公开(公告)号：US07500048B1

公开(公告)日：2009-03-03

申请号：US11525764

申请日：2006-09-22

Applicant: Ganesh Venkitachalam ,  Michael Cohen

Inventor： Ganesh Venkitachalam ,  Michael Cohen

IPC: G06F12/00

CPC classification number: G06F12/1036 ,  G06F12/109 ,  G06F2212/1016 ,  G06F2212/656

Abstract: Methods and systems for sharing memory pages in virtual machines are described. Guest memory pages are identified as candidate memory pages. The candidate memory pages are hashed and the hash results of the candidate memory pages are compared. A determination is made on whether a hash match exists between a first candidate memory page and a second candidate memory page. If it is determined that a hash match exists, an anonymous memory page that includes the information of candidate memory pages is created and shared. As a result, embodiments effectively reduce memory overheads by, in one example, exposing a single anonymous memory page to multiple virtual machines.

Abstract translation: 描述了在虚拟机中共享内存页的方法和系统。 访客记忆页被标识为候选记忆页。 将候选存储器页面进行散列，并比较候选存储器页面的散列结果。 确定在第一候选存储器页面和第二候选存储器页面之间是否存在哈希匹配。 如果确定存在哈希匹配，则创建并共享包括候选存储器页面的信息的匿名存储器页面。 结果，实施例通过在一个示例中将单个匿名存储器页面暴露给多个虚拟机来有效地减少存储器开销。

公开(公告)号：US08798357B2

公开(公告)日：2014-08-05

申请号：US13544817

申请日：2012-07-09

Applicant: Sudipta N Sinha ,  Hyon Lim ,  Michael Cohen ,  Matt Uyttendaele

Inventor： Sudipta N Sinha ,  Hyon Lim ,  Michael Cohen ,  Matt Uyttendaele

IPC: G06K9/00

CPC classification number: G06K9/46 ,  G06K9/00664 ,  G06T7/73 ,  G06T2207/10016 ,  G06T2207/20016 ,  G06T2207/30244

Abstract: Image-based localization technique embodiments are presented which provide a real-time approach for image-based video camera localization within large scenes that have been reconstructed offline using structure from motion or similar techniques. From monocular video, a precise 3D position and 3D orientation of the camera can be estimated on a frame by frame basis using only visual features.

Abstract translation: 提出了基于图像的定位技术实施例，其提供了使用已经使用运动或类似技术的结构离线重建的大场景内基于图像的摄像机定位的实时方法。 从单眼视频，可以使用仅视觉特征逐帧估计摄像机的精确3D位置和3D取向。

公开(公告)号：US20130302887A1

公开(公告)日：2013-11-14

申请号：US13947884

申请日：2013-07-22

Applicant: Michael Shamblott ,  Michael Cohen

Inventor： Michael Shamblott ,  Michael Cohen

IPC: C12N5/0735

CPC classification number: C12N5/0606 ,  C12N2502/04 ,  C12N2533/54

Abstract: Methods for deriving and cultivating human embryonic stem (ES) cells and maintaining their pluripotency in culture is provided by utilizing secreted products obtained from the culture medium of human embryonic gem (EG) cell derivatives, such as embryoid body-derived cells. Substrates include compounds such as collagen I, fibronectin, or superfibronectin, or extracellular matrix, typically human derived.

Abstract translation: 通过使用从人胚胎宝石（EG）细胞衍生物（例如胚状体衍生细胞）的培养基获得的分泌产物，提供用于衍生和培养人胚胎干（ES）细胞并维持其培养多能性的方法。 底物包括诸如胶原I，纤连蛋白或超纤连蛋白的化合物，或通常人衍生的细胞外基质。

公开(公告)号：US08572606B1

公开(公告)日：2013-10-29

申请号：US11365012

申请日：2006-03-01

Applicant: Ole Agesen ,  Michael Cohen ,  Jeffrey W. Sheldon

Inventor： Ole Agesen ,  Michael Cohen ,  Jeffrey W. Sheldon

IPC: G06F9/455

CPC classification number: G06F11/1402 ,  G06F9/45516 ,  G06F11/004 ,  G06F2201/815 ,  G06F2201/82

Abstract: A system and method for reducing the likelihood of concurrency errors by identifying vulnerable segments of computer code and stalling other virtual machine threads of execution. According to one embodiment of the present invention, the vulnerable segment is identified at runtime, for example in a dynamic translator. According to another embodiment of the present invention, the vulnerable segment is identified ahead of time, for example in a static translator. According to yet another embodiment of the present invention, the vulnerable segment is identified in the binary translator of a virtual machine monitor.

Abstract translation: 通过识别计算机代码的易受攻击的部分并拖延执行其他虚拟机线程来减少并发错误的可能性的系统和方法。 根据本发明的一个实施例，在运行时识别易受攻击的段，例如在动态翻译器中。 根据本发明的另一个实施例，提前识别易受攻击的段，例如在静态转换器中。 根据本发明的另一个实施例，在虚拟机监视器的二进制转换器中识别易受攻击的段。

公开(公告)号：US20120034183A1

公开(公告)日：2012-02-09

申请号：US12448435

申请日：2007-12-19

Applicant: Michael Cohen ,  Jacob Cohen

Inventor： Michael Cohen ,  Jacob Cohen

IPC: A61K38/19 ,  A61K8/66 ,  A61Q19/08 ,  A61P17/00 ,  A61Q19/00 ,  A61K38/48 ,  A61K8/67

CPC classification number: A61K8/365 ,  A61K8/64 ,  A61K8/66 ,  A61K8/981 ,  A61K9/0014 ,  A61K9/06 ,  A61K35/54 ,  A61K38/00 ,  A61K45/06 ,  A61Q19/08

Abstract: Compositions including topical formulations comprising secreted products obtained from the culture medium of human embryonic germ (EG) cell derivatives and particular combinations of components therefrom are provided for treatment of various dermatological conditions, such as adverse consequences of aging, wrinkling, altered pigmentation, altered viscoelasticity, and altered thickness, among others. Methods for using the compositions and topical formulations for treating adverse or undesirable dermatological conditions are also provided, as well as preventing the appearance of undesirable dermatological conditions.

Abstract translation: 提供包括由人类胚胎（EG）细胞衍生物的培养基获得的分泌产物和其组分的特定组合的包含局部制剂的组合物用于治疗各种皮肤病学条件，例如老化，起皱，改变的色素沉着，改变的粘弹性的不良后果 ，厚度变化等。 还提供了使用组合物和局部制剂治疗不利或不期望的皮肤病学条件的方法，以及防止不期望的皮肤病学病症的出现。

公开(公告)号：US20110173851A1

公开(公告)日：2011-07-21

申请号：US12691382

申请日：2010-01-21

Applicant: Michael Cohen

Inventor： Michael Cohen

IPC: G09F17/00 ,  G09F19/02

CPC classification number: G09F19/02

Abstract: An article, such as a towel, having an opening to secure a twirling mechanism thereto. The twirling mechanism having a handle extending from a bottom portion thereof and having a mechanism to permit rotating of the handle with respect to the fabric-article, such that the fabric article is capable of twirling around the twirling mechanism. The twirling mechanism may in other embodiments include noise maker when the handle is rotated.

Abstract translation: 诸如毛巾的物品，具有用于固定旋转机构的开口。 旋转机构具有从其底部延伸的手柄，并且具有允许手柄相对于织物制品旋转的机构，使得织物制品能够绕旋转机构旋转。 在其他实施例中，旋转机构可以包括手柄旋转时的噪音制造器。

公开(公告)号：US07961983B2

公开(公告)日：2011-06-14

申请号：US11779871

申请日：2007-07-18

Applicant: Matthew Uyttendaele ,  Michael Cohen

Inventor： Matthew Uyttendaele ,  Michael Cohen

IPC: G06K9/00 ,  G06K9/36 ,  G06K9/32

CPC classification number: G06T3/4038

Abstract: A gigapixel image is generated from a set of images in raw format depicting different portions of a panoramic scene that has up to a full spherical field of view. Radiometric alignment of the images creates a set of images in radiance format. Geometric alignment of the radiance format images creates a set of true poses for the images in radiance format. A gigapixel image depicting the entire scene is assembled from the set of radiance format images and radiance format true poses for the images. The set of images in raw format is captured using a conventional digital camera, equipped with a telephoto lens, attached to a motorized head. The head is programmed to pan and tilt the camera in prescribed increments to individually capture the images at a plurality of exposures and with a prescribed overlap between images depicting adjacent portions of the scene.

Abstract translation: 从原始格式的一组图像生成一个千兆像素图，描绘具有全球面视野的全景场景的不同部分。 图像的放射线对准会以辐射格式创建一组图像。 辐射格式图像的几何对齐为辐射格式的图像创建一组真实姿势。 描绘整个场景的百万像素图像是由一组辐射格式图像和辐射格式组合而成的图像的真实姿势。 原始格式的图像集是使用配有远摄镜头的常规数码相机来捕捉的，该长焦镜头连接到电动头部。 头被编程为以规定的增量平移和倾斜相机，以单独地以多次曝光并且以描绘场景的相邻部分的图像之间的规定的重叠来捕获图像。

公开(公告)号：US07729256B2

公开(公告)日：2010-06-01

申请号：US11180879

申请日：2005-07-13

Applicant: Patrick J. Malloy ,  Michael Cohen ,  Alain J. Cohen

Inventor： Patrick J. Malloy ,  Michael Cohen ,  Alain J. Cohen

IPC: G01R31/08 ,  G06F15/173

CPC classification number: H04L63/0236 ,  H04L1/18 ,  H04L63/1416 ,  H04L2012/565

Abstract: A system/method searches a traffic stream for a sequence of “matching” packets that exhibit a high degree of correlation or similarity to a sequence of “reference” packets. The correlation between matching and reference packets is based on a degree of correspondence between individual packets, as well as the sequence-order of the corresponding packets. A variation of the Needleman-Wunsch algorithm is preferably used to select corresponding packets in the traffic stream that provide a sequence-order that best matches the sequence-order of the reference packets, based on a measure of the correspondence for each match, and a penalty associated with each non-match. The algorithm is further modified to reduce the required search-space for finding corresponding packets in the traffic stream.

Abstract translation: 系统/方法在业务流中搜索与“参考”分组的序列呈现高度相关性或相似性的“匹配”分组序列。 匹配和参考分组之间的相关性基于各个分组之间的对应程度以及相应分组的顺序。 Needleman-Wunsch算法的变体优选地用于基于每个匹配的对应度的度量来选择提供与参考分组的序列顺序最佳匹配的序列顺序的业务流中的相应分组，以及 与每个不匹配相关的罚款。 该算法被进一步修改以减少用于在流量流中找到相应分组的所需搜索空间。

公开(公告)号：US07687506B2

公开(公告)日：2010-03-30

申请号：US10552847

申请日：2004-04-12

Applicant: Jack Taunton ,  Michael Cohen ,  Kevan Shokat ,  Chao Zhang

Inventor： Jack Taunton ,  Michael Cohen ,  Kevan Shokat ,  Chao Zhang

IPC: C07D487/04 ,  A61K31/52

CPC classification number: C07D487/04

Abstract: Inhibition of protein kinases having one or more cysteine residues within the ATP binding site is effected by contacting the kinase, per se or in a cell or subject, with an inhibitory-effective amount of a compound having a heterocyclic core structure comprised of two or more fused rings containing at least one nitrogen ring atom, and an electrophilic substituent that is capable of reacting with a cysteine residue within the ATP binding site of a kinase. Preferred compounds include certain pyrrolopyrimidines and oxindoles having such an electrophilic substituent and optionally an aromatic or heteroaromatic substituent that is capable of interacting with a threonine or smaller residue located in the gatekeeper position of the kinase. Kinases lacking such cysteine residues may be engineered or modified so that they are capable of being inhibited by such compounds by replacing a valine or other amino acid residue within the ATP binding site by a cysteine residue.

Abstract translation: 在ATP结合位点内具有一个或多个半胱氨酸残基的蛋白激酶的抑制通过使本身或细胞或受试者中的激酶与抑制有效量的具有由两个或更多个的杂环核心结构组成的化合物接触来实现 含有至少一个氮环原子的稠环，以及能够与激酶的ATP结合位点内的半胱氨酸残基反应的亲电取代基。 优选的化合物包括具有这样的亲电子取代基的某些吡咯并嘧啶和羟吲哚，以及任选的能够与位于激酶的关守位置的苏氨酸或更小残基相互作用的芳族或杂芳族取代基。 缺乏这种半胱氨酸残基的激酶可以被改造或修饰，使得它们能够被这样的化合物抑制，通过用半胱氨酸残基替换ATP结合位点内的缬氨酸或其它氨基酸残基。

公开(公告)号：US20100075417A1

公开(公告)日：2010-03-25

申请号：US12454263

申请日：2009-05-14

Applicant: Michael Cohen ,  Xiangcan Zhan ,  Michael J. Shamblott

Inventor： Michael Cohen ,  Xiangcan Zhan ,  Michael J. Shamblott

IPC: C12N5/0735 ,  C12M1/12

CPC classification number: C12N5/0606

Abstract: Methods, devices and kits are provided for isolating or enriching multicellular embryonic stem (ES) cell colonies from a mixture of multicellular ES cell colonies and single ES cells present in a cellular suspension, by utilizing a filtration matrix that selectively excludes passage of multicellular ES cell colonies. Isolated or enriched multicellular ES cell colonies can be used for propagating pluripotent ES cells.

Abstract translation: 提供了方法，装置和试剂盒，用于通过使用选择性排除多细胞ES细胞通过的过滤基质从多细胞ES细胞集落和存在于细胞悬液中的单个ES细胞的混合物中分离或富集多细胞胚胎干细胞集落 群落。 分离或富集的多细胞ES细胞集落可用于繁殖多能ES细胞。