公开(公告)号：USRE48558E1

公开(公告)日：2021-05-18

申请号：US15908703

申请日：2018-02-28

Applicant: GENENTECH, INC.

Inventor： Yvonne Chen ,  Mark Dennis ,  David Dornan ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: A61K51/00 ,  A61K39/44 ,  C07K19/00 ,  C07K16/28 ,  A61K47/68 ,  A61K31/537 ,  A61K38/05 ,  A61K39/395 ,  A61K45/06 ,  A61K51/10 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00

Abstract: The present invention is directed to compositions of matter comprising immunoconjugates comprising an anti-CD79b antibody comprising: (i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO: 194), (ii) an HVR-L2 sequence of AASNLES (SEQ ID NO: 195), (iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO: 196), (iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO: 202), (v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO: 203), and (vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO: 204) and to methods of using those compositions of matter for the treatment of hematopoietic tumor in mammals.

公开(公告)号：US10544218B2

公开(公告)日：2020-01-28

申请号：US15349964

申请日：2016-11-11

Applicant: Genentech, Inc.

Inventor： Yvonne Chen ,  Mark Dennis ,  David Dornan ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: A61K39/395 ,  A61K39/40 ,  A61K39/42 ,  C07K16/28 ,  A61K38/05 ,  A61K31/537 ,  C07K16/30 ,  A61K51/10 ,  G01N33/574 ,  A61K45/06 ,  A61K47/68 ,  C07K16/00 ,  C12P21/08 ,  A61K39/00

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20190276550A9

公开(公告)日：2019-09-12

申请号：US13973669

申请日：2013-08-22

Applicant: Genentech, Inc.

Inventor： Yvonne Chen ,  Mark Dennis ,  David Dornan ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20140335107A1

公开(公告)日：2014-11-13

申请号：US14219473

申请日：2014-03-19

Applicant: GENENTECH, INC.

Inventor： Yvonne Chen ,  Mark Dennis ,  David Dornan ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson

IPC: C07K16/28 ,  G01N33/574

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

Abstract translation: 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。

公开(公告)号：US20140099260A1

公开(公告)日：2014-04-10

申请号：US13973669

申请日：2013-08-22

Applicant: Genentech, Inc.

Inventor： Yvonne Chen ,  Mark Dennis ,  David Dornan ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/2803 ,  A61K31/537 ,  A61K38/05 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6867 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/2896 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/92 ,  G01N33/57492 ,  Y02A50/412 ,  Y02A50/423

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

Abstract translation: 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。

公开(公告)号：US09896506B2

公开(公告)日：2018-02-20

申请号：US14734957

申请日：2015-06-09

Applicant: Genentech, Inc.

Inventor： Yvonne Chen ,  Mark Dennis ,  David Dornan ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K47/68 ,  A61K38/05 ,  A61K45/06 ,  A61K51/10 ,  G01N33/574 ,  A61K31/537 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K31/537 ,  A61K38/05 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6867 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/92 ,  G01N33/57492 ,  Y02A50/412 ,  Y02A50/423

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals, including immunoconjugates comprising anti-CD79b cysteine-engineered antibody huMA79b.v28, and to methods of using those compositions of matter for the same.