公开(公告)号：US20210096079A1

公开(公告)日：2021-04-01

申请号：US16968330

申请日：2018-04-06

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs ,  Raghuvir N. Sengupta

IPC: G01N21/65 ,  G01N21/64 ,  G01J3/44

Abstract: A luminescence-enhancement system can include a luminescence-enhancement sensor having a substrate and a group of nanofingers with individual nanofingers that can be flexible and include a support end attached to the substrate, a distal tip positioned distally with respect to the substrate, and a middle portion between the support end and the distal tip. A coating of a metal or metal alloy can be applied to the substrate and the distal tip that is conductively continuous. The middle portion can be devoid of the coating or the coating at the middle portion is conductively discontinuous. A liquid ejector can be present and can include a jetting nozzle to eject a liquid droplet having a volume of 2 pL to 10 μL. The group of nanofingers and the jetting nozzle can be positionable relative to one another for the droplet to be deposited on the group of nanofingers.

公开(公告)号：US11280740B2

公开(公告)日：2022-03-22

申请号：US16968330

申请日：2018-04-06

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs ,  Raghuvir N. Sengupta

IPC: G01N21/65 ,  G01J3/44 ,  G01N21/64 ,  G01N21/552 ,  B82Y15/00

Abstract: A luminescence-enhancement system can include a luminescence-enhancement sensor having a substrate and a group of nanofingers with individual nanofingers that can be flexible and include a support end attached to the substrate, a distal tip positioned distally with respect to the substrate, and a middle portion between the support end and the distal tip. A coating of a metal or metal alloy can be applied to the substrate and the distal tip that is conductively continuous. The middle portion can be devoid of the coating or the coating at the middle portion is conductively discontinuous. A liquid ejector can be present and can include a jetting nozzle to eject a liquid droplet having a volume of 2 pL to 10 μL. The group of nanofingers and the jetting nozzle can be positionable relative to one another for the droplet to be deposited on the group of nanofingers.

公开(公告)号：US10983061B2

公开(公告)日：2021-04-20

申请号：US16606429

申请日：2017-10-24

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs ,  Raghuvir N. Sengupta

IPC: B82Y15/00 ,  G01N21/65

Abstract: A surface enhanced luminescence analyte nano pillar stage may include a substrate, an array of closable pillars extending from the substrate and a fluid supply connected to the array of pillars. The fluid supply is to at least partially replenish fluid amongst the pillars of the array that has evaporated to maintain a level of the fluid amongst the pillars of the array below tops of the pillars.

公开(公告)号：US20250033048A1

公开(公告)日：2025-01-30

申请号：US18713121

申请日：2021-12-15

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Raghuvir N. Sengupta ,  Viktor Shkolnikov ,  Steven Barcelo

IPC: B01L3/00

Abstract: An example microfluidic device comprises a plurality of fluid channels, an unblocking actuator, and a fluid ejection device fluidically coupled to the plurality of fluid channels. The plurality of fluid channels include a plurality of dehydrated reagents disposed within the plurality of fluid channels and a plurality of fluid blocking regions including blocking material disposed between the first fluid chamber and the plurality of dehydrated reagents. The unblocking actuator is coupled to the plurality of fluid channels proximal to the plurality of fluid blocking region.

公开(公告)号：US20220026361A1

公开(公告)日：2022-01-27

申请号：US17297427

申请日：2018-12-18

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Fausto D'Apuzzo ,  Steven Barcelo ,  Raghuvir N. Sengupta

IPC: G01N21/64 ,  G01N21/65

Abstract: In an example method, an ordered array of microdots including an analyte printed on a surface of a surface-enhanced substrate of an analysis chip is probed with an excitation beam of electromagnetic radiation. Emitted radiation is detected from a number of microdots of the ordered array of microdots. Calibration data is generated for the analysis chip with respect to the analyte based on a detected shift in the emitted radiation as compared to the excitation beam.

公开(公告)号：US20200256800A1

公开(公告)日：2020-08-13

申请号：US16606429

申请日：2017-10-24

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs ,  Raghuvir N. Sengupta

IPC: G01N21/65 ,  B82Y15/00

Abstract: A surface enhanced luminescence analyte nano pillar stage may include a substrate, an array of closable pillars extending from the substrate and a fluid supply connected to the array of pillars. The fluid supply is to at least partially replenish fluid amongst the pillars of the array that has evaporated to maintain a level of the fluid amongst the pillars of the array below tops of the pillars.

公开(公告)号：US20250027966A1

公开(公告)日：2025-01-23

申请号：US18713157

申请日：2021-12-15

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Raghuvir N. Sengupta ,  Viktor Shkolnikov ,  Steven Barcelo

IPC: G01N35/10

Abstract: In accordance with the present disclosure, an example non-transitory computer readable medium may store instructions that when executed cause a computing device to dispense, using a first fluid ejector of a microfluidic device, a biologic sample to a region of a substrate, dispense, using a second fluid ejector of the microfluidic device, a reagent to the region of the substrate, and dispense, using a third fluid ejector of the microfluidic device, a metabolic indicator to the region of the substrate, wherein the metabolic indicator provides a visual indication in response to reaction with the biologic sample.

公开(公告)号：US11280739B2

公开(公告)日：2022-03-22

申请号：US16077334

申请日：2017-07-17

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Raghuvir N. Sengupta ,  Anita Rogacs

IPC: G01N21/65 ,  B82Y15/00

Abstract: A surface enhanced luminescence system may include a laser and a controller to output control signals causing the laser to irradiate the pre-analyte exposed plasmonic surface while maintaining a profile of the pre-analyte exposed plasmonic surface.

公开(公告)号：US11169091B2

公开(公告)日：2021-11-09

申请号：US16082399

申请日：2017-07-20

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Christopher N. Young ,  Milo Overbay ,  Anita Rogacs ,  Raghuvir N. Sengupta

IPC: G01N1/10 ,  G01N21/552 ,  G01N21/64 ,  G01N21/65

Abstract: A surfaced enhanced luminescence analyte interrogation stage shipping and storage package may include a sealed chamber, a liquid contained within the sealed chamber and nano pillars within the sealed chamber and submersed within the liquid. The nano pillars comprise polymer posts and metallic caps forming tips of the nano pillars.

公开(公告)号：US20210252499A1

公开(公告)日：2021-08-19

申请号：US17054675

申请日：2018-10-11

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Fausto D'Apuzzo ,  Trinny Tat ,  Raghuvir N. Sengupta ,  Steven Barcelo ,  Anita Rogacs

IPC: B01L3/02

Abstract: In one example, an apparatus includes a surface-enhanced substrate having a microdot deposited onto a surface thereon via a microfluidic ejector. The microdot includes a predetermined concentration of an analyte.