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公开(公告)号：US20030003546A1
公开(公告)日：2003-01-02
申请号：US09816744
申请日：2001-03-22
Applicant: GENENTECH, INC.
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: C12Q001/68 , C12P021/02 , C07H021/04 , C12N005/06 , A61K038/20
Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Abstract translation: 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：US20030203451A1
公开(公告)日：2003-10-30
申请号：US10458442
申请日：2003-06-10
Applicant: Genentech, Inc.
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: C12P021/02 , C12N005/06 , C07K014/47 , C07K016/18 , C07H021/04 , C12N009/00
CPC classification number: A61K38/20 , C07K14/54 , C07K14/7155 , C07K2319/30 , C12N15/1136 , C12N2310/11 , C12N2310/12 , C12N2310/15
Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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Patent Agency Ranking
公开(公告)号：US20040043397A1
公开(公告)日：2004-03-04
申请号：US10408385
申请日：2003-04-07
Applicant: Genentech, Inc.
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: C12Q001/68 , C07H021/04 , C12P021/02 , C12N005/06 , C07K014/47 , C07K016/18
CPC classification number: C07K14/54
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20030185800A1
公开(公告)日：2003-10-02
申请号：US10418038
申请日：2003-04-17
Applicant: Genentech, Inc.
Inventor： Jian Chen , Paul Godowski , William I. Wood , Dong-Xiao Zhang
IPC: A61K038/21 , C07K014/56 , C07H021/04 , C12P021/04 , C12N005/06
CPC classification number: C07K14/555 , A01K2217/05 , A61K38/00 , C07K2319/00 , C07K2319/30
Abstract: The invention concerns a novel human interferon-null, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-null family and from IFNs-null and -null. Nucleic acid encoding the novel polypeptide, and methods and means for their recombinant production and use are also included.
Abstract translation: 本发明涉及一种新型人类干扰素，最初称为PRO655，其变体和衍生物。 该新型干扰素与IFN-α家族的成员和IFN-β和γ的成员相关但不同。 编码新型多肽的核酸及其重组生产和使用的方法和手段也包括在内。
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公开(公告)号：US20030180255A1
公开(公告)日：2003-09-25
申请号：US10410927
申请日：2003-04-09
Applicant: Genentech, Inc.
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: C07K014/54 , A61K038/20 , C07H021/04 , C12P021/04 , C12N005/06
Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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公开(公告)号：US20030199044A1
公开(公告)日：2003-10-23
申请号：US10410552
申请日：2003-04-08
Applicant: Genentech, Inc.
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: C12P021/02 , C12N005/06 , C07K014/54 , A61K038/20 , C07H021/04
CPC classification number: C07K14/705 , A61K38/00 , C07K14/54 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N2500/04
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20020172660A1
公开(公告)日：2002-11-21
申请号：US09919622
申请日：2001-07-30
Applicant: Genentech, Inc.
Inventor： Jian Chen , Paul Godowski , William I. Wood , Dong-Xiao Zhang
IPC: A61K038/21 , C12P021/04 , C07H021/04 , C12N005/06
CPC classification number: C07K14/555 , A01K2217/05 , A61K38/00 , C07K2319/00 , C07K2319/30
Abstract: The invention concerns a novel human interferon-null, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-null family and from IFNs-null and -null. Nucleic acid encoding the novel polypeptide, and methods and means for their recombinant production are also included.
Abstract translation: 本发明涉及一种新型的人干扰素-ε，最初命名为PRO655，其变体和衍生物。 该新型干扰素与IFN-α家族的成员和IFN-β和γ的成员相关但不同。 还包括编码新型多肽的核酸及其重组生产的方法和手段。
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