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公开(公告)号:US08551955B2
公开(公告)日:2013-10-08
申请号:US12914840
申请日:2010-10-28
申请人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
发明人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
CPC分类号: A61K38/08 , A61K38/00 , A61K38/06 , A61K38/191 , C07D207/16 , C07D401/14 , C07D403/14 , C07D413/14 , C07K5/06026 , C07K5/0806 , C07K7/02 , C07K14/4747 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译: 本发明提供Smac肽的小分子模拟物,其是具有通过连接体连接的两个结合结构域的二聚体或二聚体样化合物。 这些化合物可用于促进凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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公开(公告)号:US20110195043A1
公开(公告)日:2011-08-11
申请号:US12914840
申请日:2010-10-28
申请人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
发明人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
CPC分类号: A61K38/08 , A61K38/00 , A61K38/06 , A61K38/191 , C07D207/16 , C07D401/14 , C07D403/14 , C07D413/14 , C07K5/06026 , C07K5/0806 , C07K7/02 , C07K14/4747 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译: 本发明提供了Smac肽的小分子模拟物,其是具有通过连接物连接的两个结合结构域的二聚体或二聚体样化合物。这些化合物可用于促进细胞凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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公开(公告)号:US20130344026A1
公开(公告)日:2013-12-26
申请号:US13973979
申请日:2013-08-22
申请人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
发明人: Haizhou Sun , Xiaoming Xu , Ming Zhou , Susan Harran , Gunnar James Hanson , Lai Wang
CPC分类号: A61K38/08 , A61K38/00 , A61K38/06 , A61K38/191 , C07D207/16 , C07D401/14 , C07D403/14 , C07D413/14 , C07K5/06026 , C07K5/0806 , C07K7/02 , C07K14/4747 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要: The invention provides small molecule mimics of the Smac peptide that are dimers or dimer-like compounds having two binding domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译: 本发明提供Smac肽的小分子模拟物,其是具有通过连接体连接的两个结合结构域的二聚体或二聚体样化合物。 这些化合物可用于促进凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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公开(公告)号:US08642554B2
公开(公告)日:2014-02-04
申请号:US12101733
申请日:2008-04-11
申请人: Gunnar Hanson , Haizhou Sun
发明人: Gunnar Hanson , Haizhou Sun
CPC分类号: A61K38/06 , A61K38/05 , A61K45/06 , C07D207/16 , C07D403/14 , C07D409/14 , C07K5/06 , C07K5/08
摘要: The invention provides small molecule mimics of the Smac peptide that are dimer-like or trimer-like compounds having two or three amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
摘要翻译: 本发明提供Smac肽的小分子模拟物,其是具有通过连接体连接的具有两个或三个含酰胺的结构域的二聚体样或三聚体样化合物。 这些化合物可用于促进凋亡。 本发明包括包含这些化合物的药物组合物和使用它们来治疗包括癌症和自身免疫疾病的病症的方法。
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