公开(公告)号：US20240200131A1

公开(公告)日：2024-06-20

申请号：US18415344

申请日：2024-01-17

Applicant: Fred Hutchinson Cancer Center

Inventor： Jason H. BIELAS

IPC: C12Q1/6874 ,  C12N15/10 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12Q1/6827 ,  C12Q1/6869 ,  C40B40/08 ,  C40B50/06

CPC classification number: C12Q1/6874 ,  C12N15/10 ,  C12N15/1065 ,  C12N15/1093 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12Q1/6827 ,  C12Q1/6869 ,  C40B40/08 ,  C40B50/06

Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.

公开(公告)号：US20240409996A1

公开(公告)日：2024-12-12

申请号：US18619081

申请日：2024-03-27

Applicant: Fred Hutchinson Cancer Center

Inventor： Jason H. BIELAS

IPC: C12Q1/6874 ,  C12N15/10 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12Q1/6827 ,  C12Q1/6869 ,  C40B40/08 ,  C40B50/06

Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.

公开(公告)号：US20230193381A1

公开(公告)日：2023-06-22

申请号：US17935880

申请日：2022-09-27

Applicant: Fred Hutchinson Cancer Center

Inventor： Jason H. BIELAS

IPC: C12Q1/6874 ,  C12Q1/6869 ,  C12N15/10 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C40B40/08 ,  C40B50/06 ,  C12Q1/6827

CPC classification number: C12Q1/6874 ,  C12Q1/6869 ,  C12N15/1093 ,  C12N15/1065 ,  C12N15/10 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C40B40/08 ,  C40B50/06 ,  C12Q1/6827

Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.

公开(公告)号：US20240401128A1

公开(公告)日：2024-12-05

申请号：US18627305

申请日：2024-04-04

Applicant: Fred Hutchinson Cancer Center

Inventor： Jason H. BIELAS

IPC: C12Q1/6874 ,  C12N15/10 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12Q1/6827 ,  C12Q1/6869 ,  C40B40/08 ,  C40B50/06

Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.

公开(公告)号：US20220349004A1

公开(公告)日：2022-11-03

申请号：US17853716

申请日：2022-06-29

Applicant: Fred Hutchinson Cancer Center

Inventor： Jason H. BIELAS

IPC: C12Q1/6874 ,  C12Q1/6869 ,  C12N15/10 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C40B40/08 ,  C40B50/06 ,  C12Q1/6827

Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.

公开(公告)号：US20240417790A1

公开(公告)日：2024-12-19

申请号：US18620758

申请日：2024-03-28

Applicant: Fred Hutchinson Cancer Center

Inventor： Jason H. BIELAS

IPC: C12Q1/6874 ,  C12N15/10 ,  C12N15/70 ,  C12N15/81 ,  C12N15/85 ,  C12Q1/6827 ,  C12Q1/6869 ,  C40B40/08 ,  C40B50/06

Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.