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1.发明公开公开(公告)号：US20240002374A1
公开(公告)日：2024-01-04
申请号：US17742169
申请日：2022-05-11
申请人： Genzyme Corporation
发明人： Junkai Liao , Mark Munson , Zhongli Gao , Gregory Hurlbut , Sylvie Baltzer , Bertrand Vivet , Brian Freed , Hans Peter Nestler , Helen Yeoman , Ingrid Mechin , Martin Smrcina , Nina Ma , Sylvain Lebreton , Ryan Hartung , William Wire , Sukanthini Thurairatnam
IPC分类号： C07D417/12 , C07D277/52 , C07D417/04 , C07D417/14 , C07F9/22 , C07D498/10
CPC分类号： C07D417/12 , C07D277/52 , C07D498/10 , C07D417/14 , C07F9/222 , C07D417/04
摘要： The invention relates to heteroaryl compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.
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公开(公告)号：US20230147360A1
公开(公告)日：2023-05-11
申请号：US17832388
申请日：2022-06-03
申请人： Genzyme Corporation
发明人： Junkai Liao , Mark Munson , Zhongli Gao , Gregory Hurlbut , Hans Peter Nestler , Ingrid Mechin , Martin Smrcina , Ronghua Li , Ryan Hartung , William Bock , Bertrand Vivet , Andrew Scholte
IPC分类号： C07D333/54 , C07D417/12 , C07D333/64 , C07D417/04 , C07D277/64 , A61K45/06
CPC分类号： C07D333/54 , C07D417/12 , C07D333/64 , C07D417/04 , C07D277/64 , A61K45/06
摘要： The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.
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公开(公告)号：US20230159439A1
公开(公告)日：2023-05-25
申请号：US17832385
申请日：2022-06-03
申请人： Genzyme Corporation
发明人： Junkai Liao , Mark Munson , Zhongli Gao , Gregory Hurlbut , Hans Peter Nestler , Ingrid Mechin , Joseph Kim , Martin Smrcina , Nina Ma , Ronghua Li , Ryan Hartung , William Bock , Bertrand Vivet
IPC分类号： C07C235/66 , A61K45/06 , A61K31/197 , C07C323/19 , C07D215/48 , A61K31/47 , C07C309/75 , C07D333/70 , A61K31/381 , C07C309/68 , C07D277/64 , A61K31/428 , C07D417/12 , A61K31/4709 , C07D307/79 , A61K31/343 , C07D471/04 , A61K31/437 , C07D239/70 , A61K31/517 , C07D239/88
CPC分类号： C07C235/66 , A61K45/06 , A61K31/197 , C07C323/19 , C07D215/48 , A61K31/47 , C07C309/75 , C07D333/70 , A61K31/381 , C07C309/68 , C07D277/64 , A61K31/428 , C07D417/12 , A61K31/4709 , C07D307/79 , A61K31/343 , C07D471/04 , A61K31/437 , C07D239/70 , A61K31/517 , C07D239/88 , C07C2603/74 , C07C2601/14
摘要： The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.
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