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公开(公告)号：US20220227787A1
公开(公告)日：2022-07-21
申请号：US17558130
申请日：2021-12-21
发明人： Daniel H. Byun , Eda Y. Canales , Laurent P. Debien , Petr Jansa , Rick A. Lee , Jennifer A. Loyer-Drew , Stephane Perreault , Hyung-Jung Pyun , Roland D. Saito , Michael S. Sangi , Adam J. Schrier , Marina E. Shatskikh , James G. Taylor , Jennifer A. Treiberg , Joshua J. Van Veldhuizen , Lianhong Xu
IPC分类号： C07D519/00
摘要： The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：US11878965B2
公开(公告)日：2024-01-23
申请号：US17557860
申请日：2021-12-21
发明人： Daniel H. Byun , Zhenhong R. Cai , Eda Y. Canales , Laurent P. Debien , Timothy R. Hansen , Richard Huang , Petr Jansa , Rick A. Lee , Jennifer A. Loyer-Drew , Ryan McFadden , Michael L. Mitchell , Hyung-Jung Pyun , Roland D. Saito , Michael S. Sangi , Adam J. Schrier , Marina E. Shatskikh , James G. Taylor , Joshua J. Van Veldhuizen , Lianhong Xu
IPC分类号： C07D401/04 , A61K31/437 , A61K31/454 , A61K31/501 , A61K31/506 , A61K31/5355 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D519/00
CPC分类号： C07D401/04 , A61K31/437 , A61K31/454 , A61K31/501 , A61K31/506 , A61K31/5355 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D519/00
摘要： The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：US11976083B2
公开(公告)日：2024-05-07
申请号：US17242617
申请日：2021-04-28
发明人： Eda Y. Canales , Weng K. Chang , Laurent P. Debien , Petr Jansa , Jennifer A. Loyer-Drew , Luisruben P. Martinez , Stephane Perreault , Gary B Phillips , Hyung-Jung Pyun , Roland D. Saito , Michael S. Sangi , Adam J. Schrier , Marina E. Shatskikh , James G. Taylor , Jennifer A. Treiberg , Joshua J. Van Veldhuizen
IPC分类号： C07D471/18 , A61K31/4184 , A61K31/4188 , A61K31/437 , A61K45/06 , A61P3/10 , A61P7/02 , A61P19/02 , A61P35/00 , C07D471/12 , C07D471/14 , C07D487/08 , C07D491/22 , C07D498/18 , C07D498/22 , C07D513/18 , C07D519/00
CPC分类号： C07D519/00 , A61K45/06 , C07D471/14
摘要： The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：US20230090053A1
公开(公告)日：2023-03-23
申请号：US17557860
申请日：2021-12-21
发明人： Daniel H. Byun , Zhenhong R. Cai , Eda Y. Canales , Laurent P. Debien , Timothy R. Hansen , Richard Huang , Petr Jansa , Rick A. Lee , Jennifer A. Loyer-Drew , Ryan McFadden , Michael L. Mitchell , Hyung-Jung Pyun , Roland D. Saito , Michael S. Sangi , Adam J. Schrier , Marina E. Shatskikh , James G. Taylor , Joshua J. Van Veldhuizen , Lianhong Xu
IPC分类号： C07D401/04 , A61K45/06 , A61K31/437 , C07D519/00 , A61K31/5383 , C07D401/14 , A61K31/454 , A61K31/501 , A61K31/506 , A61K31/5355
摘要： The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：US20230002412A1
公开(公告)日：2023-01-05
申请号：US17242617
申请日：2021-04-28
发明人： Eda Y. Canales , Weng K. Chang , Laurent P. Debien , Petr Jansa , Jennifer A. Loyer-Drew , Luisruben P. Martinez , Stephane Perreault , Gary B. Phillips , Hyung-Jung Pyun , Roland D. Saito , Michael S. Sangi , Adam J. Schrier , Marina E. Shatskikh , James G. Taylor , Jennifer A. Treiberg , Joshua J. Van Veldhuizen
IPC分类号： C07D519/00 , C07D471/14 , A61K45/06
摘要： The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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