公开(公告)号：US11051749B2

公开(公告)日：2021-07-06

申请号：US15570927

申请日：2016-05-02

Applicant: Health Research, Inc. ,  Albany Medical College

Inventor： Gerwin Schalk ,  Anthony L. Ritaccio ,  Adriana De Pesters ,  AmiLyn Taplin

IPC: A61B5/38 ,  A61N1/36 ,  A61N1/32 ,  A61B5/00 ,  A61N1/05 ,  G16H20/70

Abstract: Provided is a method for mapping a neural area involved in speech processing, including applying a plurality of recording electrodes to a surface of a cortex of a human subject, presenting a plurality of auditory stimuli to the subject wherein some of the plurality of stimuli are speech sounds and others of the plurality of auditory stimuli are non-speech sounds, recording brain activity during the presenting of the plurality of auditory stimuli, and identifying one or more brain areas wherein activity changes more after presentation of speech sounds than it does after presentation of non-speech sounds, wherein the human subject does not speak during the presenting and the recording. Also provided is a method for mapping a neural area involved in speech production wherein the human subject does not speak during presenting speech stimuli and recording neural activity.

公开(公告)号：US09138579B2

公开(公告)日：2015-09-22

申请号：US14502295

申请日：2014-09-30

Applicant: HEALTH RESEARCH, INC.

Inventor： Jonathan R. Wolpaw ,  Gerwin Schalk ,  Aiko K. Thompson ,  Peter Brunner ,  Xiang Yang Chen ,  Dennis J. McFarland

IPC: A61N1/00 ,  A61N1/36 ,  A61B5/0488 ,  A61N1/04 ,  A61B5/0492 ,  A61B5/00

CPC classification number: A61N1/36014 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/4848 ,  A61B5/6828 ,  A61B5/742 ,  A61B2562/046 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103

Abstract: The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.

Abstract translation: 本发明提供了用于恢复或改善受试者的神经系统功能的方法，装置和系统。 提供了一种方法，其包括：（i）提供有效地在受试者的主要靶向中枢神经系统（CNS）途径中产生靶向神经可塑性（TNP）的操作调节方案; 和（ii）向受试者施用操作调节方案以在主要靶向CNS途径中引发TNP，并在一个或多个其它CNS途径中引发广义神经可塑性（GNP）。 在一种或多种其他CNS途径中引发GNP用于恢复或改善受试者的神经系统功能。 提供了包括神经刺激 - 肌电记录部件和根据操作调节方案来操作神经刺激 - 肌电图记录部件的控制器的装置。

公开(公告)号：US11779256B2

公开(公告)日：2023-10-10

申请号：US17365032

申请日：2021-07-01

Applicant: Health Research, Inc. ,  Albany Medical College

Inventor： Gerwin Schalk ,  Anthony L. Ritaccio ,  Adriana De Pesters ,  AmiLyn Taplin

IPC: A61B5/38 ,  A61N1/36 ,  A61N1/32 ,  A61B5/03 ,  A61B5/00 ,  A61N1/05 ,  G16H20/70

CPC classification number: A61B5/03 ,  A61B5/4064 ,  A61B5/4094 ,  A61N1/0531 ,  A61N1/32 ,  A61N1/36082 ,  A61B2505/05 ,  G16H20/70

Abstract: Provided is a method for mapping a neural area involved in speech processing, including applying a plurality of recording electrodes to a surface of a cortex of a human subject, presenting a plurality of auditory stimuli to the subject wherein some of the plurality of stimuli are speech sounds and others of the plurality of auditory stimuli are non-speech sounds, recording brain activity during the presenting of the plurality of auditory stimuli, and identifying one or more brain areas wherein activity changes more after presentation of speech sounds than it does after presentation of non-speech sounds, wherein the human subject does not speak during the presenting and the recording. Also provided is a method for mapping a neural area involved in speech production wherein the human subject does not speak during presenting speech stimuli and recording neural activity.

公开(公告)号：US10478086B2

公开(公告)日：2019-11-19

申请号：US15558780

申请日：2016-03-17

Applicant: HEALTH RESEARCH, INC.

Inventor： Gerwin Schalk ,  Peter Brunner ,  William G. Coon ,  Adriana De Pesters

IPC: A61B5/0484 ,  A61N1/36 ,  A61B5/04 ,  A61B5/0478 ,  A61B5/00

Abstract: The present invention includes a responsive neural stimulator having electrodes, a filter, a processor, a recording medium, an extractor for extracting instantaneous voltage amplitudes of biased oscillatory activity with asymmetrically distributed peak/trough amplitudes, and a neural stimulator connected to the processor configured to apply neural stimulation via the neural stimulator when a predetermined state of neuronal excitability is detected, a state of relatively higher neuronal excitability corresponding to a relatively lower instantaneous voltage amplitude extracted by the extractor. Also provided is a system for providing neurofeedback including electrodes, a filter, a processor, a recording medium, an extractor for extracting instantaneous voltage amplitudes of biased oscillatory activity with asymmetrically distributed peak/trough amplitudes, and an output device configured to communicate changes in, increases in, decreases in, or maintenance of instantaneous voltage amplitudes, or any combination, to a participant in a neurofeedback session.

公开(公告)号：US09545515B2

公开(公告)日：2017-01-17

申请号：US14855879

申请日：2015-09-16

Applicant: Health Research, Inc.

Inventor： Jonathan R. Wolpaw ,  Gerwin Schalk ,  Aiko K. Thompson ,  Peter Brunner ,  Xiang Yang Chen ,  Dennis J. McFarland

IPC: A61N1/00 ,  A61N1/36 ,  A61B5/0488 ,  A61N1/04 ,  A61B5/0492 ,  A61B5/00

CPC classification number: A61N1/36014 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/4848 ,  A61B5/6828 ,  A61B5/742 ,  A61B2562/046 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103

Abstract: The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.

Abstract translation: 本发明提供了用于恢复或改善受试者的神经系统功能的方法，装置和系统。 提供了一种方法，其包括：（i）提供有效地在受试者的主要靶向中枢神经系统（CNS）途径中产生靶向神经可塑性（TNP）的操作调节方案; 和（ii）向受试者施用操作调节方案以在主要靶向CNS途径中引发TNP，并在一个或多个其它CNS途径中引发广义神经可塑性（GNP）。 在一种或多种其他CNS途径中引发GNP用于恢复或改善受试者的神经系统功能。 提供了包括神经刺激 - 肌电记录部件和根据操作调节方案来操作神经刺激 - 肌电图记录部件的控制器的装置。

公开(公告)号：US08862236B2

公开(公告)日：2014-10-14

申请号：US13958181

申请日：2013-08-02

Applicant: Health Research, Inc.

Inventor： Jonathan R. Wolpaw ,  Gerwin Schalk ,  Aiko K. Thompson ,  Peter Brunner ,  Xiang Yang Chen ,  Dennis J. McFarland

IPC: A61N1/00 ,  A61N1/36

CPC classification number: A61N1/36014 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/4848 ,  A61B5/6828 ,  A61B5/742 ,  A61B2562/046 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/36103

Abstract: The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.

Abstract translation: 本发明提供了用于恢复或改善受试者的神经系统功能的方法，装置和系统。 提供了一种方法，其包括：（i）提供有效地在受试者的主要靶向中枢神经系统（CNS）途径中产生靶向神经可塑性（TNP）的操作调节方案; 和（ii）向受试者施用操作调节方案以在主要靶向CNS途径中引发TNP，并在一个或多个其它CNS途径中引发广义神经可塑性（GNP）。 在一种或多种其他CNS途径中引发GNP用于恢复或改善受试者的神经系统功能。 提供了包括神经刺激 - 肌电记录部件和根据操作调节方案来操作神经刺激 - 肌电图记录部件的控制器的装置。