公开(公告)号：US20210301005A1

公开(公告)日：2021-09-30

申请号：US17205663

申请日：2021-03-18

Applicant: Genentech, Inc.

Inventor： Wei-Ching LIANG ,  Joseph R. ARRON ,  Daryle DEPIANTO ,  Wendy Green HALPERN ,  WeiYu LIN ,  Patrick J. LUPARDUS ,  Thirumalai Rajan RAMALINGAM ,  Dhaya SESHASAYEE ,  Tianhe SUN ,  Tulika TYAGI ,  Jia WU ,  Yan WU ,  Jian Ping YIN

IPC: C07K16/22 ,  A61P11/00 ,  C07K16/46

Abstract: The invention provides isoform-selective anti-TGFβ antibodies and methods of using the same. In particular, isoform-selective anti-TGFβ2, anti-TGFβ3, and anti-TGFβ2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGFβ-related disorders.

公开(公告)号：US20240327522A1

公开(公告)日：2024-10-03

申请号：US18621505

申请日：2024-03-29

Applicant: Genentech, Inc.

Inventor： WeiYu LIN ,  Kelly Michele LOYET ,  Matthieu MASUREEL ,  Minh THAI ,  Shannon Jennifer TURLEY ,  Tulika TYAGI ,  Yan WU ,  Jianhuan ZHANG ,  Alessandra CASTIGLIONI ,  Cecilia Pui Chi CHIU

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

CPC classification number: C07K16/2842 ,  A61P35/00 ,  C07K16/2818 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are anti-αvβ8 antibodies or antigen-binding portions thereof and methods of making and using the same. Further provided are methods of treating cancer with an anti-αvβ8 and a PD-1 axis antagonist.