公开(公告)号：US20240327522A1

公开(公告)日：2024-10-03

申请号：US18621505

申请日：2024-03-29

Applicant: Genentech, Inc.

Inventor： WeiYu LIN ,  Kelly Michele LOYET ,  Matthieu MASUREEL ,  Minh THAI ,  Shannon Jennifer TURLEY ,  Tulika TYAGI ,  Yan WU ,  Jianhuan ZHANG ,  Alessandra CASTIGLIONI ,  Cecilia Pui Chi CHIU

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

CPC classification number: C07K16/2842 ,  A61P35/00 ,  C07K16/2818 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein are anti-αvβ8 antibodies or antigen-binding portions thereof and methods of making and using the same. Further provided are methods of treating cancer with an anti-αvβ8 and a PD-1 axis antagonist.