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    Polypeptides homologous to VEGF and BMPI
    1.
    发明申请
    Polypeptides homologous to VEGF and BMPI 审中-公开
    与VEGF和BMPI同源的多肽

    公开(公告)号：US20040235740A1

    公开(公告)日：2004-11-25

    申请号：US10863133

    申请日：2004-06-08

    Applicant: Genentech, Inc.

    Inventor： Napoleone Ferrara ,  Sophia S. Kuo

    IPC: A61K038/18 ,  C07K014/475 ,  C07H021/04 ,  C12N001/18 ,  C12N005/06

    CPC classification number: C07K14/52 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026

    Abstract: The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.

    Abstract translation: 本发明涉及血管内皮生长因子-E（VEGF-E）的鉴定和制备。 VEGF-E是与血管内皮生长因子（VEGF）和骨形态发生蛋白1相关的新型多肽.VC-E与VEGF具有同源性，包括对VEGF活性所需氨基酸的保守性。 VEGF-E可用于伤口修复，以及组织的产生和再生。

    Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
    3.
    发明申请
    Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis 审中-公开
    用于诊断和治疗涉及血管生成的疾病的组合物和方法

    公开(公告)号：US20040043927A1

    公开(公告)日：2004-03-04

    申请号：US10081056

    申请日：2002-02-20

    Applicant: GENENTECH, INC.

    Inventor： Kevin P. Baker ,  Napoleone Ferrara ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Weilan Ye

    IPC: A61K038/17 ,  C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435

    CPC classification number: C07K14/515 ,  A61K38/00 ,  C07K2319/00 ,  G01N2800/32

    Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogeniesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    Abstract translation: 公开了用于刺激或抑制包括人在内的哺乳动物的血管生成和/或心血管化的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。 此外，本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

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