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    PDE9 Inhibitors with Imidazo Triazinone Backbone
    6.
    发明申请
    PDE9 Inhibitors with Imidazo Triazinone Backbone 有权

    公开(公告)号：US20170081333A1

    公开(公告)日：2017-03-23

    申请号：US15358168

    申请日：2016-11-22

    申请人： H. Lundbeck A/S

    发明人： Niels Svenstrup ,  Klaus Baiek Simonsen ,  Lars Kyhn Rasmussen ,  Karsten Juhl ,  Morten Langgård ,  Kate Wen ,  Yazhou Wang

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04 ,  A61K31/53

    摘要： This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).

    Substituted imidazo[2,1-A]isoindoles as PDE10 inhibitors
    9.
    发明授权
    Substituted imidazo[2,1-A]isoindoles as PDE10 inhibitors 有权
    取代的咪唑并[2,1-A]异吲哚作为PDE10抑制剂

    公开(公告)号：US09062060B2

    公开(公告)日：2015-06-23

    申请号：US14309423

    申请日：2014-06-19

    申请人： H. Lundbeck A/S

    发明人： Jan Kehler ,  Jacob Nielsen ,  Mauro Marigo ,  John Paul Kilburn ,  Morten Langgård

    IPC分类号： C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61K31/437 ,  A61K31/4985 ,  A61K45/06

    CPC分类号： C07D487/04 ,  A61K31/437 ,  A61K31/4985 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00

    摘要： This invention is directed to compounds with the structure which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.

    摘要翻译： 本发明涉及具有PDE10A酶抑制剂结构的化合物。 本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还提供了制备式I化合物的方法。本发明还提供了治疗患有神经变性疾病的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明 本发明还提供了治疗患有药物成瘾症的受试者的方法，其包括向受试者施用治疗有效量的式I化合物。本发明还提供了治疗患有精神病障碍患者的方法，包括给予 治疗有效量的式I化合物。