公开(公告)号：US09688612B2

公开(公告)日：2017-06-27

申请号：US14651857

申请日：2013-12-17

Applicant: HAMARI CHEMICALS, LTD.

Inventor： Hiroki Moriwaki ,  Ryosuke Takeda ,  Akie Kawamura ,  Aki Kawashima ,  Vadim A. Soloshonok

IPC: C07D223/14 ,  C07D223/18 ,  C07C227/30 ,  C07C319/12 ,  C07D209/20 ,  C07B53/00 ,  C07C227/32 ,  C07C229/08 ,  C07C229/36 ,  C07F15/04

CPC classification number: C07C227/30 ,  C07B53/00 ,  C07C227/32 ,  C07C229/08 ,  C07C229/36 ,  C07C319/12 ,  C07D209/20 ,  C07D223/14 ,  C07F15/045

Abstract: An object of the present invention is to provide a method for producing an optically active amino acid in high yield and in a highly enantioselective manner, which method has fewer restrictions on the material that can be used as the substrate, and to provide, among others, a compound useful as a chiral auxiliary for the method. The present invention provides an N-(2-acylaryl)-2-[5,7-dihydro-6H-dibenzo[c,e]azepin-6-yl]acetamide compound represented by Formula (1): or a salt thereof, or a metal complex represented, by Formula (3):

公开(公告)号：US20200024305A1

公开(公告)日：2020-01-23

申请号：US16496245

申请日：2018-03-29

Applicant: Hamari Chemicals, Ltd.

Inventor： Fumitoshi Sumino ,  Ayaka Deguchi ,  Rui Ono ,  Yuta Hiroyama ,  Teruhiko Kanno ,  Hiroki Moriwaki

IPC: C07K1/04 ,  C07K1/34 ,  B01F7/32 ,  B01F15/06

Abstract: An object of the present invention is to provide a novel solid phase peptide synthesis method for synthesizing a large amount of a peptide. Another object of the present invention is to provide a novel solid phase peptide synthesis method for synthesizing a high-purity long-chain peptide. Still another object of the present invention is to provide a novel solid phase peptide synthesis method causing fewer side reactions. The present invention relates to a method for producing a peptide, and the method comprises solid-phase synthesis of a peptide under stirring with a centrifugal stirrer having no impeller.

公开(公告)号：US20160102045A1

公开(公告)日：2016-04-14

申请号：US14890887

申请日：2014-03-27

Applicant: HAMARI CHEMICALS, LTD.

Inventor： Hiroki Moriwaki ,  Aki Kawashima ,  Ryosuke Takeda ,  Akie Kawamura ,  Vadim A. Soloshonok

IPC: C07C227/32 ,  C07B53/00 ,  C07C231/18 ,  C07F15/04 ,  C07D213/55

CPC classification number: C07C227/32 ,  C07B53/00 ,  C07B2200/07 ,  C07C231/18 ,  C07C319/20 ,  C07C2601/02 ,  C07D213/55 ,  C07D223/14 ,  C07F15/045 ,  C07C229/22 ,  C07C229/24 ,  C07C229/30 ,  C07C229/36 ,  C07C229/48 ,  C07C237/08 ,  C07C323/58

Abstract: Objects of the present invention are to provide an industrially applicable method for producing an optically active α-amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active α,α-disubstituted α-amino acid, and to provide an intermediate useful for the above production methods of an optically active α-amino acid and an optically active α,α-disubstituted α-amino acid.The present invention provides a production method of an optically active α-amino acid or a salt thereof, the production method comprising introducing a substituent into the α carbon in the α-amino acid moiety of a metal complex represented by the following Formula (1): by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure α-amino acid enantiomer or a salt thereof by acid decomposition of the metal complex.

Abstract translation: 本发明的目的是提供以高产率和高度对映选择性的方式制备光学活性α-氨基酸的工业上可行的方法，以提供光学活性α，α-二取代α-氨基酸的简单制备方法 并且提供可用于上述光学活性α-氨基酸和光学活性α，α-二取代α-氨基酸的制备方法的中间体。 本发明提供光学活性α-氨基酸或其盐的制造方法，其特征在于，在下述式（1）表示的金属络合物的α-氨基酸部分的α碳中引入取代基， ：通过烷基化反应，醛醇缩合反应，迈克尔反应或曼尼期反应，并通过金属络合物的酸分解释放光学纯的α-氨基酸对映异构体或其盐。

公开(公告)号：US11084846B2

公开(公告)日：2021-08-10

申请号：US16496245

申请日：2018-03-29

Applicant: Hamari Chemicals, Ltd.

Inventor： Fumitoshi Sumino ,  Ayaka Deguchi ,  Rui Ono ,  Yuta Hiroyama ,  Teruhiko Kanno ,  Hiroki Moriwaki

IPC: C07K1/04 ,  B01J8/10 ,  B01F7/32 ,  B01F15/06 ,  C07K1/34 ,  B01J19/00

Abstract: An object of the present invention is to provide a novel solid phase peptide synthesis method for synthesizing a large amount of a peptide. Another object of the present invention is to provide a novel solid phase peptide synthesis method for synthesizing a high-purity long-chain peptide. Still another object of the present invention is to provide a novel solid phase peptide synthesis method causing fewer side reactions. The present invention relates to a method for producing a peptide, and the method comprises solid-phase synthesis of a peptide under stirring with a centrifugal stirrer having no impeller.

公开(公告)号：US09695112B2

公开(公告)日：2017-07-04

申请号：US14890887

申请日：2014-03-27

Applicant: HAMARI CHEMICALS, LTD.

Inventor： Hiroki Moriwaki ,  Aki Kawashima ,  Ryosuke Takeda ,  Akie Kawamura ,  Vadim A. Soloshonok

IPC: C07D213/55 ,  C07C227/32 ,  C07D223/14 ,  C07B53/00 ,  C07C319/20 ,  C07C231/18 ,  C07F15/04

CPC classification number: C07C227/32 ,  C07B53/00 ,  C07B2200/07 ,  C07C231/18 ,  C07C319/20 ,  C07C2601/02 ,  C07D213/55 ,  C07D223/14 ,  C07F15/045 ,  C07C229/22 ,  C07C229/24 ,  C07C229/30 ,  C07C229/36 ,  C07C229/48 ,  C07C237/08 ,  C07C323/58

Abstract: Objects of the present invention are to provide an industrially applicable method for producing an optically active α-amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active α,α-disubstituted α-amino acid, and to provide an intermediate useful for the above production methods of an optically active α-amino acid and an optically active α,α-disubstituted α-amino acid.The present invention provides a production method of an optically active α-amino acid or a salt thereof, the production method comprising introducing a substituent into the α carbon in the α-amino acid moiety of a metal complex represented by the following Formula (1): by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure α-amino acid enantiomer or a salt thereof by acid decomposition of the metal complex.