公开(公告)号：US11261482B2

公开(公告)日：2022-03-01

申请号：US16304340

申请日：2017-05-25

Applicant: GENCURIX INC.

Inventor： Young Kee Shin ,  Bohyun Byun ,  Hyunjeung Choi ,  Joon Seok Choi ,  Young Ho Moon ,  Jong Heun Lee ,  Sang Rea Cho ,  Jee Eun Kim ,  Myungsun Kim

IPC: C12Q1/68 ,  C07H21/04 ,  C12Q1/6827 ,  C12Q1/6823 ,  C12Q1/686 ,  C12Q1/6874 ,  C12Q1/6886

Abstract: The present invention relates to a composition for detecting an epidermal cell growth factor receptor gene mutation and to a kit comprising the composition and, more specifically, to a primer and probe set composition for detecting an epidermal cell growth factor gene mutation, and to a kit for detecting an EGFR gene mutation, comprising the composition. A method according to the present invention can not only predict and diagnose responsiveness to a therapeutic agent for the prognosis of a cancer patient, but also predict a cancer metastasis or relapse Thus, the method can be useful for the purposes of determining the need to administer an anticancer therapeutic agent and guiding the direction of future treatment, and for monitoring a cancer metastasis or relapse.

公开(公告)号：US11970732B2

公开(公告)日：2024-04-30

申请号：US16500549

申请日：2018-04-04

Applicant: GENCURIX INC. ,  LOGONE BIO CONVERGENCE RESEARCH FOUNDATION

Inventor： Young Kee Shin ,  Jin Ju Kim ,  Sung Su Kim ,  Hyun Jeung Choi ,  Young Ho Moon ,  Myung Sun Kim ,  Jee Eun Kim

IPC: C12Q1/68 ,  C12Q1/686

CPC classification number: C12Q1/686

Abstract: The present invention relates to a method for determining the DNA quality of a biological sample and, more specifically, to a method for determining the DNA quality of a biological sample by performing a quantitative polymerase chain reaction (PCR) using primers capable of amplifying a target gene, a method for preparing the primers used in the method, and a method for standardizing the amount of detected target gene mutation by using the determined DNA quality. The method of the present invention enables objective evaluation of the DNA quality of a biological sample used in gene analysis and the presentation of objective results on the expression ratio of a gene mutation, thereby providing reliable information in the fields of clinical research and companion diagnosis.