性能，并能在潮湿条件下维持足够的硬度。

公开(公告)号：US20120135991A1

公开(公告)日：2012-05-31

申请号：US13389280

申请日：2010-08-11

Applicant: Keiichi Fujiwara

Inventor： Keiichi Fujiwara

IPC: A61K47/38 ,  A61P1/00 ,  A61K31/5375

CPC classification number: A61K31/5375 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/5089

Abstract: The present invention provides an orally rapidly-disintegrating tablet comprising at least two particles. Regarding medicaments with unpleasant taste, the present invention provides a tablet comprising such medicament having a suitable hardness so that the tablet can be handled without any difficulty in the period from the formulation of the tablet to the administration thereof (in particular, a tablet which can maintain the hardness thereof when it is stored under a humidified condition); a small size; no unpleasant taste; a pleasant feeling in a mouth after administration; and an excellent disintegration character in the oral cavity and an excellent dissolution character in the gastrointestinal tract.

Abstract translation: 本发明提供一种包含至少两种颗粒的口服快速崩解片剂。 对于具有不愉快味道的药物，本发明提供了包含具有适当硬度的药物的片剂，使得片剂可以在从片剂的制剂到给药期间无任何困难地处理（特别是可以将片剂 保持其在加湿条件下储存时的硬度）; 小尺寸 没有不愉快的味道; 给药后口感愉快; 在口腔中具有优异的崩解性，并且在胃肠道中具有极好的溶解特性。