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公开(公告)号：US20250123201A1
公开(公告)日：2025-04-17
申请号：US18703751
申请日：2022-09-29
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Osamu YASUHIKO , Kozo TAKEUCHI , Hidenao YAMADA
Abstract: An observation apparatus includes a light source, a mirror, a condenser lens, an objective lens, a beam splitter, an imaging unit, and an analysis unit. The analysis unit includes an interference intensity image acquisition unit, a first complex amplitude image generation unit, a second complex amplitude image generation unit, a phase conjugate operation unit, a two-dimensional phase image generation unit, a three-dimensional phase image generation unit, and a refractive index distribution calculation unit. The analysis unit irradiates an observation object with light along each of a plurality of light irradiation directions by changing an orientation of a reflection surface of the mirror, acquires an interference intensity image at a reference position for each of the plurality of light irradiation directions from the imaging unit, and performs necessary processing based on the interference intensity images to obtain a three-dimensional phase image of the observation object.
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公开(公告)号：US20200333250A1
公开(公告)日：2020-10-22
申请号：US16959241
申请日：2018-10-30
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Toyohiko YAMAUCHI , Hidenao YAMADA
Abstract: A fluorescence measurement apparatus includes a fluorescence image acquisition unit that acquires a fluorescence image containing an object, an interference image acquisition unit that acquires an interference image containing the object, and an operation unit. The operation unit determines an optical thickness image based on the interference image acquired by the interference image acquisition unit, and determines, in a region of interest set in common in both of the fluorescence image acquired by the fluorescence image acquisition unit and the optical thickness image, a fluorescence expression rate of the object based on an integrated value of a fluorescence intensity in the fluorescence image and an integrated value of an optical thickness in the optical thickness image.
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公开(公告)号：US20200263972A1
公开(公告)日：2020-08-20
申请号：US16061499
申请日：2016-12-07
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Toyohiko YAMAUCHI , Hidenao YAMADA
Abstract: An interference observation apparatus includes a light source, a splitting beam splitter, a combining beam splitter, a mirror, a beam splitter, a mirror, a piezo element, a stage, a photodetector, an image acquisition unit, and a current control unit. An interference optical system from the splitting beam splitter to the combining beam splitter forms a Mach-Zehnder interferometer. The current control unit controls a wavelength of laser light output from the light source to adjust a phase difference between two split light components at the combining by the combining beam splitter.
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公开(公告)号：US20250003873A1
公开(公告)日：2025-01-02
申请号：US18703745
申请日：2022-09-29
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Osamu YASUHIKO , Kozo TAKEUCHI , Hidenao YAMADA
Abstract: An observation apparatus includes a light source, a mirror, a condenser lens, an objective lens, a beam splitter, an imaging unit, and an analysis unit. The analysis unit includes an interference intensity image acquisition unit, a first complex amplitude image generation unit, a second complex amplitude image generation unit, a two-dimensional phase image generation unit, a three-dimensional phase image generation unit, a refractive index distribution calculation unit, and a third complex amplitude image generation unit. The analysis unit irradiates an observation object with light along each of a plurality of light irradiation directions by changing an orientation of a reflection surface of the mirror, acquires an interference intensity image for each of the plurality of light irradiation directions from the imaging unit, and performs necessary processing based on the interference intensity images to obtain a three-dimensional refractive index distribution of the observation object.
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公开(公告)号：US20220120660A1
公开(公告)日：2022-04-21
申请号：US17310813
申请日：2020-02-14
Applicant: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE , HAMAMATSU PHOTONICS K.K.
Inventor： Hirotoshi KIKUCHI , Hidenao YAMADA , Amane HIROTSU , Daisuke YAMASHITA , Shigetoshi OKAZAKI
Abstract: A cell observation system observes a cell moving in a flow path with a fluid, and includes a first imaging apparatus, a second imaging apparatus, and a control device. The first imaging apparatus includes a first optical system and a first imaging element, and captures an image of the cell at a first position in a moving direction. The second imaging apparatus includes a second optical system, in which a focus is adjusted based on a focus adjustment signal, and a second imaging element, and captures an image of the cell at a second position downstream of the first position. The control device obtains a passing position of the cell in a cross section of the flow path based on the image obtained by the first imaging element, generates the focus adjustment signal, and provides the signal to the second optical system.
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Patent Agency Ranking
公开(公告)号：US20190072477A1
公开(公告)日：2019-03-07
申请号：US16084307
申请日：2017-03-02
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Hidenao YAMADA , Toyohiko YAMAUCHI
IPC: G01N15/14
Abstract: An observation apparatus observes an observation object moving in a flow path with a fluid, and includes a light source, a splitting unit, a combining unit, a collimator, a cylindrical lens, an objective lens, a collimator, a cylindrical lens, an objective lens, a modulation unit, an imaging unit, an analysis unit, and the like. The imaging unit includes a plurality of pixels arranged in a direction intersecting with a moving direction of an image of the observation object on a light receiving plane on which the image of the observation object moving in the flow path is formed, and receives combined light output from the combining unit to repeatedly output a detection signal indicating a one-dimensional interference image. The analysis unit generates a two-dimensional image of the observation object on the basis of the detection signal.
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公开(公告)号：US20240410825A1
公开(公告)日：2024-12-12
申请号：US18704137
申请日：2022-09-29
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Osamu YASUHIKO , Kozo TAKEUCHI , Hidenao YAMADA
Abstract: An observation apparatus includes a light source, a beam splitter, a mirror, a mirror, a cylindrical lens, a lens, a cylindrical lens, a beam splitter, a lens, a frequency shifter, an imaging unit, and an analysis unit. The analysis unit generates a complex amplitude image of each of a plurality of light irradiation directions of object light based on time series data of an interference intensity image output from the imaging unit, and generates a three-dimensional complex differential interference image of an observation object based on the complex amplitude image of each of the plurality of light irradiation directions. The analysis unit obtains a three-dimensional phase image of the observation object based on the three-dimensional complex differential interference image.
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公开(公告)号：US20230324296A1
公开(公告)日：2023-10-12
申请号：US18024996
申请日：2021-01-21
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Osamu YASUHIKO , Kozo TAKEUCHI , Hidenao YAMADA
CPC classification number: G01N21/45 , G01N21/8851 , G01N21/4795 , G01N2021/1787
Abstract: An observation apparatus includes a light source, a mirror, a condenser lens, an objective lens, a beam splitter, an imaging unit, and an analysis unit. The analysis unit includes an interference intensity image acquisition unit, a first complex amplitude image generation unit, a second complex amplitude image generation unit, a two-dimensional phase image generation unit, a three-dimensional phase image generation unit, and a refractive index distribution calculation unit. The analysis unit irradiates an observation object with light along each of a plurality of light irradiation directions, acquires an interference intensity image at a reference position for each of the plurality of light irradiation directions from the imaging unit, and performs necessary processing based on the interference intensity images to obtain a three-dimensional refractive index distribution of the observation object.
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公开(公告)号：US20200080833A1
公开(公告)日：2020-03-12
申请号：US16561059
申请日：2019-09-05
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Toyohiko YAMAUCHI , Osamu YASUHIKO , Hidenao YAMADA , Hisayuki MATSUI
Abstract: A measurement apparatus includes an interference image acquisition unit, a fluorescence image acquisition unit, an operation unit, and a timing control circuit. The operation unit generates an optical thickness image based on an interference image acquired by the interference image acquisition unit, generates a mask image showing a region in which pixel values in a fluorescence image acquired by the fluorescence image acquisition unit are larger than a threshold value, and determines an integrated value of an optical thickness in the region shown by the mask image in the optical thickness image.
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10.发明申请公开(公告)号：US20180017370A1
公开(公告)日：2018-01-18
申请号：US15546126
申请日：2015-12-14
Applicant: HAMAMATSU PHOTONICS K.K.
Inventor： Toyohiko YAMAUCHI , Hidenao YAMADA
Abstract: An interference observation apparatus includes an interference optical apparatus , a microscope housing, an imaging unit, and an objective lens. The interference optical apparatus includes a housing, a light source, a photodetector, beam splitters, a reference mirror, and a control unit. The interference observation apparatus is configured such that the housing of the interference optical apparatus is disposed between the objective lens attachment portion and the objective lens in a microscope apparatus including the imaging unit for capturing an image of the light passing through the objective lens attached to the objective lens attachment portion having an opening.
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