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![3-oxo-tetrahydro-furo[3,2-b]pyrrol-4(5H)-yl) derivatives II](/abs-image/US/2017/10/31/US09802947B2/abs.jpg.150x150.jpg)
公开(公告)号：US09802947B2
公开(公告)日：2017-10-31
申请号：US14693975
申请日：2015-04-23
申请人： GRÜNENTHAL GMBH
发明人： Antonio Nardi , Paul Ratcliffe , Tobias Craan , Torsten Hertrampf , Bernhard Lesch , Henning Steinhagen
IPC分类号： C07D491/048
CPC分类号： C07D491/048
摘要： The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors exhibiting a pronounced CatK-inhibition, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
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公开(公告)号：US10391099B2
公开(公告)日：2019-08-27
申请号：US15354424
申请日：2016-11-17
申请人： Grünenthal GmbH
IPC分类号： A61K31/5377 , A61K31/506 , C07D403/04 , C07D403/14 , C07D471/04 , C07D401/14
摘要： The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
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![3-oxo-tetrahydro-furo[3,2-B]pyrrol-4(5H)-yl) derivatives I](/abs-image/US/2017/08/08/US09725459B2/abs.jpg.150x150.jpg)
公开(公告)号：US09725459B2
公开(公告)日：2017-08-08
申请号：US14693987
申请日：2015-04-23
申请人： GRÜNENTHAL GMBH
发明人： Antonio Nardi , Paul Ratcliffe , Tobias Craan , Torsten Hertrampf , Bernhard Lesch , Robert Kime , Henning Steinhagen
IPC分类号： C07D491/048
CPC分类号： C07D491/048
摘要： The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors. to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
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公开(公告)号：US09315490B2
公开(公告)日：2016-04-19
申请号：US14800180
申请日：2015-07-15
申请人： Grünenthal GmbH
发明人： Ingo Konetzki , Tobias Craan , Florian Jakob , Antonio Nardi , Christian Hesslinger , Andre Welbers
IPC分类号： A61K31/506 , C07D403/04 , C07D401/14 , C07D405/14 , C07D403/14 , C07D413/14 , C07D491/107 , C07D471/10 , C07D417/14 , C07D487/04 , C07D498/08
CPC分类号： C07D403/04 , A61K31/506 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107 , C07D493/10 , C07D498/08
摘要： The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
摘要翻译： 本发明涉及通式（I）的新型取代的稠合嘧啶化合物，其中化学基团，取代基和指数如说明书中所定义，以及它们作为药物的用途，特别是作为用于治疗病症和疾病的药物 可以通过PDE4酶的抑制来治疗。
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公开(公告)号：US09688683B2
公开(公告)日：2017-06-27
申请号：US15018968
申请日：2016-02-09
申请人： GRÜNENTHAL GMBH
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
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公开(公告)号：US09527832B2
公开(公告)日：2016-12-27
申请号：US14883986
申请日：2015-10-15
申请人： GRÜNENTHAL GMBH
发明人： Ingo Konetzki , Florian Jakob , Tobias Craan , Christian Hesslinger , Paul Ratcliffe , Antonio Nardi
IPC分类号： C07D413/04 , C07D403/04 , C07D495/04
CPC分类号： C07D403/04 , C07D413/04 , C07D495/04
摘要： The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
摘要翻译： 本发明涉及通式（I）的新型取代的稠合嘧啶化合物，其中化学基团，取代基和指数如说明书中所定义，以及它们作为药物的用途，特别是作为用于治疗病症和疾病的药物 可以通过PDE4酶的抑制来治疗。
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公开(公告)号：US10189854B2
公开(公告)日：2019-01-29
申请号：US15354358
申请日：2016-11-17
申请人： Grünenthal GmbH
发明人： Antonio Nardi , Florian Jakob , Ingo Konetzki , Tobias Craan , Christian Hesslinger , Robin Doodeman
IPC分类号： C07D491/107 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D487/08 , C07D487/04 , C07D487/10
摘要： The invention relates to novel substituted pyrimidine compounds of general formula (I) in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
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公开(公告)号：US09546158B2
公开(公告)日：2017-01-17
申请号：US14800252
申请日：2015-07-15
申请人： Grünenthal GmbH
IPC分类号： C07D403/04 , C07D401/14 , C07D471/04 , C07D403/14
CPC分类号： A61K31/5377 , A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D471/04
摘要： The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
摘要翻译： 其中化学基团，取代基和指数如说明书中所定义，以及它们作为药物的用途，特别是作为用于治疗可通过抑制PDE4酶治疗的病症和疾病的药物。
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公开(公告)号：US09540349B2
公开(公告)日：2017-01-10
申请号：US14800053
申请日：2015-07-15
申请人： Grünenthal GmbH
IPC分类号： C07D403/04 , C07D401/14 , C07D487/08 , C07D403/14 , C07D491/107 , C07D409/14 , C07D413/14 , C07D405/14 , C07D417/14 , C07D471/04
CPC分类号： C07D491/107 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10
摘要： The invention relates to novel substituted pyrimidine compounds of general formula (I) in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
摘要翻译： 其中化学分组，取代基，变量和指数如说明书中所定义，以及它们作为药物的用途，特别是作为治疗可通过抑制PDE4酶治疗的病症和疾病的药物。
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