公开(公告)号：US11535611B2

公开(公告)日：2022-12-27

申请号：US16955926

申请日：2018-12-19

申请人： H. Lundbeck A/S

发明人： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgård ,  Mikkel Jessing ,  Paulo Jorge Vieira Vital ,  Karsten Juhl ,  Mauro Marigo

IPC分类号： C07D401/14 ,  C07D405/14

摘要： The present invention provides compounds of formula (I) that are PDE1 enzyme inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.

公开(公告)号：US20210015794A1

公开(公告)日：2021-01-21

申请号：US17060796

申请日：2020-10-01

申请人： H. Lundbeck A/S

发明人： Jan Kehler ,  Karsten Juhl ,  Mauro Marigo ,  Paulo Jorge Vieira Vital ,  Mikkel Jessing ,  Morten Langgård ,  Lars Kyhn Rasmussen ,  Carl Martin Sebastian Clementson

IPC分类号： A61K31/4162 ,  C07D471/04 ,  A61K31/4745 ,  C07D413/04

摘要： The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (1) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

公开(公告)号：US20210009571A1

公开(公告)日：2021-01-14

申请号：US16955926

申请日：2018-12-19

申请人： H. Lundbeck A/S

发明人： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgârd ,  Mikkel Jessing ,  Paulo Jorge Vieira Vital ,  Karsten Juhl ,  Mauro Marigo

IPC分类号： C07D405/14 ,  C07D401/14

摘要： The present invention provides compounds of formula (I) that are PDE1 enzyme inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.

公开(公告)号：US20190352302A1

公开(公告)日：2019-11-21

申请号：US16424585

申请日：2019-05-29

申请人： H. Lundbeck A/S

发明人： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgård ,  Mikkel Jessing ,  Paulo Jorge Vieira Vital ,  Karsten Juhl ,  Mauro Marigo

IPC分类号： A61K31/502 ,  C07D471/04 ,  C07D519/00 ,  C07D487/04 ,  A61P25/28 ,  A61P25/00 ,  A61P25/18 ,  A61P25/16

摘要： The present invention provides compounds of formula (I) that are PDE1 enzyme inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.

公开(公告)号：US20180177793A1

公开(公告)日：2018-06-28

申请号：US15848711

申请日：2018-03-19

申请人： H. Lundbeck A/S

发明人： John Paul Kilburn ,  Lars Kyhn Rasmussen ,  Mikkel Jessing ,  Eman Mohamed Eldemenky ,  Bin Chen ,  Yu Jiang

IPC分类号： A61K31/553 ,  A61K31/4545 ,  A61K31/5375 ,  A61K31/454 ,  A61K31/40 ,  A61K31/5377 ,  A61K31/4453 ,  A61K31/506 ,  A61K31/445

CPC分类号： A61K31/553 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/625 ,  C07D209/52 ,  C07D211/38 ,  C07D213/40 ,  C07D239/26 ,  C07D267/10 ,  C07D295/13 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06

摘要： The present invention is directed to novel cyclic amines which inhibit the P2X7 receptor.

公开(公告)号：US20180000786A1

公开(公告)日：2018-01-04

申请号：US15637920

申请日：2017-06-29

申请人： H. Lundbeck A/S

发明人： Jan Kehler ,  Karsten Juhl ,  Mauro Marigo ,  Paulo Jorge Vieira Vital ,  Mikkel Jessing ,  Morten Langgård ,  Lars Kyhn Rasmussen ,  Carl Martin Sebastian Clementson

IPC分类号： A61K31/4162 ,  C07D413/04 ,  A61K31/4745 ,  C07D401/04 ,  C07D305/06

CPC分类号： A61K31/4162 ,  A61K31/4745 ,  C07D305/06 ,  C07D401/04 ,  C07D413/04 ,  C07D471/04

摘要： The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

公开(公告)号：US09701665B2

公开(公告)日：2017-07-11

申请号：US15105647

申请日：2014-12-18

申请人： H. Lundbeck A/S

发明人： Jan Kehler ,  Lars Kyhn Rasmussen ,  Morten Langgård

IPC分类号： C07D405/12

CPC分类号： C07D405/12

摘要： The present invention provides Quinazolin-THF-amines as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

公开(公告)号：US20170081333A1

公开(公告)日：2017-03-23

申请号：US15358168

申请日：2016-11-22

申请人： H. Lundbeck A/S

发明人： Niels Svenstrup ,  Klaus Baiek Simonsen ,  Lars Kyhn Rasmussen ,  Karsten Juhl ,  Morten Langgård ,  Kate Wen ,  Yazhou Wang

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  A61K31/53

摘要： This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).

公开(公告)号：US09108938B2

公开(公告)日：2015-08-18

申请号：US14050466

申请日：2013-10-10

申请人： H. Lundbeck A/S

发明人： John Paul Kilburn ,  Lars Kyhn Rasmussen ,  Mikkel Jessing ,  Eman Mohammed Eldemenky ,  Bin Chen ,  Yu Jiang

IPC分类号： C07D413/06 ,  C07D295/13 ,  C07D401/06 ,  C07D403/06 ,  C07D211/38 ,  C07D213/40 ,  C07D239/26 ,  C07D267/10 ,  C07D209/52

CPC分类号： A61K31/553 ,  A61K31/40 ,  A61K31/445 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/625 ,  C07D209/52 ,  C07D211/38 ,  C07D213/40 ,  C07D239/26 ,  C07D267/10 ,  C07D295/13 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06

摘要： The present invention is directed to novel cyclic amines which inhibit the P2X7 receptor.

摘要翻译： 本发明涉及抑制P2X7受体的新型环胺。

公开(公告)号：US11104680B2

公开(公告)日：2021-08-31

申请号：US16701269

申请日：2019-12-03

申请人： H. Lundbeck A/S

发明人： Karsten Juhl ,  Mikkel Jessing ,  Morten Langgård ,  Paulo Jorge Vieira Vital ,  Mauro Marigo ,  Jan Kehler ,  Lars Kyhn Rasmussen

IPC分类号： A61K31/437 ,  A61K31/519 ,  C07D487/04 ,  C07D471/04

摘要： The present invention provides 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.