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公开(公告)号：US20230213432A1
公开(公告)日：2023-07-06
申请号：US18008490
申请日：2021-05-26
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Osamu YASUHIKO , Hidenao YAMADA
IPC: G01N15/14
CPC classification number: G01N15/1429 , G01N15/1436 , G01N2015/1006
Abstract: An observation apparatus includes a light source unit, an irradiation optical system, an imaging optical system, a modulation unit, an imaging unit, an analysis unit, beam splitters and, and mirrors. The analysis unit obtains a real part of a function χ(t)=log [1+Uobj(t)/Uref(t)], defined by time series data Uobj(t) of a complex amplitude image of object light on an imaging plane and time series data Uref(t) of a complex amplitude image of reference light on the imaging plane, based on time series data I(t) of an intensity image of interference light on the imaging plane and time series data Iref(t) of an intensity image of the reference light on the imaging plane. Further, the analysis unit obtains an imaginary part of χ(t) from the real part of χ(t) using the Kramers-Kronig relations, and further obtains Uobj(t).
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公开(公告)号：US20250003873A1
公开(公告)日：2025-01-02
申请号：US18703745
申请日：2022-09-29
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Osamu YASUHIKO , Kozo TAKEUCHI , Hidenao YAMADA
Abstract: An observation apparatus includes a light source, a mirror, a condenser lens, an objective lens, a beam splitter, an imaging unit, and an analysis unit. The analysis unit includes an interference intensity image acquisition unit, a first complex amplitude image generation unit, a second complex amplitude image generation unit, a two-dimensional phase image generation unit, a three-dimensional phase image generation unit, a refractive index distribution calculation unit, and a third complex amplitude image generation unit. The analysis unit irradiates an observation object with light along each of a plurality of light irradiation directions by changing an orientation of a reflection surface of the mirror, acquires an interference intensity image for each of the plurality of light irradiation directions from the imaging unit, and performs necessary processing based on the interference intensity images to obtain a three-dimensional refractive index distribution of the observation object.
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公开(公告)号：US20250052678A1
公开(公告)日：2025-02-13
申请号：US18713756
申请日：2022-07-06
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Kozo TAKEUCHI , Osamu YASUHIKO , Hidenao YAMADA
IPC: G01N21/41
Abstract: A refractive index distribution evaluation method, evaluation device, and information processing program, comprising: a data acquisition step or a data acquisition unit for acquiring refractive index distribution data for an object of observation; a selection step or a selection unit for selecting whether a target included in the refractive index distribution data is an evaluation target; and an evaluation step or an evaluation unit for evaluating the refractive index distribution of the evaluation target.
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公开(公告)号：US20220067332A1
公开(公告)日：2022-03-03
申请号：US17445773
申请日：2021-08-24
Applicant: Hamamatsu Photonics k.k.
Inventor： Kibo OTE , Fumio HASHIMOTO , Osamu YASUHIKO , Hidenao YAMADA
Abstract: The method includes an acquisition step for model generation of acquiring a hologram for model generation in which an image of a cell is captured and which is used to generate a learning model, a generation step for model generation of generating a new hologram for model generation having a different focal position from the acquired hologram for model generation and increasing the number of holograms for model generation, and a learning model generation step of generating a learning model by performing machine learning using the increased holograms for model generation.
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公开(公告)号：US20250123201A1
公开(公告)日：2025-04-17
申请号：US18703751
申请日：2022-09-29
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Osamu YASUHIKO , Kozo TAKEUCHI , Hidenao YAMADA
Abstract: An observation apparatus includes a light source, a mirror, a condenser lens, an objective lens, a beam splitter, an imaging unit, and an analysis unit. The analysis unit includes an interference intensity image acquisition unit, a first complex amplitude image generation unit, a second complex amplitude image generation unit, a phase conjugate operation unit, a two-dimensional phase image generation unit, a three-dimensional phase image generation unit, and a refractive index distribution calculation unit. The analysis unit irradiates an observation object with light along each of a plurality of light irradiation directions by changing an orientation of a reflection surface of the mirror, acquires an interference intensity image at a reference position for each of the plurality of light irradiation directions from the imaging unit, and performs necessary processing based on the interference intensity images to obtain a three-dimensional phase image of the observation object.
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Patent Agency Ranking
6.发明公开公开(公告)号：US20230252606A1
公开(公告)日：2023-08-10
申请号：US18009054
申请日：2021-05-24
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Osamu YASUHIKO , Kozo TAKEUCHI
IPC: G06T5/00
CPC classification number: G06T5/002 , G06T2207/10056
Abstract: In a noise estimation step, a noise image included in a target image including linear noises extending along a first direction is estimated. In this case, an evaluation function including a first term representing a difference between a result obtained by performing differentiation processing in a second direction and low frequency component extraction processing in the first direction on the target image and a result obtained by performing differentiation processing in the second direction and low frequency component extraction processing in the first direction on the noise image is used to obtain the noise image which minimizes a value of the evaluation function. In a noise reduction step, a noise reduced image is generated from the target image based on the target image and the noise image.
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公开(公告)号：US20230152206A1
公开(公告)日：2023-05-18
申请号：US17917044
申请日：2021-03-03
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Osamu YASUHIKO , Kozo TAKEUCHI
CPC classification number: G01N15/1434 , G02B21/06 , G02B21/361 , G01N2015/1497 , G01N2015/1006
Abstract: An observation apparatus includes a light source, a lens, a polarizer, a first prism, a condenser lens, an objective lens, a second prism, a ¼ wave plate, a lens, a polarization camera, and an analysis unit. Each of the first prism and the second prism is, for example, a Wollaston prism or a Nomarski prism. The ¼ wave plate inputs light output from the second prism, and outputs two circularly polarized light beams having different rotation directions. The polarization camera inputs two light beams being circularly polarized in different rotation directions by the ¼ wave plate, and acquires an interference image on an imaging plane for each of three or more polarization components.
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公开(公告)号：US20240410825A1
公开(公告)日：2024-12-12
申请号：US18704137
申请日：2022-09-29
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Osamu YASUHIKO , Kozo TAKEUCHI , Hidenao YAMADA
Abstract: An observation apparatus includes a light source, a beam splitter, a mirror, a mirror, a cylindrical lens, a lens, a cylindrical lens, a beam splitter, a lens, a frequency shifter, an imaging unit, and an analysis unit. The analysis unit generates a complex amplitude image of each of a plurality of light irradiation directions of object light based on time series data of an interference intensity image output from the imaging unit, and generates a three-dimensional complex differential interference image of an observation object based on the complex amplitude image of each of the plurality of light irradiation directions. The analysis unit obtains a three-dimensional phase image of the observation object based on the three-dimensional complex differential interference image.
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公开(公告)号：US20230324296A1
公开(公告)日：2023-10-12
申请号：US18024996
申请日：2021-01-21
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Osamu YASUHIKO , Kozo TAKEUCHI , Hidenao YAMADA
CPC classification number: G01N21/45 , G01N21/8851 , G01N21/4795 , G01N2021/1787
Abstract: An observation apparatus includes a light source, a mirror, a condenser lens, an objective lens, a beam splitter, an imaging unit, and an analysis unit. The analysis unit includes an interference intensity image acquisition unit, a first complex amplitude image generation unit, a second complex amplitude image generation unit, a two-dimensional phase image generation unit, a three-dimensional phase image generation unit, and a refractive index distribution calculation unit. The analysis unit irradiates an observation object with light along each of a plurality of light irradiation directions, acquires an interference intensity image at a reference position for each of the plurality of light irradiation directions from the imaging unit, and performs necessary processing based on the interference intensity images to obtain a three-dimensional refractive index distribution of the observation object.
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公开(公告)号：US20200080833A1
公开(公告)日：2020-03-12
申请号：US16561059
申请日：2019-09-05
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Toyohiko YAMAUCHI , Osamu YASUHIKO , Hidenao YAMADA , Hisayuki MATSUI
Abstract: A measurement apparatus includes an interference image acquisition unit, a fluorescence image acquisition unit, an operation unit, and a timing control circuit. The operation unit generates an optical thickness image based on an interference image acquired by the interference image acquisition unit, generates a mask image showing a region in which pixel values in a fluorescence image acquired by the fluorescence image acquisition unit are larger than a threshold value, and determines an integrated value of an optical thickness in the region shown by the mask image in the optical thickness image.
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