公开(公告)号：US3631103A

公开(公告)日：1971-12-28

申请号：US3631103D

申请日：1968-09-12

申请人： HOFFMANN LA ROCHE

发明人： REY-BELLET GERALD ,  SPIEGELBERG HANS

IPC分类号： A61K31/00 ,  C07C51/15 ,  C07C51/373 ,  C07C61/39 ,  C07C62/34 ,  C07C62/38 ,  C07C65/34 ,  C07D213/40 ,  C07D295/185 ,  C07D317/72 ,  C07C103/30

CPC分类号： C07D213/40 ,  A61K31/00 ,  C07C51/15 ,  C07C51/373 ,  C07C61/39 ,  C07C62/34 ,  C07C62/38 ,  C07C65/34 ,  C07D295/185 ,  C07D317/72

摘要： DIBENZO(A,D)CYCLOHEPTA(1,4,6)TRIENES BEARING IN THE 5-POSITION, SUBSTITUENTS SUCH AS, FOR EXAMPLE, OXO-OR 3''LOWER ALKOCYALKYLIDENE AN IN THE 10-POSITION, SUBSTITUENTS SUCH AS, FOR EXAMPLE, CARBONYL, THIOCARBONYL OR GUANYL RADICALS, FOR INSTANCE, 5-(3''-LOWER ALKOXYPROPYLIDENE) - DIBENZO(A,D)CYCLOHEPTA(1,4,6)TRIENE 10 - CARBOXYLIC ACID DI-(LOWER ALKYL)AMIDES AND DIBENZO(A,D) CYCLOHEPTA (1,4,6) TRIEN-5-ONE 10 - CARBOXYLIC ACID CYCLIC AMIDES, PREPARED INTER ALIA, FROM 5-(3''-LOWER ALKOXYPROPYLIDENE) - DIBENZO(A,D)CYCLOHEPTA(1,4,6)TRIENE 10CARBOXYLIC ACID, 10 - HALOCARBONYL - 5-(3''LOWER ALKOXYPROPYLIDENE)DIBENZO(A,D)CYCLOHEPTA(1,4,6)TRIENE OR DIBENZO(A,D)CYCLOHEPTA(1,4,6)TRIENS-5 - ONE 10-CARBOXYLIC ACID HALIDE, ARE DESCRIBED. THE END PRODUCTS ARE USEFUL AS ANTIDEPRESSANTS.

公开(公告)号：US3860615A

公开(公告)日：1975-01-14

申请号：US32260073

申请日：1973-01-10

申请人： HOFFMANN LA ROCHE

发明人： REY-BELLET GERALD ,  SPIEGELBERG HANS

IPC分类号： A61K31/00 ,  C07C51/15 ,  C07C51/373 ,  C07C61/39 ,  C07C62/34 ,  C07C62/38 ,  C07C65/34 ,  C07D213/40 ,  C07D295/185 ,  C07D317/72 ,  C07D13/04

CPC分类号： C07D213/40 ,  A61K31/00 ,  C07C51/15 ,  C07C51/373 ,  C07C61/39 ,  C07C62/34 ,  C07C62/38 ,  C07C65/34 ,  C07D295/185 ,  C07D317/72

摘要： Dibenzo(a,d)cyclohepta(1,4,6)trienes bearing in the 5-position, substituents such as, for example, oxo- or 3''-lower alkoxyalkylidene and in the 10-position, substituents such as, for example, carbonyl, thiocarbonyl or guanyl radicals, for instance, 5-(3''-lower alkoxypropylidene)-dibenzo(a,d)cyclohepta (1,4,6)triene 10-carboxylic acid di-(lower alkyl)amides and dibenzo(a,d)cyclohepta(1,4,6)trien-5-one 10-carboxylic acid cyclic amides, prepared, inter alia, from 5-(3''-lower alkoxypropylidene)-dibenzo(a,d)cyclohepta,(1,4,6)triene 10carboxylic acid, 10-halocarbonyl-5-(3''-lower alkoxypropylidene)dibenzo(a,d)cyclohepta(1,4,6)triene or dibenzo(a,d)cyclohepta(1,4,6)trien-5-one 10-carboxylic acid halide, are described. The end products are useful as antidepressants.

摘要翻译： 具有5-位的二苯并[a，d]环庚烷[1,4,6]三烯，取代基例如氧代或3'-低级烷氧基亚烷基和在10位的取代基，例如 ，羰基，硫代羰基或鸟嘌呤基，例如5-（3'-低级烷氧基亚丙基） - 二苯并[a，d]环庚[1,4,6]三烯10-羧酸二 - （低级烷基）酰胺和二苯并[ a，d]环庚并[1,4,6]三烯-5-酮10-羧酸环状酰胺，特别是由5-（3'-低级烷氧基亚丙基） - 二苯并[a，d]环庚烷，[1 ，4,6]三烯10-羧酸，10-卤代羰基-5-（3'-低级烷氧基亚丙基）二苯并[a，d]环庚[1,4,6]三烯或二苯并[a，d]环庚烯[ 4,6]三烯-5-酮10-羧酸卤化物。 最终产品可用作抗抑郁药。