公开(公告)号：US20140357627A1

公开(公告)日：2014-12-04

申请号：US14300189

申请日：2014-06-09

Applicant: Gilead Connecticut, Inc.

Inventor： Scott A. MITCHELL ,  Kevin S. CURRIE ,  Peter A. BLOMGREN ,  Jeffrey E. KROPF ,  Seung H. LEE ,  Jianjun XU ,  Douglas G. STAFFORD ,  James P. HARDING ,  Antonio J.M. BARBOSA, Jr. ,  Zhongdong ZHAO ,  David M. ARMISTEAD ,  Soumya MITRA

IPC: C07D498/04 ,  G01N33/573 ,  C12Q1/48

CPC classification number: C07D487/04 ,  A61K31/495 ,  C07D471/04 ,  C07D491/107 ,  C07D498/04 ,  C07D519/00 ,  C12Q1/485 ,  G01N33/573 ,  G01N2333/91205

Abstract: Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

Abstract translation: 本文提供了某些咪唑并嗪及其药物组合物。 治疗患有某些对抑制Syk活性有作用的疾病和病症的患者的方法，其包括给予这些患者一定量的至少一种有效减少疾病或病症体征或症状的化学实​​体。 还提供了用于确定样品中Syk激酶的存在或不存在的方法。

公开(公告)号：US20140336169A1

公开(公告)日：2014-11-13

申请号：US14274618

申请日：2014-05-09

Applicant: GILEAD CONNECTICUT, INC.

Inventor： Scott A. MITCHELL ,  Kevin S. CURRIE ,  Peter A. BLOMGREN ,  Jeffrey E. KROPF ,  Seung H. LEE ,  Jianjun XU ,  Douglas G. STAFFORD ,  James P. HARDING ,  Antonio J. M. BARBOSA, JR. ,  Zhongdong ZHAO ,  David M. ARMISTEAD ,  Soumya MITRA

IPC: C07D487/04 ,  C07D498/04 ,  C07D491/107 ,  C07D471/04

CPC classification number: C07D487/04 ,  A61K31/495 ,  C07D471/04 ,  C07D491/107 ,  C07D498/04 ,  C07D519/00 ,  C12Q1/485 ,  G01N33/573 ,  G01N2333/91205

Abstract: Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

公开(公告)号：US20130267496A1

公开(公告)日：2013-10-10

申请号：US13901523

申请日：2013-05-23

Applicant: Gilead Connecticut, Inc.

Inventor： Scott A. MITCHELL ,  Kevin S. CURRIE ,  Peter A. BLOMGREN ,  Jeffrey E. KROPF ,  Seung H. LEE ,  Jianjun XU ,  Douglas G. STAFFORD ,  James P. HARDING ,  Antonio J. M. BARBOSA, JR. ,  Zhongdong ZHAO ,  David M. ARMISTEAD ,  Soumya MITRA

IPC: C07D487/04 ,  C07D498/04 ,  C07D498/08 ,  C07D471/04 ,  C07D491/107

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D498/04 ,  C07D498/08 ,  C07D519/00

Abstract: Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

公开(公告)号：US20130237521A1

公开(公告)日：2013-09-12

申请号：US13868971

申请日：2013-04-23

Applicant: GILEAD CONNECTICUT, INC.

Inventor： Scott A. MITCHELL ,  Kevin S. CURRIE ,  Peter A. BLOMGREN ,  Jeffrey E. KROPF ,  Seung H. LEE ,  Jianjun XU ,  Douglas G. STAFFORD ,  James P. HARDING ,  Antonio J. M. BARBOSA, JR. ,  Zhongdong ZHAO ,  David M. ARMISTEAD ,  Soumya MITRA

IPC: C07D487/04 ,  C07D471/04 ,  C07D498/04 ,  C07D491/107

CPC classification number: C07D487/04 ,  A61K31/495 ,  C07D471/04 ,  C07D491/107 ,  C07D498/04 ,  C07D519/00 ,  C12Q1/485 ,  G01N33/573 ,  G01N2333/91205

Abstract: Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

Abstract translation: 本文提供了某些咪唑并嗪及其药物组合物。 治疗患有某些对抑制Syk活性有作用的疾病和病症的患者的方法，其包括给予这些患者一定量的至少一种有效减少疾病或病症体征或症状的化学实​​体。 还提供了用于确定样品中Syk激酶的存在或不存在的方法。

公开(公告)号：US20130310363A1

公开(公告)日：2013-11-21

申请号：US13862194

申请日：2013-04-12

Applicant: Gilead Connecticut, Inc.

Inventor： Scott A. MITCHELL ,  Kevin S. CURRIE ,  Peter A. BLOMGREN ,  Jeffrey E. KROPF ,  Seung H. LEE ,  Jianjun XU ,  Douglas G. STAFFORD

IPC: C07D487/04

CPC classification number: C07D519/00 ,  A61K9/0053 ,  C07D471/04 ,  C07D487/04 ,  G01N2333/9121

Abstract: Certain imidazopyrazines of Formula (I): or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

Abstract translation: 本文提供了式（I）的某些咪唑并吡嗪或其药学上可接受的盐及其药物组合物。 治疗患有某些对抑制Syk活性有作用的疾病和病症的患者的方法，其包括给予这些患者一定量的至少一种有效减少疾病或病症体征或症状的化学实​​体。 还提供了用于确定样品中Syk激酶的存在或不存在的方法。

公开(公告)号：US20130237520A1

公开(公告)日：2013-09-12

申请号：US13868967

申请日：2013-04-23

Applicant: GILEAD CONNECTICUT, INC.

Inventor： Scott A. MITCHELL ,  Kevin S. CURRIE ,  Peter A. BLOMGREN ,  Jeffrey E. KROPF ,  Seung H. LEE ,  Jianjun XU ,  Douglas G. STAFFORD ,  James P. HARDING ,  Antonio J.M. BARBOSA, JR. ,  Zhongdong ZHAO ,  David M. ARMISTEAD ,  Soumya MITRA

IPC: C07D487/04 ,  C12Q1/48 ,  C07D498/04

CPC classification number: C07D487/04 ,  A61K31/495 ,  C07D471/04 ,  C07D491/107 ,  C07D498/04 ,  C07D519/00 ,  C12Q1/485 ,  G01N33/573 ,  G01N2333/91205

Abstract: Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

公开(公告)号：US20130231330A1

公开(公告)日：2013-09-05

申请号：US13862147

申请日：2013-04-12

Applicant: GILEAD CONNECTICUT, INC.

Inventor： Scott A. MITCHELL ,  Kevin S. CURRIE ,  Peter A. BLOMGREN ,  Jeffrey E. KROPF ,  Seung H. LEE ,  Jianjun XU ,  Douglas G. STAFFORD

IPC: C07D487/04 ,  C07D519/00

CPC classification number: C07D519/00 ,  A61K9/0053 ,  C07D471/04 ,  C07D487/04 ,  G01N2333/9121

Abstract: Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.