公开(公告)号：US06515539B1

公开(公告)日：2003-02-04

申请号：US09548012

申请日：2000-04-12

申请人： Haim Levanon ,  Aharon Blank

发明人： Haim Levanon ,  Aharon Blank

IPC分类号： H01S100

CPC分类号： H01S1/02

摘要： Optically pumped masers are described. The devices are useful for microwave amplification, microwave phase shifting and microwave limiting function. The devices are based on electron spin polarization of a stable free radical species induced by an intermolecular energy transfer process acting via a photo induced radical-triplet pair mechanism. A paramagnetic triplet precursor chromophore in a matrix with the stable free radical species is irradiated, preferably using a pulsed laser to initiate the process with concomitant increase in matrix magnetic susceptibility. Microwave radiation incident on the photo activated matrix is reflected as amplified, phase shifted or limited microwave fields dependent on relevant device parameters and on the power of the incident microwave radiation.

摘要翻译： 描述了光学泵送器。 该器件适用于微波放大，微波相移和微波限制功能。 这些器件基于通过经由光诱导的自由基 - 三线态对机制作用的分子间能量转移过程诱导的稳定的自由基物质的电子自旋极化。 照射具有稳定自由基物质的基质中的顺磁性三线态前体发色团，优选使用脉冲激光来引发该方法，伴随着基质磁化率的增加。 入射到光激活矩阵上的微波辐射被反射为放大，相移或有限的微波场，取决于相关器件参数和入射微波辐射的功率。

公开(公告)号：US20100308820A1

公开(公告)日：2010-12-09

申请号：US12675801

申请日：2008-08-27

申请人： Aharon Blank ,  Itai Katz

发明人： Aharon Blank ,  Itai Katz

IPC分类号： G01R33/48

CPC分类号： G01R33/3808 ,  G01N24/08 ,  G01R33/383 ,  G01R33/46

摘要： A device for ex situ magnetic resonance analysis is disclosed. The device comprises a static magnetic field unit (12) for generating a generally cylindrically symmetric static magnetic field outside the static magnetic field unit, and a radiofrequency unit (14) for generating a generally cylindrically symmetric radiofrequency field outside the radiofrequency unit. The radiofrequency field is perpendicular to the static magnetic field. A spatial inhomogeneity of the magnetic field substantially matches a spatial inhomogeneity of the radiofrequency field.

摘要翻译： 公开了一种用于非原位磁共振分析的装置。 该装置包括用于在静磁场单元外部产生大致圆柱形对称的静态磁场的静态磁场单元（12），以及用于在射频单元外部产生大致圆柱对称的射频场的射频单元（14）。 射频场垂直于静磁场。 磁场的空间不均匀性与射频场的空间不均匀性基本一致。

公开(公告)号：US07403008B2

公开(公告)日：2008-07-22

申请号：US11195388

申请日：2005-08-02

申请人： Aharon Blank ,  Curt R. Dunnam ,  Peter P. Borbat ,  Jack H. Freed

发明人： Aharon Blank ,  Curt R. Dunnam ,  Peter P. Borbat ,  Jack H. Freed

IPC分类号： G01V3/00

CPC分类号： G01R33/60

摘要： ESR microscope systems and methods for examining specimens using both continuous wave and pulsed modes in the 9 to 60 GHz range. The ESR microscope uses an image probe comprising gradient coils in addition to conventional modulation coils (in continuous wave mode) or magnetic field bias coils (in pulse mode), and a resonator constructed from high permittivity material. The systems and methods also involves the use of sample containers that permit the precise placement of samples in relation to the image probe. The microscope uses a microstrip or thin coaxial or dielectric antenna to obtain a high coupling coefficient to the specimen being imaged. The microscope systems provide resolution at the single micron level, and permit the observation of images comprising tens to hundreds of pixels for each of two or three dimensions in a few minutes. Novel stable radicals used as the imaging media are also described.

摘要翻译： ESR显微镜系统和在9至60 GHz范围内使用连续波和脉冲模式检查样本的方法。 除常规调制线圈（连续波模式）或磁场偏置线圈（脉冲模式）外，ESR显微镜还使用包含梯度线圈的图像探头，以及由高介电常数材料构成的谐振器。 这些系统和方法还涉及使用允许相对于图像探针精确放置样品的样品容器。 显微镜使用微带或薄的同轴或电介质天线来获得与成像样本的高耦合系数。 显微镜系统提供单一微米级别的分辨率，并且允许在几分钟内观察包括数十到数百个像素的图像，每个二维或三维的图像。 还描述了用作成像介质的新型稳定自由基。

公开(公告)号：US20060084866A1

公开(公告)日：2006-04-20

申请号：US10968828

申请日：2004-10-18

申请人： Gadi Lewkonya ,  Yuval Zur ,  Hanna Friedman ,  Aharon Blank

发明人： Gadi Lewkonya ,  Yuval Zur ,  Hanna Friedman ,  Aharon Blank

IPC分类号： A61B6/00

CPC分类号： A61B5/055 ,  A61B5/02007 ,  A61B5/6862 ,  A61B5/6876 ,  G01R33/285

摘要： An imaging probe for imaging inside a cavity surrounded by a wall, the probe comprising: a) a probe body having a contracted state and an expanded state; and b) at least two imaging sensors, mounted on the probe body and having fields of view in different directions; wherein, when the probe body is in the expanded state, the fields of view of the imaging sensors respectively comprise portions of the wall of the cavity on different sides of the cavity.

摘要翻译： 一种成像探针，用于在由围墙围绕的空腔内成像，所述探针包括：a）具有收缩状态和膨胀状态的探针体; 以及b）至少两个成像传感器，安装在探针主体上并具有不同方向的视野; 其中，当所述探针体处于展开状态时，所述成像传感器的视场分别包括所述空腔的不同侧上的所述腔的壁的部分。

公开(公告)号：US08461836B2

公开(公告)日：2013-06-11

申请号：US12675801

申请日：2008-08-27

申请人： Aharon Blank ,  Itai Katz

发明人： Aharon Blank ,  Itai Katz

IPC分类号： G01V3/00

CPC分类号： G01R33/3808 ,  G01N24/08 ,  G01R33/383 ,  G01R33/46

摘要： A device for ex situ magnetic resonance analysis is disclosed. The device comprises a static magnetic field unit (12) for generating a generally cylindrically symmetric static magnetic field outside the static magnetic field unit, and a radiofrequency unit (14) for generating a generally cylindrically symmetric radiofrequency field outside the radiofrequency unit. The radiofrequency field is perpendicular to the static magnetic field. A spatial inhomogeneity of the magnetic field substantially matches a spatial inhomogeneity of the radiofrequency field.

摘要翻译： 公开了一种用于非原位磁共振分析的装置。 该装置包括用于在静磁场单元外部产生大致圆柱形对称的静态磁场的静态磁场单元（12），以及用于在射频单元外部产生大致圆柱对称的射频场的射频单元（14）。 射频场垂直于静磁场。 磁场的空间不均匀性与射频场的空间不均匀性基本一致。

公开(公告)号：US20120025828A1

公开(公告)日：2012-02-02

申请号：US13263852

申请日：2010-04-15

申请人： Aharon Blank ,  Ygal Twig

发明人： Aharon Blank ,  Ygal Twig

IPC分类号： G01R33/60

CPC分类号： G01N24/10 ,  A61B5/055 ,  A61B5/4504 ,  A61B5/4547 ,  G01R33/3808 ,  G01R33/383 ,  G01R33/3873 ,  G01R33/60

摘要： A device of estimating a dose of ionizing radiation absorbed in an intra bone volume. The device comprises a static magnetic field source adapted to generate a substantially static magnetic field in a probing space having a volume of less than 2 cubic millimeter (mm3), the probing space being placed in front of a distal end of static magnetic field source, a micro resonator mounted in adjacent to the distal end, and at least one transmission line which feeds the resonator so as to generate an microwave magnetic field at the probing space and to transmit a signal returned from said microwave magnetic field and indicative of radiation induced paramagnetic defects in said probing space so as to allow a spectrometer to compute a dose of ionizing radiation absorbed in a portion of a bone placed in the probing space according to an analysis of the signal. The static magnetic field source being sized and shaped to maneuver the probing space to overlap with an intra bone volume of the bone.

摘要翻译： 估计吸收在骨内体积中的电离辐射剂量的装置。 该装置包括适于在具有小于2立方毫米（mm 3）的体积的探测空间中产生基本上静态的磁场的静态磁场源，探测空间被放置在静态磁场源的远端的前方， 安装在远端附近的微型谐振器和至少一个传输线，其馈送谐振器，以便在探测空间产生微波磁场并传输从所述微波磁场返回的信号，并指示辐射诱导的顺磁性 所述探测空间中的缺陷，以便允许光谱仪根据信号的分析来计算放置在探测空间中的骨的一部分中吸收的电离辐射的剂量。 静态磁场源的尺寸和形状适于调节探测空间以与骨的骨内体积重叠。

公开(公告)号：US09194922B2

公开(公告)日：2015-11-24

申请号：US13275504

申请日：2011-10-18

申请人： Aharon Blank ,  Ygal Twig

发明人： Aharon Blank ,  Ygal Twig

IPC分类号： G01R33/28 ,  G01R33/60 ,  G01R33/341 ,  G01R33/34

CPC分类号： G01R33/341 ,  G01R33/34007 ,  G01R33/60

摘要： A resonator system for electron spin resonance (ESR) is disclosed. The resonator system comprises: a generally planar resonator layer defining an open-loop gapped by a non-conductive gap in the layer, and a microwave feed, positioned configured for transmitting microwave to the resonator layer such as to concentrate, with a quality factor of at least 100, a magnetic field within an effective volume of less than 1 nL above the layer.

摘要翻译： 公开了一种用于电子自旋共振（ESR）的谐振器系统。 谐振器系统包括：大致平面的谐振器层，其限定由该层中的非导电间隙进行开环的开环;以及微波馈入，定位成将微波传输到谐振器层，以便将谐波层发射到集中，质量因子 至少100个，在层之上小于1nL的有效体积内的磁场。

公开(公告)号：US08766634B2

公开(公告)日：2014-07-01

申请号：US13263852

申请日：2010-04-15

申请人： Aharon Blank ,  Ygal Twig

发明人： Aharon Blank ,  Ygal Twig

IPC分类号： G01V3/00

CPC分类号： G01N24/10 ,  A61B5/055 ,  A61B5/4504 ,  A61B5/4547 ,  G01R33/3808 ,  G01R33/383 ,  G01R33/3873 ,  G01R33/60

摘要： A device of estimating a dose of ionizing radiation absorbed in an intra bone volume. The device comprises a static magnetic field source adapted to generate a substantially static magnetic field in a probing space having a volume of less than 2 cubic millimeter (mm3), the probing space being placed in front of a distal end of static magnetic field source, a micro resonator mounted in adjacent to the distal end, and at least one transmission line which feeds the resonator so as to generate an microwave magnetic field at the probing space and to transmit a signal returned from said microwave magnetic field and indicative of radiation induced paramagnetic defects in said probing space so as to allow a spectrometer to compute a dose of ionizing radiation absorbed in a portion of a bone placed in the probing space according to an analysis of the signal. The static magnetic field source being sized and shaped to maneuver the probing space to overlap with an intra bone volume of the bone.

摘要翻译： 估计吸收在骨内体积中的电离辐射剂量的装置。 该装置包括适于在具有小于2立方毫米（mm 3）的体积的探测空间中产生基本上静态的磁场的静态磁场源，探测空间被放置在静态磁场源的远端的前方， 安装在远端附近的微型谐振器和至少一个传输线，其馈送谐振器，以便在探测空间产生微波磁场并传输从所述微波磁场返回的信号，并指示辐射诱导的顺磁性 所述探测空间中的缺陷，以便允许光谱仪根据信号的分析来计算放置在探测空间中的骨的一部分中吸收的电离辐射的剂量。 静态磁场源的尺寸和形状适于调节探测空间以与骨的骨内体积重叠。

公开(公告)号：US20100001728A1

公开(公告)日：2010-01-07

申请号：US12304770

申请日：2007-06-14

申请人： Aharon Blank ,  Lazar Shtirberg

发明人： Aharon Blank ,  Lazar Shtirberg

IPC分类号： G01R33/48 ,  G01R33/44

CPC分类号： G01R33/60 ,  G01N24/10 ,  G01R33/3808 ,  G01R33/385

摘要： ESR imaging probe, system, and method are described. The probe is an ex-situ probe, the system comprises the probe and configured for operating the probe, and the method comprises detecting ESR from outside a resonator of the probe. An exemplary embodiment of a probe according to the invention comprises a cooled dielectric resonator, and one sided gradient coils. An exemplary embodiment of the system comprises source current that is configured to supply to the gradient coils currents of up to 100 A in pulses shorter than 1 μsec.

摘要翻译： 描述了ESR成像探针，系统和方法。 该探针是一个非原位探针，该系统包括探针并配置用于操作该探针，该方法包括从探头的谐振器外部检测ESR。 根据本发明的探针的示例性实施例包括冷却介质谐振器和单侧梯度线圈。 系统的示例性实施例包括源电流，其被配置为以比1个音箱短的脉冲向梯度线圈提供高达100A的电流。

公开(公告)号：US06704594B1

公开(公告)日：2004-03-09

申请号：US09705732

申请日：2000-11-06

申请人： Aharon Blank ,  Gil Alexandrowicz ,  Erez Golan

发明人： Aharon Blank ,  Gil Alexandrowicz ,  Erez Golan

IPC分类号： A61B505

CPC分类号： G01R33/3808

摘要： An imaging probe and method and an MRI system utilizing the same are presented. The probe comprises first and second magnetic field sources, and a receiver of NMR signals. The first magnetic field source creates a primary, substantially non-homogeneous, static magnetic field in a region of interest in a medium outside the probe. The second magnetic field source creates an external time-varying magnetic field, which when being applied to the region of the static magnetic field, is capable of exciting nuclei in an extended sub-region of this region and generating the NMR signals.

摘要翻译： 提出了一种成像探针和方法以及利用其的MRI系统。 探头包括第一和第二磁场源以及NMR信号的接收器。 第一磁场源在探针外部的介质中在感兴趣的区域中产生初级的，基本上非均匀的静态磁场。 第二磁场源产生外部时变磁场，当被施加到静态磁场的区域时，能够激发该区域的扩展子区域中的核并产生NMR信号。