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1.发明申请Animal Model and Use of 17Beta-Hydroxysteroid Dehydrogenase Type 7 in the Diagnosis of Anencephaly 审中-公开动物模型和17型β-羟基甾体脱氢酶7型在麻醉诊断中的应用公开(公告)号：US20110008311A2
公开(公告)日：2011-01-13
申请号：US12607255
申请日：2009-10-28
申请人： Geula Gibori , Aurora Shehu
发明人： Geula Gibori , Aurora Shehu
IPC分类号： A61K38/44 , A01K67/027 , C12N5/10 , C12Q1/68 , A61K31/7088 , C07H21/04 , A61P25/00 , G01N33/48 , C12N9/02
CPC分类号： A61K31/7088 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , A61K38/443 , C07K14/47 , C12N9/0006 , C12N15/00 , C12N15/8509 , C12Y101/01062
摘要： The present invention features a non-human animal in which is deficient in the expression of endogenous 17β Hydroxysteroid Dehydrogenases Type 7 and use of the same in screening methods for agents that prevent or treat anencephaly. The present invention also provides a method for diagnosing and treating.
摘要翻译： 本发明特征在于一种非人动物，其内源性17和bgr的表达不足; 类固醇类脱氢酶7型及其在预防或治疗脑病的药物筛选方法中的应用。 本发明还提供了一种诊断和治疗方法。
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2.发明授权
公开(公告)号：US6001353A
公开(公告)日：1999-12-14
申请号：US853839
申请日：1997-05-09
申请人： Geula Gibori
发明人： Geula Gibori
CPC分类号： C12N9/0006 , A61K31/7084 , A61K38/443 , C12Y101/01149 , A61K38/00
摘要： The present invention relates generally to methods of inducing contraceptive or abortive effects via modulation of levels of circulating hormones via administration of an enzyme, pharmaceutical compositions achieving such effects, antibody substances immunoreactive to said enzyme and related substances, and methods for screening for the predisposition of spontaneous abortions
摘要翻译： 本发明一般涉及通过施用酶调节循环激素水平诱导避孕或堕胎作用的方法，获得这种作用的药物组合物，对所述酶和相关物质免疫反应的抗体物质，以及用于筛选 自发流产
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