公开(公告)号：US20020182673A1

公开(公告)日：2002-12-05

申请号：US10000157

申请日：2001-10-30

Applicant: GENENTECH, INC.

Inventor： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Dorothy French ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Sarah G. Hymowitz ,  Hanzhong Li ,  James Pan ,  Melissa A. Starovasnik ,  Daniel Tumas ,  Menno Van Lookeren ,  Richard Vandlen ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel G. Yansura

IPC: C07K014/715 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC classification number: C07H21/04 ,  C07K16/244

Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

Abstract translation: 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

公开(公告)号：US20030203451A1

公开(公告)日：2003-10-30

申请号：US10458442

申请日：2003-06-10

Applicant: Genentech, Inc.

Inventor： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gurney ,  Hanzhong Li ,  Kenneth Hillan ,  Sarah G. Hymowitz ,  Daniel Tumas ,  Melissa A. Starovasnik ,  Menno VanLookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel Yansura

IPC: C12P021/02 ,  C12N005/06 ,  C07K014/47 ,  C07K016/18 ,  C07H021/04 ,  C12N009/00

CPC classification number: A61K38/20 ,  C07K14/54 ,  C07K14/7155 ,  C07K2319/30 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/15

Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

公开(公告)号：US20020177188A1

公开(公告)日：2002-11-28

申请号：US09874503

申请日：2001-06-05

Applicant: GENENTECH, INC.

Inventor： Jian Chen ,  Ellen Filvaroff ,  Sherman Fong ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin Gurney ,  Hanzhong Li ,  Kenneth Hillan ,  Sarah G. Hymowitz ,  Daniel Tumas ,  Melissa A. Starvovasnik ,  Menno Van Lookeren ,  Richard Vandlen ,  Colin Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Daniel G. Yansura

IPC: C07K014/715 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC classification number: C07H21/04 ,  C07K14/715 ,  C12N5/06 ,  C12P21/02

Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

Abstract translation: 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。