公开(公告)号：US20180209982A1

公开(公告)日：2018-07-26

申请号：US15789768

申请日：2017-10-20

Applicant: Genentech, Inc. ,  EPIC SCIENCES INC.

Inventor： Omar KABBARAH ,  Iliana SZAFER-GLUSMAN ,  Dena MARRINUCCI ,  Florence LEE ,  Shannon WERNER

IPC: G01N33/574

CPC classification number: G01N33/57434 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6871 ,  C07K16/30 ,  C07K16/40 ,  G01N2333/4742 ,  G01N2333/705 ,  G01N2333/70589 ,  G01N2333/90287 ,  G01N2800/52

Abstract: The invention provides methods for diagnosing prostate cancer. The invention also provides methods for determining the prognosis and efficacy of STEAP1-ADC therapy in patients with prostate cancer, specifically metastatic castration resistant prostate cancer (mCRPC).

公开(公告)号：US20220267864A1

公开(公告)日：2022-08-25

申请号：US17743230

申请日：2022-05-12

Applicant: Genentech, Inc.

Inventor： YounJeong CHOI ,  Omar KABBARAH ,  Doris KIM

IPC: C12Q1/6886 ,  A61K31/517 ,  A61K39/395 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574

Abstract: The invention provides methods and compositions to detect expression of one or more biomarkers, including FGFR3, TP53, and/or EGFR, for treating, diagnosing, and providing a prognosis for cancer, e.g., bladder cancer. The invention also provides kits and articles of manufacture for use in the methods.

公开(公告)号：US20170306418A1

公开(公告)日：2017-10-26

申请号：US15628775

申请日：2017-06-21

Applicant: Genentech, Inc.

Inventor： YounJeong CHOI ,  Omar KABBARAH ,  Doris KIM

IPC: C12Q1/68 ,  A61K45/06 ,  A61K31/517 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574 ,  A61K39/395 ,  C07K16/18

CPC classification number: C12Q1/6886 ,  A61K31/517 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/3038 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2333/4748 ,  G01N2333/71 ,  G01N2800/52

Abstract: The invention provides methods and compositions to detect expression of one or more biornarkers, including FGFR3, TP53, and/or EGFR, for treating, diagnosing, and providing a prognosis for cancer, e.g., bladder cancer. The invention also provides kits and articles of manufacture for use in the methods.