公开(公告)号：US20210302368A1

公开(公告)日：2021-09-30

申请号：US17259016

申请日：2019-06-19

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Yu HASHIMOTO ,  Sayaka KAZAMI

IPC: G01N27/447

Abstract: The support body includes a concentrating portion, which concentrates the object, between the first end portion and the second end portion. When an area of a cut section of the flow path when cut at a predetermined position in the first direction along a plane orthogonal to the first direction is a flow path cross-sectional area, a flow path cross-sectional area of the concentrating portion is smaller than a flow path cross-sectional area in a first region closer to a first end portion side than the concentrating portion, and a flow path cross-sectional area of a second region closer to the second end portion side than the concentrating portion is larger than the flow path cross-sectional area of the concentrating portion.

公开(公告)号：US20240184103A1

公开(公告)日：2024-06-06

申请号：US18285967

申请日：2022-01-13

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Masashi FUKUHARA ,  Yu HASHIMOTO ,  Kazuya SUZUKI ,  Tomoko HYODO

IPC: G02B27/00 ,  G06N20/00

CPC classification number: G02B27/0012 ,  G02B27/0025 ,  G06N20/00

Abstract: A control device includes: an acquisition unit that acquires, for an intensity image obtained by observing an action caused by light corrected using a spatial light modulator based on a Zernike coefficient, an intensity distribution that is a distribution of intensities in a plurality of regions of interest within a predetermined range on the intensity image; a generation unit that calculates a comparison result between the intensity distribution and a target distribution to generate comparison data; and a prediction unit that predicts a Zernike coefficient, which is for performing aberration correction related to the light so that the intensity distribution approaches the target distribution, by inputting the comparison data and the Zernike coefficient, which is a basis of the intensity distribution, to a learning model.

公开(公告)号：US20240185125A1

公开(公告)日：2024-06-06

申请号：US18285954

申请日：2022-01-13

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Masashi FUKUHARA ,  Yu HASHIMOTO ,  Kazuya SUZUKI ,  Tomoko HYODO

IPC: G06N20/00

CPC classification number: G06N20/00

Abstract: A control device includes: an acquisition unit that acquires an intensity distribution along a predetermined direction for an intensity image obtained by observing an action caused by light corrected using a spatial light modulator based on a Zernike coefficient; a generation unit that calculates a comparison result between the intensity distribution and a target distribution to generate comparison data; and a prediction unit that predicts a Zernike coefficient, which is for performing aberration correction related to the light so that the intensity distribution approaches the target distribution, by inputting the comparison data and the Zernike coefficient, which is a basis of the intensity distribution, to a learning model.

公开(公告)号：US20200178858A1

公开(公告)日：2020-06-11

申请号：US16338550

申请日：2017-09-19

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Tomoya NAKAZAWA ,  Rui SEKINE ,  Masato KITABAYASHI ,  Anna IENAKA ,  Yu HASHIMOTO

IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/00

Abstract: A blood glucose measurement device, a blood glucose calculation method, and a blood glucose calculation program capable of accurately measuring a blood glucose level by using light are provided. The blood glucose measurement device includes a light source 11 that outputs measurement light L1 to be input to a living body 50; a light detector 12 that detects the measurement light L1 propagated inside the living body 50 and generates a detection signal in accordance with an intensity of the measurement light L1; and a computation unit that obtains a time lag between a temporal change in a first parameter related to an oxygenated hemoglobin concentration and a temporal change in a second parameter related to a deoxygenated hemoglobin concentration based on the detection signal, and obtains the data related to the blood glucose level based on the time lag.

公开(公告)号：US20240423537A1

公开(公告)日：2024-12-26

申请号：US18705020

申请日：2022-08-10

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Tomoya NAKAZAWA ,  Rui SEKINE ,  Masato KITABYASHI ,  Yu HASHIMOTO ,  Anna IENAKA

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455

Abstract: A metabolism measurement apparatus includes, a photodetector that detects measurement light propagating through the living body and generates a detection signal according to an intensity of the measurement light, and a calculator. The calculator calculates a first parameter and a second parameter based on the detection signal. Each of the first parameter and the second parameter is a temporal relative change amount depending on a concentration of each of O2Hb and HHb in blood and a volume of a blood vessel in an optical path. The calculator obtains, based on the first parameter and the second parameter, a numerical value regarding a concentration of HHb in blood from which an influence of the volume of the blood vessel in the optical path is excluded. The calculator obtains data regarding a degree of metabolism based on the numerical value.

公开(公告)号：US20220155297A1

公开(公告)日：2022-05-19

申请号：US17423133

申请日：2019-11-06

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Yuji KIMURA ,  Sayaka KAZAMI ,  Yu HASHIMOTO ,  Hiroyasu ITOH

IPC: G01N33/566 ,  G01N33/533 ,  G01N21/78 ,  C12M1/40

Abstract: A method for selecting cells highly responsive to a target substance according to the present invention comprises step of: (1a) bringing a sample containing a target substance into contact with a plurality of cells, wherein the cells are cells having a receptor for the target substance and a fluorescent indicator, and the fluorescent indicator emits fluorescence as a result of binding between the target substance and the receptor; (1b) calculating a fluorescence intensity increase rate for each of the cells; and (1c) selecting arbitrary cells exhibiting a fluorescence intensity increase rate within the top 50% among the plurality of cells. According to the present invention, it is possible to detect the target substance in the sample with high sensitivity.