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公开(公告)号：US09205201B2
公开(公告)日：2015-12-08
申请号：US14178045
申请日：2014-02-11
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
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公开(公告)号：US20180272078A1
公开(公告)日：2018-09-27
申请号：US15730541
申请日：2017-10-11
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality, of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
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公开(公告)号：US09205202B2
公开(公告)日：2015-12-08
申请号：US14178060
申请日：2014-02-11
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
摘要翻译： 流体递送装置包括针阵列，每个针与相应的储存器流体连通。 相应的致动器被联接以便可操作以通过针端口驱动来自储存器的流体。 每个针可以具有多个端口，并且端口可以布置成沿着其长度在任何给定位置处输送基本上相等量的流体。 驱动器联接到致动器以选择性地控制通过针的流体的流速，体积和方向。 该装置可以同时在体内在固体组织中沿相应的轴递送多个流体试剂。 如果之后切除，则可以将组织切片以评估每种药剂对组织的影响，并且基于评估，选择或取消选择用于临床试验或治疗的候选药剂，以及选择或取消选择用于临床试验或治疗性治疗的受试者。
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公开(公告)号：US20140162360A1
公开(公告)日：2014-06-12
申请号：US14178060
申请日：2014-02-11
IPC分类号： A61M5/32
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
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公开(公告)号：US20140309590A1
公开(公告)日：2014-10-16
申请号：US14178022
申请日：2014-02-11
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
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公开(公告)号：US20140162901A1
公开(公告)日：2014-06-12
申请号：US14178045
申请日：2014-02-11
IPC分类号： A61M5/32
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
摘要翻译： 流体递送装置包括针阵列，每个针与相应的储存器流体连通。 相应的致动器被联接以便可操作以通过针端口驱动来自储存器的流体。 每个针可以具有多个端口，并且端口可以布置成沿着其长度在任何给定位置处输送基本上相等量的流体。 驱动器联接到致动器以选择性地控制通过针的流体的流速，体积和方向。 该装置可以同时在体内在固体组织中沿相应的轴递送多个流体试剂。 如果之后切除，则可以将组织切片以评估每种药剂对组织的影响，并且基于评估，选择或取消选择用于临床试验或治疗的候选药剂，以及选择或取消选择用于临床试验或治疗性治疗的受试者。
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