公开(公告)号：US20240142444A1

公开(公告)日：2024-05-02

申请号：US17622403

申请日：2020-06-25

Applicant: GEORGE MASON UNIVERSITY

Inventor： Lance LIOTTA ,  Marissa A. HOWARD ,  Alessandra Luchini KUNKEL ,  Sameen YUSUF ,  Sara SHARIF ,  Ruben MAGNI

IPC: G01N33/543 ,  G01N33/569

CPC classification number: G01N33/54346 ,  G01N33/56905 ,  G01N33/56911 ,  G01N33/5695 ,  G01N2333/20 ,  G01N2333/35

Abstract: The invention relates to a relates to a highly sensitive, non-invasive diagnostic method for detection infectious diseases. In one embodiment, the invention relates to novel rapid, self-working, visual field test for a panel of disease specific derived biomarkers. In one embodiment, the invention comprises a collecting device comprising a collapsible non hygroscopic net tethered with immobilized nanoparticles to capture and concentrate a target analyte present in a fluid; wherein the nanoparticle comprises a core and a shell, wherein the core comprises a molecular bait. The invention also relates to identification of biomarkers for identification of various pathogenic diseases.

公开(公告)号：US20190352351A1

公开(公告)日：2019-11-21

申请号：US15776932

申请日：2016-11-18

Applicant: GEORGE MASON UNIVERSITY

Inventor： Lance LIOTTA ,  Alessandra LUCHINI ,  Virginia ESPINA ,  Mikell PAIGE

IPC: C07K14/47 ,  C07D307/91

Abstract: In one aspect, the invention relates to compositions comprising peptides and/or peptidomimetic compounds, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, arthritis, obstructive lung disease, psoriasis, asthma, a defect in hematopoiesis, a neoplasia, a fungal infection, a parasitic infection, or an autoimmune disease, such as, but not limited to, rheumatoid arthritis, atopic allergy, anaphylaxis, psoriasis, asthma, lupus erythematosis, a myeloid cell disorder, or a eosinophil cell disorder. In an aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-1RAcP with the ST2 and IL33 receptor/cytokine complexes. In a further aspect, the disclosed peptides and/or compounds inhibit the interaction of IL-1RAcP with the IL-1R1 and IL-1β receptor/cytokine complexes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.