公开(公告)号：US10466252B2

公开(公告)日：2019-11-05

申请号：US14176231

申请日：2014-02-10

申请人： Glaxo Group Limited

发明人： Carolyn Enever ,  Laurent Jespers ,  Malgorzata Pupecka-Swider ,  Ian Tomlinson

IPC分类号： C40B40/10 ,  G01N33/68 ,  C12N5/07 ,  C12Q1/37

摘要： The disclosure relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the serum. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, incubating the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, e.g., for treating disease in humans.

公开(公告)号：US10696738B2

公开(公告)日：2020-06-30

申请号：US15363223

申请日：2017-02-02

申请人： Glaxo Group Limited

发明人： Elena De Angelis ,  Carolyn Enever ,  Haiqun Liu ,  Oliver Schon

IPC分类号： A61K39/00 ,  C07K16/18 ,  C07K14/56 ,  C07K14/575 ,  C07K16/28

摘要： The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-11, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts.

公开(公告)号：US10302655B2

公开(公告)日：2019-05-28

申请号：US15679191

申请日：2017-08-17

申请人： Glaxo Group Limited

发明人： Carolyn Enever ,  Laurent Jespers ,  Malgorzata Pupecka-Swider ,  Ian Tomlinson

IPC分类号： C12N5/00 ,  G01N33/68 ,  C12N5/07 ,  C12Q1/37 ,  C40B40/10

摘要： The disclosure relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the serum. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, incubating the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, e.g., for treating disease in humans.

公开(公告)号：US09751935B2

公开(公告)日：2017-09-05

申请号：US14862818

申请日：2015-09-23

申请人： GLAXO GROUP LIMITED

发明人： Elena De Angelis ,  Carolyn Enever ,  Haiqun Liu ,  Oliver Schon

IPC分类号： C07K16/18 ,  C07K14/56 ,  C07K14/575 ,  C07K16/28

CPC分类号： C07K16/18 ,  C07K14/56 ,  C07K14/57563 ,  C07K16/2878 ,  C07K2317/14 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/31

摘要： The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-14, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts.

公开(公告)号：US20160075774A1

公开(公告)日：2016-03-17

申请号：US14862818

申请日：2015-09-23

申请人： Glaxo Group Limited

发明人： Elena DE ANGELIS ,  Carolyn Enever ,  Haiqun Liu ,  Oliver Schon

IPC分类号： C07K16/18

CPC分类号： C07K16/18 ,  C07K14/56 ,  C07K14/57563 ,  C07K16/2878 ,  C07K2317/14 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/31

摘要： The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-14, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts.

摘要翻译： 本发明涉及抗血清白蛋白免疫球蛋白单可变结构域DOM7h-14的改进变体，以及包含这些变体，组合物，核酸，载体和宿主的配体和药物偶联物。