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公开(公告)号：US11536634B2
公开(公告)日：2022-12-27
申请号：US17133690
申请日：2020-12-24
Applicant: HOLOGIC, INC.
Inventor： Barry F. Hunt , Raymond Jenoski , Ryan Oliva , Michael Cordeiro , Eric Grimes
Abstract: An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, an analytic element positioner having an analytic element holder configured to releasably grip an analytic element, and a specimen transfer device carried by the tool head, wherein the tool head is configured to automatically position a working end of the specimen transfer device to obtain a specimen from a sample container held in the sample container holder, and to transfer the obtained specimen to an analytic element held by the analytic element holder, respectively, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.
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公开(公告)号：US20250123461A1
公开(公告)日：2025-04-17
申请号：US18991276
申请日：2024-12-20
Applicant: Hologic, Inc.
Inventor： Barry F. Hunt , Jeffrey D. Struven , Sidney H. Mayer
IPC: G02B7/36 , G02B21/24 , G02B21/34 , G02B21/36 , H04N23/959
Abstract: A system and method for acquiring images of objects distributed within a specimen affixed to a surface of a slide, the specimen having an uneven height relative to the slide surface using a camera having an objective lens with an optical axis that forms a non-orthogonal angle with the surface of the slide, the method including acquiring a first plurality of images of a first linear portion of the specimen; evaluating a focus of objects within the linear portion of the specimen captured in the first plurality of images; and acquiring a second plurality of images of the first linear portion or of a second linear portion of the specimen different from the first, wherein a height of the objective lens relative to the slide surface is varied during acquisition of the second plurality of images based on the evaluated focus of the objects captured in the first plurality of images.
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公开(公告)号：US12204172B2
公开(公告)日：2025-01-21
申请号：US17749985
申请日：2022-05-20
Applicant: HOLOGIC, INC.
Inventor： Barry F. Hunt , Jeffrey D. Struven , Sidney H. Mayer
IPC: G02B7/36 , G02B21/24 , G02B21/36 , H04N23/959 , G02B21/34
Abstract: A system and method for acquiring images of objects distributed within a specimen affixed to a surface of a slide, the specimen having an uneven height relative to the slide surface using a camera having an objective lens with an optical axis that forms a non-orthogonal angle with the surface of the slide, the method including acquiring a first plurality of images of a first linear portion of the specimen; evaluating a focus of objects within the linear portion of the specimen captured in the first plurality of images; and acquiring a second plurality of images of the first linear portion or of a second linear portion of the specimen different from the first, wherein a height of the objective lens relative to the slide surface is varied during acquisition of the second plurality of images based on the evaluated focus of the objects captured in the first plurality of images.
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公开(公告)号：US10900875B2
公开(公告)日：2021-01-26
申请号：US16084955
申请日：2018-03-09
Applicant: HOLOGIC, INC.
Inventor： Barry F. Hunt , Raymond Jenoski , Ryan Oliva , Michael Cordeiro , Eric Grimes
Abstract: An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, an analytic element positioner having an analytic element holder configured to releasably grip an analytic element, and a specimen transfer device carried by the tool head, wherein the tool head is configured to automatically position a working end of the specimen transfer device to obtain a specimen from a sample container held in the sample container holder, and to transfer the obtained specimen to an analytic element held by the analytic element holder, respectively, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.
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公开(公告)号：US12298212B2
公开(公告)日：2025-05-13
申请号：US18056680
申请日：2022-11-17
Applicant: HOLOGIC, INC.
Inventor： Barry F. Hunt , Raymond Jenoski , Ryan Oliva , Michael Cordeiro , Eric Grimes
Abstract: An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, an analytic element positioner having an analytic element holder configured to releasably grip an analytic element, and a specimen transfer device carried by the tool head, wherein the tool head is configured to automatically position a working end of the specimen transfer device to obtain a specimen from a sample container held in the sample container holder, and to transfer the obtained specimen to an analytic element held by the analytic element holder, respectively, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.
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Patent Agency Ranking
公开(公告)号：US20220276463A1
公开(公告)日：2022-09-01
申请号：US17749985
申请日：2022-05-20
Applicant: HOLOGIC, INC.
Inventor： Barry F. Hunt , Jeffrey D. Struven , Sidney H. Mayer
Abstract: A system and method for acquiring images of objects distributed within a specimen affixed to a surface of a slide, the specimen having an uneven height relative to the slide surface using a camera having an objective lens with an optical axis that forms a non-orthogonal angle with the surface of the slide, the method including acquiring a first plurality of images of a first linear portion of the specimen; evaluating a focus of objects within the linear portion of the specimen captured in the first plurality of images; and acquiring a second plurality of images of the first linear portion or of a second linear portion of the specimen different from the first, wherein a height of the objective lens relative to the slide surface is varied during acquisition of the second plurality of images based on the evaluated focus of the objects captured in the first plurality of images.
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公开(公告)号：US20250138279A1
公开(公告)日：2025-05-01
申请号：US18991269
申请日：2024-12-20
Applicant: Hologic, Inc.
Inventor： Barry F. Hunt , Jeffrey D. Struven , Sidney H. Mayer
IPC: G02B7/36 , G02B21/24 , G02B21/34 , G02B21/36 , H04N23/959
Abstract: A system and method for acquiring images of objects distributed within a specimen affixed to a surface of a slide, the specimen having an uneven height relative to the slide surface using a camera having an objective lens with an optical axis that forms a non-orthogonal angle with the surface of the slide, the method including acquiring a first plurality of images of a first linear portion of the specimen; evaluating a focus of objects within the linear portion of the specimen captured in the first plurality of images; and acquiring a second plurality of images of the first linear portion or of a second linear portion of the specimen different from the first, wherein a height of the objective lens relative to the slide surface is varied during acquisition of the second plurality of images based on the evaluated focus of the objects captured in the first plurality of images.
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公开(公告)号：US20190041302A1
公开(公告)日：2019-02-07
申请号：US16084955
申请日：2018-03-09
Applicant: HOLOGIC, INC.
Inventor： Barry F. Hunt , Raymond Jenoski , Ryan Oliva , Michael Cordeiro , Eric Grimes
Abstract: An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, an analytic element positioner having an analytic element holder configured to releasably grip an analytic element, and a specimen transfer device carried by the tool head, wherein the tool head is configured to automatically position a working end of the specimen transfer device to obtain a specimen from a sample container held in the sample container holder, and to transfer the obtained specimen to an analytic element held by the analytic element holder, respectively, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.
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9.发明申请公开(公告)号：US20190017906A1
公开(公告)日：2019-01-17
申请号：US15652122
申请日：2017-07-17
Applicant: HOLOGIC, INC.
Inventor： Barry F. Hunt
Abstract: Systems and methods for preparing a cytological specimen from a patient sample in a sample container include or employ mechanisms for quickly and accurately adjusting the pressure in a pressure unit during the specimen preparation. The systems include a specimen transfer device configured for being positioned within the sample container, a pressure tank coupled to the specimen transfer device and configured for applying at least one of positive pressure and vacuum pressure through the specimen transfer device, and a temperature adjusting unit coupled to the pressure tank, and configured for incrementally adjusting the pressure in the pressure tank by heating or cooling the tank. The method includes steps of performing a coarse pressure adjustment using a supply valve and/or a bleed valve coupled to the pressure tank, and, after the coarse adjustment, performing a fine pressure adjustment using a temperature adjusting element coupled to the pressure tank.
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公开(公告)号：US20250155337A1
公开(公告)日：2025-05-15
申请号：US19022689
申请日：2025-01-15
Applicant: HOLOGIC, INC.
Inventor： Barry F. Hunt , Raymond Jenoski , Ryan Oliva , Michael Cordeiro , Eric Grimes
Abstract: An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, a pipettor carried by the tool head, the pipettor having a pipette tip engaging member configured to releasably engage pipette tips, and a supplemental container holder configured for holding a supplemental container, the tool head configured to automatically position the pipette tip engaging member into a position in which an engaged pipette tip is inserted into a sample container held in the sample container holder, and into a position in which an engaged pipette tip is inserted into a supplemental container held in the supplemental container holder, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.
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