公开(公告)号：US20220024945A1

公开(公告)日：2022-01-27

申请号：US17449398

申请日：2021-09-29

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  F. Anthony ROMERO ,  Yun-Xing CHENG ,  Wei LI

IPC: C07D498/04 ,  C07D487/04 ,  A61P11/00

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20230242530A1

公开(公告)日：2023-08-03

申请号：US18297546

申请日：2023-04-07

Applicant: Genentech, Inc.

Inventor： Simon Charles GOODACRE ,  Mark ZAK ,  F. Anthony ROMERO ,  Yun-Xing CHENG ,  Limin CHENG ,  Rongbao HUA

IPC: C07D471/04 ,  A61P11/06 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61P11/06 ,  C07D519/00

Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.

公开(公告)号：US20200339604A1

公开(公告)日：2020-10-29

申请号：US16927436

申请日：2020-07-13

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  Paul GIBBONS ,  Yun-Xing CHENG ,  Simon Charles GOODACRE

IPC: C07D519/00 ,  C07D487/04 ,  A61P11/06

Abstract: Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20200270248A1

公开(公告)日：2020-08-27

申请号：US16870602

申请日：2020-05-08

Applicant: Genentech, Inc.

Inventor： Simon Charles GOODACRE ,  Mark ZAK ,  F. Anthony ROMERO ,  Yun-Xing CHENG ,  Limin CHENG ,  Rongbao HUA

IPC: C07D471/04 ,  A61P11/06 ,  C07D519/00

Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.

公开(公告)号：US20200002346A1

公开(公告)日：2020-01-02

申请号：US16561447

申请日：2019-09-05

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  F. Anthony ROMERO ,  Po-wai YUEN ,  Emily J. HANAN

IPC: C07D487/04 ,  C07D471/04 ,  C07D491/048 ,  C07D498/04 ,  C07D513/04

Abstract: Compounds of Formula I and methods of use as Janus kinase inhibitors are described herein.

公开(公告)号：US20200062779A1

公开(公告)日：2020-02-27

申请号：US16668714

申请日：2019-10-30

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  F. Anthony ROMERO ,  Yun-Xing CHENG ,  Wei LI

IPC: C07D498/04 ,  A61P11/00 ,  C07D487/04

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20190202822A1

公开(公告)日：2019-07-04

申请号：US16293129

申请日：2019-03-05

Applicant: Genentech, Inc.

Inventor： Simon Charles GOODACRE ,  Mark ZAK ,  F. Anthony ROMERO ,  Yun-Xing CHENG ,  Limin CHENG ,  Rongbao HUA

IPC: C07D471/04 ,  C07D519/00 ,  A61P11/06

CPC classification number: C07D471/04 ,  A61P11/06 ,  C07D519/00

Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.

公开(公告)号：US20180334465A1

公开(公告)日：2018-11-22

申请号：US15984728

申请日：2018-05-21

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  F. Anthony ROMERO ,  Yun-Xing CHENG ,  Wei LI

IPC: C07D498/04

CPC classification number: C07D498/04 ,  A61P11/00 ,  C07D487/04

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20160002266A1

公开(公告)日：2016-01-07

申请号：US14382210

申请日：2013-03-01

Applicant: GENENTECH, INC. ,  FORMA TM, LLC

Inventor： Kenneth W BAIR ,  Timm R BAUMEISTER ,  Peter DRAGOVICH ,  Xiongcai LIU ,  Snahel PATEL ,  Po-Wai YUEN ,  Mark ZAK ,  Guiling ZHAO ,  Yamin ZHANG ,  Xiaozhang ZHENG

IPC: C07D519/00 ,  A61K31/438 ,  C07D495/04 ,  C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  C07D471/04 ,  C07D491/048

CPC classification number: C07D519/00 ,  A61K31/438 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04

Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

Abstract translation: 提供酰氨基螺环酰胺和磺酰胺化合物，包含这些化合物的药物组合物，以及使用这些化合物的治疗方法。

公开(公告)号：US20230206644A1

公开(公告)日：2023-06-29

申请号：US18176389

申请日：2023-02-28

Applicant: Genentech, Inc.

Inventor： Mark ZAK ,  Paul GIBBONS ,  Yun-Xing CHENG ,  Simon Charles GOODACRE

IPC: G06V20/52 ,  G06M11/00 ,  G08G1/005 ,  G08G1/04 ,  H04N7/18 ,  G06F3/147

CPC classification number: G06V20/53 ,  G06M11/00 ,  G08G1/005 ,  G08G1/04 ,  H04N7/188 ,  G06F3/147 ,  H04N7/181 ,  G09G2380/06

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.