公开(公告)号：US09310450B2

公开(公告)日：2016-04-12

申请号：US13522353

申请日：2011-01-31

申请人： Erez Golan

发明人： Erez Golan

IPC分类号： G01R33/483 ,  G01R33/30 ,  G01R33/563 ,  G01R33/341 ,  G01R33/3415

CPC分类号： G01R33/483 ,  G01R33/30 ,  G01R33/341 ,  G01R33/3415 ,  G01R33/56375

摘要： A system (10) for margin assessment of an ex-vivo tissue (18), including an imaging scanner (12) controlled by an imaging control unit (14), and an ex-vivo sample holder (16) for holding a sample of an excised tissue (18), the sample holder (16) being sized such that excised lump edges (24) of the excised tissue (18) are forced against a surface of the sample holder (16) such that the edges (24) change shape to have a predetermined geometry, and wherein the imaging scanner (12) is positioned relative to the sample holder (16) such that the imaging scanner (12) acquires images not of all the tissue (18) but rather of the edges (24) that have the predetermined geometry and which are in a sensitive region (40) extending into a peripheral margin of the tissue (18).

摘要翻译： 一种用于离体组织（18）的边缘评估的系统（10），包括由成像控制单元（14）控制的成像扫描仪（12），以及用于保持样品的样品的离体样品保持器（16） 切除的组织（18），样本保持器（16）的尺寸使得切除的组织（18）的切除的块边缘（24）被迫抵靠在样品架（16）的表面上，使得边缘（24）改变 形状具有预定的几何形状，并且其中成像扫描器（12）相对于样品保持器（16）定位，使得成像扫描器（12）获取不是所有组织（18）的图像，而是获取边缘（24） ），其具有预定几何形状并且位于延伸到组织（18）的周边边缘的敏感区域（40）中。

公开(公告)号：US09554816B2

公开(公告)日：2017-01-31

申请号：US13514090

申请日：2010-12-03

申请人： Erez Golan

发明人： Erez Golan

IPC分类号： A61B17/22 ,  A61B17/221

CPC分类号： A61B17/22031 ,  A61B17/22 ,  A61B17/221 ,  A61B2017/22098 ,  A61B2090/064

摘要： A device for fracturing calcifications in heart valves including an expandable stabilizer (14) and expandable impactor arms (20) assembled on and deployed by a delivery system (10), wherein the delivery system (10) is operable to move the impactor arms (20), while in an expanded position, with respect to the stabilizer (14) with sufficient energy so as to fracture a calcification located in tissure which is sandwiched between the stabilizer (14) and the impactor arms (20).

摘要翻译： 一种用于在心脏瓣膜中破裂钙化的装置，包括组装在输送系统（10）上并由输送系统（10）展开的可膨胀稳定器（14）和可膨胀的冲击臂（20），其中输送系统（10）可操作以移动冲击器臂 ），而在膨胀的位置，相对于具有足够能量的稳定器（14），以便分解位于稳定器（14）和冲击臂（20）之间的组织中的钙化。

公开(公告)号：US06377048B1

公开(公告)日：2002-04-23

申请号：US09707905

申请日：2000-11-08

申请人： Erez Golan ,  Aharon Blank ,  Gil Alexandrowicz

发明人： Erez Golan ,  Aharon Blank ,  Gil Alexandrowicz

IPC分类号： G01V300

CPC分类号： G01R33/3873

摘要： An MRI system is presented utilizing a magnetic assembly of a kind which, when accommodated within a primary static reasonably homogeneous magnetic field created by the MRI system affects the static magnetic field to cause creation of a region of substantial non-homogeneity of the static magnetic field in the vicinity of the magnetic assembly. By this, a local static field gradient is created. The magnetic assembly comprises a passive magnetic element, which deforms a pattern of the static magnetic field, while not being a magnetic field source by to itself.

摘要翻译： 使用一种磁性组件来呈现MRI系统，其在容纳在由MRI系统产生的主要静态合理均匀的磁场内时会影响静态磁场，从而产生静态磁场的实质上非均匀性的区域 在磁性组件附近。 由此，创建本地静态场渐变。 磁性组件包括一个被动磁性元件，它使静态磁场的图形变形，而不是一个磁场源自身。

公开(公告)号：US06704594B1

公开(公告)日：2004-03-09

申请号：US09705732

申请日：2000-11-06

申请人： Aharon Blank ,  Gil Alexandrowicz ,  Erez Golan

发明人： Aharon Blank ,  Gil Alexandrowicz ,  Erez Golan

IPC分类号： A61B505

CPC分类号： G01R33/3808

摘要： An imaging probe and method and an MRI system utilizing the same are presented. The probe comprises first and second magnetic field sources, and a receiver of NMR signals. The first magnetic field source creates a primary, substantially non-homogeneous, static magnetic field in a region of interest in a medium outside the probe. The second magnetic field source creates an external time-varying magnetic field, which when being applied to the region of the static magnetic field, is capable of exciting nuclei in an extended sub-region of this region and generating the NMR signals.

摘要翻译： 提出了一种成像探针和方法以及利用其的MRI系统。 探头包括第一和第二磁场源以及NMR信号的接收器。 第一磁场源在探针外部的介质中在感兴趣的区域中产生初级的，基本上非均匀的静态磁场。 第二磁场源产生外部时变磁场，当被施加到静态磁场的区域时，能够激发该区域的扩展子区域中的核并产生NMR信号。

公开(公告)号：US09717513B2

公开(公告)日：2017-08-01

申请号：US13055507

申请日：2009-07-27

申请人： Erez Golan

发明人： Erez Golan

IPC分类号： A61B17/22 ,  A61B17/3207 ,  A61B17/00 ,  A61F2/24

CPC分类号： A61B17/22012 ,  A61B17/320725 ,  A61B2017/00243 ,  A61B2017/00535 ,  A61B2017/00783 ,  A61B2017/22051 ,  A61B2017/22061 ,  A61B2017/22069 ,  A61B2017/22097 ,  A61B2017/22098 ,  A61B2017/320716 ,  A61F2/2418 ,  A61F2/2427

摘要： A device for fracturing calcifications in heart valves including a catheter (12, 22, 42) configured for percutaneous delivery to a heart valve, an fracture-producing element (14, 26, 46, 64, 66,82, 124, 152) disposed at a distal portion of the catheter and operative to vibrate and mechanically fracture calcifications when brought into contact with a calcification at a leaflet of the heart valve, and an energy source (34, 47, 79, 98, 152) operative to vibrate the fracture-producing element so that the fracture-producing element fractures the calcification without necessarily removing the calcification from the leaflet. The device may further comprise a valvuloplasty balloon (30), an embolic protection net (56) and a protective sleeve (110, 130).

公开(公告)号：US20120299591A1

公开(公告)日：2012-11-29

申请号：US13522353

申请日：2011-01-31

申请人： Erez Golan

发明人： Erez Golan

IPC分类号： G01R33/30 ,  G01R33/48

CPC分类号： G01R33/483 ,  G01R33/30 ,  G01R33/341 ,  G01R33/3415 ,  G01R33/56375

摘要： A system (10) for margin assessment of an ex-vivo tissue (18), including an imaging scanner (12) controlled by an imaging control unit (14), and an ex-vivo sample holder (16) for holding a sample of an excised tissue (18), the sample holder (16) being sized such that excised lump edges (24) of the excised tissue (18) are forced against a surface of the sample holder (16) such that the edges (24) change shape to have a predetermined geometry, and wherein the imaging scanner (12) is positioned relative to the sample holder (16) such that the imaging scanner (12) acquires images not of all the tissue (18) but rather of the edges (24) that have the predetermined geometry and which are in a sensitive region (40) extending into a peripheral margin of the tissue (18).

摘要翻译： 一种用于离体组织（18）的边缘评估的系统（10），包括由成像控制单元（14）控制的成像扫描仪（12），以及用于保持样品的样品的离体样品保持器（16） 切除的组织（18），样本保持器（16）的尺寸使得切除的组织（18）的切除的块边缘（24）被迫抵靠在样品架（16）的表面上，使得边缘（24）改变 形状具有预定的几何形状，并且其中成像扫描器（12）相对于样品保持器（16）定位，使得成像扫描器（12）获取不是所有组织（18）的图像，而是获取边缘（24） ），其具有预定几何形状并且位于延伸到组织（18）的周边边缘的敏感区域（40）中。

公开(公告)号：US20120253358A1

公开(公告)日：2012-10-04

申请号：US13514090

申请日：2010-12-03

申请人： Erez Golan

发明人： Erez Golan

IPC分类号： A61B17/22

CPC分类号： A61B17/22031 ,  A61B17/22 ,  A61B17/221 ,  A61B2017/22098 ,  A61B2090/064

摘要： A device for fracturing calcifications in heart valves including an expandable stabilizer (14) and expandable impactor arms (20) assembled on and deployed by a delivery system (10), wherein the delivery system (10) is operable to move the impactor arms (20), while in an expanded position, with respect to the stabilizer (14) with sufficient energy so as to fracture a calcification located in tissure which is sandwiched between the stabilizer (14) and the impactor arms (20).

摘要翻译： 一种用于在心脏瓣膜中破裂钙化的装置，包括组装在输送系统（10）上并由输送系统（10）展开的可膨胀稳定器（14）和可膨胀的冲击臂（20），其中输送系统（10）可操作以移动冲击器臂 ），而在膨胀的位置，相对于具有足够能量的稳定器（14），以便分解位于稳定器（14）和冲击臂（20）之间的组织中的钙化。

公开(公告)号：US20110118634A1

公开(公告)日：2011-05-19

申请号：US13055507

申请日：2009-07-27

申请人： Erez Golan

发明人： Erez Golan

IPC分类号： A61B17/22

CPC分类号： A61B17/22012 ,  A61B17/320725 ,  A61B2017/00243 ,  A61B2017/00535 ,  A61B2017/00783 ,  A61B2017/22051 ,  A61B2017/22061 ,  A61B2017/22069 ,  A61B2017/22097 ,  A61B2017/22098 ,  A61B2017/320716 ,  A61F2/2418 ,  A61F2/2427

摘要： A device for fracturing calcifications in heart valves including a catheter (12, 22, 42) configured for percutaneous delivery to a heart valve, an fracture-producing element (14, 26, 46, 64, 66,82, 124, 152) disposed at a distal portion of the catheter and operative to vibrate and mechanically fracture calcifications when brought into contact with a calcification at a leaflet of the heart valve, and an energy source (34, 47, 79, 98, 152) operative to vibrate the fracture-producing element so that the fracture-producing element fractures the calcification without necessarily removing the calcification from the leaflet. The device may further comprise a valvuloplasty balloon (30), an embolic protection net (56) and a protective sleeve (110, 130).

摘要翻译： 一种用于在心脏瓣膜中破裂钙化的装置，包括构造成用于经皮递送至心脏瓣膜的导管（12,22,42），设置在骨膜的元件（14,26,46,64,66,82,124,152） 在所述导管的远端部分处于与所述心脏瓣膜的小叶处的钙化接触时振动并机械破裂钙化的能量源（34,47,79,98,152），所述能源用于使所述骨折振动 使得骨折产生元件破裂钙化，而不必从小叶中除去钙化。 该装置还可包括瓣膜成形术球囊（30），栓塞保护网（56）和保护套管（110,130）。

公开(公告)号：US06600319B2

公开(公告)日：2003-07-29

申请号：US09725887

申请日：2000-11-30

申请人： Erez Golan

发明人： Erez Golan

IPC分类号： G01V300

CPC分类号： G01R33/34053 ,  G01R33/34084 ,  G01V3/32

摘要： A device and method for performing NMR measurements and imaging in a surrounding medium are presented. The method utilizes the detection of magnetic resonance signals from within at least one region of a primary, substantially non-homogeneous, external magnetic field.

摘要翻译： 介绍了一种用于在周围介质中进行NMR测量和成像的装置和方法。 该方法利用从主要的，基本上非均匀的外部磁场的至少一个区域内的磁共振信号的检测。