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公开(公告)号：US20150190521A1
公开(公告)日：2015-07-09
申请号：US14459312
申请日：2014-08-14
Applicant: Glaxosmithkline Biologicals S.A.
Inventor： Ralph Leon BIEMANS , Nathalie Marie-Josephe GARCON , Philippe Vincent HERMAND , Jan POOLMAN , Marcelle Paulette VAN MECHELEN
CPC classification number: A61K39/385 , A61K39/092 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/545 , A61K2039/55 , A61K2039/555 , A61K2039/55566 , A61K2039/575 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/62 , A61K2039/627 , A61K2039/70 , Y02A50/412
Abstract: The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, an immunogenic composition for infants is provided comprising a multivalent Streptococcus pneumoniae vaccine comprising 2 or more capsular saccharide conjugates from different serotypes, wherein the composition comprises a serotype 22F saccharide conjugate. Such a vaccine may be used in infant populations to reduce the incidence of elderly pneumococcal disease such as exacerbations of COPD and/or IPD.
Abstract translation: 本发明在肺炎球菌荚膜糖结合疫苗领域。 具体地，提供了一种用于婴儿的免疫原性组合物，其包含多价肺炎链球菌疫苗，其包含来自不同血清型的2种或更多种荚膜糖共轭物，其中所述组合物包含血清型22F糖结合物。 这样的疫苗可以用于婴儿，以减少老年肺炎球菌疾病的发生率，例如COPD和/或IPD的恶化。
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2.发明申请FUSION PROTEINS AND COMBINATION VACCINES COMPRISING HAEMOPHILUS INFLUENZAE PROTEIN E AND PILIN A 有权融合蛋白和包含HAEMOPHILUS INFLUENZAE蛋白E和PILIN A的组合疫苗公开(公告)号：US20150166613A1
公开(公告)日：2015-06-18
申请号：US14571546
申请日：2014-12-16
Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.
Inventor： Normand BLAIS , Steve LABBE , Jan POOLMAN
IPC: C07K14/285
CPC classification number: C07K14/285 , A61K39/00 , A61K39/0011 , A61K39/102 , A61K2039/54 , A61K2039/543 , A61K2039/55544 , A61K2039/55566 , A61K2039/575 , A61K2039/70 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C07K2319/50 , C07K2319/74
Abstract: The present invention relates to compositions comprising Haemophilus influenzae Protein E and Pilin A. More particularly, the present application relates to fusion proteins and immunogenic compositions comprising Protein E and PilA, vaccines comprising such immunogenic compositions and therapeutic uses of the same.
Abstract translation: 本发明涉及包含流感嗜血杆菌蛋白E和Pilin A的组合物。更具体地，本申请涉及包含蛋白E和PilA的融合蛋白和免疫原性组合物，包含这种免疫原性组合物的疫苗及其治疗用途。
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公开(公告)号：US20180207262A1
公开(公告)日：2018-07-26
申请号：US15869742
申请日：2018-01-12
Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.
Inventor： Ralph Leon BIEMANS , Nathalie Marie-Josephe GARCON , Philippe Vincent HERMAND , Jan POOLMAN , Marcelle Paulette VAN MECHELEN
IPC: A61K39/385 , A61K47/64 , A61K39/09 , A61K39/00
CPC classification number: A61K39/385 , A61K39/092 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/545 , A61K2039/55 , A61K2039/555 , A61K2039/55566 , A61K2039/575 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/62 , A61K2039/627 , A61K2039/70 , Y02A50/412
Abstract: The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, an immunogenic composition for infants is provided comprising a multivalent Streptococcus pneumoniae vaccine comprising 2 or more capsular saccharide conjugates from different serotypes, wherein the composition comprises a serotype 22F saccharide conjugate. Such a vaccine may be used in infant populations to reduce the incidence of elderly pneumococcal disease such as exacerbations of COPD and/or IPD.
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4.发明申请FUSION PROTEINS AND COMBINATION VACCINES COMPRISING HAEMOPHILUS INFLUENZAE PROTEIN E AND PILIN A 审中-公开融合蛋白和包含HAEMOPHILUS INFLUENZAE蛋白E和PILIN A的组合疫苗公开(公告)号：US20170029472A1
公开(公告)日：2017-02-02
申请号：US15197952
申请日：2016-06-30
Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.
Inventor： Normand BLAIS , Steve LABBE , Jan POOLMAN
IPC: C07K14/285 , A61K39/102
CPC classification number: C07K14/285 , A61K39/00 , A61K39/0011 , A61K39/102 , A61K2039/54 , A61K2039/543 , A61K2039/55544 , A61K2039/55566 , A61K2039/575 , A61K2039/70 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C07K2319/50 , C07K2319/74
Abstract: The present invention relates to compositions comprising Haemophilus influenzae Protein E and Pilin A. More particularly, the present application relates to fusion proteins and immunogenic compositions comprising Protein E and PilA, vaccines comprising such immunogenic compositions and therapeutic uses of the same.
Abstract translation: 本发明涉及包含流感嗜血杆菌蛋白E和Pilin A的组合物。更具体地，本申请涉及包含蛋白E和PilA的融合蛋白和免疫原性组合物，包含这种免疫原性组合物的疫苗及其治疗用途。
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5.发明申请公开(公告)号：US20150175670A1
公开(公告)日：2015-06-25
申请号：US14571807
申请日：2014-12-16
Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.
Inventor： Normand BLAIS , Steve LABBE , Jan POOLMAN
IPC: C07K14/285
CPC classification number: C07K14/285 , A61K39/00 , A61K39/0011 , A61K39/102 , A61K2039/54 , A61K2039/543 , A61K2039/55544 , A61K2039/55566 , A61K2039/575 , A61K2039/70 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C07K2319/50 , C07K2319/74
Abstract: The present invention relates to compositions comprising Haemophilus influenzae Protein E and Pilin A. More particularly, the present application relates to fusion proteins and immunogenic compositions comprising Protein E and PilA, vaccines comprising such immunogenic compositions and therapeutic uses of the same.
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Patent Agency Ranking
公开(公告)号：US20190008943A1
公开(公告)日：2019-01-10
申请号：US16011222
申请日：2018-06-18
Applicant: GlaxoSmithKline Biologicals, S.A. , Utrecht University
Inventor： Jan POOLMAN , Nathalie Isabelle DEVOS , Michiel STORK , Johannes Petrus Maria TOMMASSEN , Vincent WEYNANTS
IPC: A61K39/095 , C07K14/22
Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.
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公开(公告)号：US20180250389A9
公开(公告)日：2018-09-06
申请号：US14987770
申请日：2016-01-05
Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.
Inventor： Ralph Leon BIEMANS , Nathalie Marie-Josephe GARCON , Philippe Vincent HERMAND , Jan POOLMAN , Marcelle Paulette VAN MECHELEN
IPC: A61K39/385 , A61K39/09 , A61K47/48
CPC classification number: A61K39/385 , A61K39/092 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/545 , A61K2039/55 , A61K2039/555 , A61K2039/55566 , A61K2039/575 , A61K2039/6031 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/62 , A61K2039/627 , A61K2039/70 , Y02A50/412
Abstract: The present invention discloses an immunogenic composition comprising S. pneumoniae capsular saccharide conjugates from serotypes 19A and 19F wherein 19A is conjugated to a first bacterial toxoid and 19F is conjugated to a second bacterial toxoid. Vaccines, methods of making vaccines and uses of the vaccines are also described.
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公开(公告)号：US20170080075A1
公开(公告)日：2017-03-23
申请号：US15140879
申请日：2016-04-28
Applicant: GlaxoSmithKline Biologicals, S.A. , Utrecht University
Inventor： Jan POOLMAN , Nathalie Isabelle DEVOS , Michiel STORK , Johannes Petrus Maria TOMMASSEN , Vincent WEYNANTS
IPC: A61K39/095 , C07K16/12
CPC classification number: A61K39/095 , A61K39/00 , C07K14/195 , C07K14/22 , C07K16/1217 , Y02A50/401 , Y02A50/476 , Y02A50/478
Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.
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9.发明申请公开(公告)号：US20160250313A1
公开(公告)日：2016-09-01
申请号：US15046908
申请日：2016-02-18
Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.
Inventor： Normand BLAIS , Steve LABBE , Jan POOLMAN
IPC: A61K39/102
CPC classification number: C07K14/285 , A61K39/00 , A61K39/0011 , A61K39/102 , A61K2039/54 , A61K2039/543 , A61K2039/55544 , A61K2039/55566 , A61K2039/575 , A61K2039/70 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C07K2319/50 , C07K2319/74
Abstract: The present invention relates to compositions comprising Haemophilus influenzae Protein E and Pilin A. More particularly, the present application relates to fusion proteins and immunogenic compositions comprising Protein E and PilA, vaccines comprising such immunogenic compositions and therapeutic uses of the same.
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10.发明申请公开(公告)号：US20180222946A1
公开(公告)日：2018-08-09
申请号：US15861789
申请日：2018-01-04
Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.
Inventor： Normand BLAIS , Steve LABBE , Jan POOLMAN
IPC: C07K14/285 , A61K39/102 , A61K39/00
Abstract: The present invention relates to compositions comprising Haemophilus influenzae Protein E and Pilin A. More particularly, the present application relates to fusion proteins and immunogenic compositions comprising Protein E and PilA, vaccines comprising such immunogenic compositions and therapeutic uses of the same.
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