公开(公告)号：US20230220491A1

公开(公告)日：2023-07-13

申请号：US18157597

申请日：2023-01-20

Applicant: Genentech, Inc.

Inventor： YounJeong CHOI ,  Omar Kabbarah ,  Doris Kim

IPC: C12Q1/6886 ,  A61K39/395 ,  C07K16/30 ,  A61K31/517 ,  C07K16/18 ,  G01N33/574 ,  C07K16/28 ,  A61K45/06

CPC classification number: C12Q1/6886 ,  A61K39/39558 ,  C07K16/3038 ,  A61K31/517 ,  C07K16/18 ,  G01N33/57407 ,  C07K16/2863 ,  A61K45/06 ,  G01N2333/71 ,  C12Q2600/158 ,  C12Q2600/118 ,  C12Q2600/106 ,  G01N2800/52 ,  G01N2333/4748

Abstract: The invention provides methods and compositions to detect expression of one or more biomarkers, including FGFR3, TP53, and/or EGFR, for treating, diagnosing, and providing a prognosis for cancer, e.g., bladder cancer. The invention also provides kits and articles of manufacture for use in the methods.

公开(公告)号：US20170226198A1

公开(公告)日：2017-08-10

申请号：US15581448

申请日：2017-04-28

Applicant: Genentech, Inc.

Inventor： Yuanyuan XIAO ,  Carlos BAIS ,  YounJeong CHOI ,  Nicola C. CONSALVO

IPC: C07K16/22 ,  A61K39/395 ,  G01N33/574 ,  A61K31/495 ,  A61K38/21 ,  C07K16/30 ,  A61K45/06

CPC classification number: C07K16/22 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/513 ,  A61K31/519 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/24 ,  A61K38/21 ,  A61K38/212 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/76 ,  G01N33/57449 ,  G01N2333/70596 ,  G01N2333/71 ,  G01N2800/52 ,  A61K2300/00

Abstract: The invention describes the use of high CD31 and/or tumor VEGFA as selection criteria for determining patient benefit or responsiveness to a VEGF antagonist, such as bevacizumab. The present invention also describes the use of high CD31 and/or tumor VEGFA as a selection criterion for treating cancer patients, such as ovarian cancer patients, who are undergoing a chemotherapy and/or anti-cancer therapy regimen, with a VEGF antagonist, such as bevacizumab.

公开(公告)号：US20220267864A1

公开(公告)日：2022-08-25

申请号：US17743230

申请日：2022-05-12

Applicant: Genentech, Inc.

Inventor： YounJeong CHOI ,  Omar KABBARAH ,  Doris KIM

IPC: C12Q1/6886 ,  A61K31/517 ,  A61K39/395 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574

Abstract: The invention provides methods and compositions to detect expression of one or more biomarkers, including FGFR3, TP53, and/or EGFR, for treating, diagnosing, and providing a prognosis for cancer, e.g., bladder cancer. The invention also provides kits and articles of manufacture for use in the methods.

公开(公告)号：US20170306418A1

公开(公告)日：2017-10-26

申请号：US15628775

申请日：2017-06-21

Applicant: Genentech, Inc.

Inventor： YounJeong CHOI ,  Omar KABBARAH ,  Doris KIM

IPC: C12Q1/68 ,  A61K45/06 ,  A61K31/517 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574 ,  A61K39/395 ,  C07K16/18

CPC classification number: C12Q1/6886 ,  A61K31/517 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/3038 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2333/4748 ,  G01N2333/71 ,  G01N2800/52

Abstract: The invention provides methods and compositions to detect expression of one or more biornarkers, including FGFR3, TP53, and/or EGFR, for treating, diagnosing, and providing a prognosis for cancer, e.g., bladder cancer. The invention also provides kits and articles of manufacture for use in the methods.