公开(公告)号：US20070179105A1

公开(公告)日：2007-08-02

申请号：US11343694

申请日：2006-01-31

申请人： Essam Awdalla

发明人： Essam Awdalla

IPC分类号： A61K48/00 ,  A61K38/17 ,  A61K51/00 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/4745 ,  A61K31/57 ,  A61K31/366

CPC分类号： A61K31/4745 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/727 ,  A61K48/00

摘要： The present invention relates to method and means for treating a vascularized solid tumor using a number of, in vitro prepared, anticellular agent(s)-carrying blood platelets to induce a thrombus formation within the tumor vasculature, and at the same time to deliver a high concentration of an anticellular agent within the tumor. The blood platelets are targeted and attached to the tumor vasculature using in vivo assembled binding complexes, each having at least one binding site specifically binding to tumor cells or to tumor-associated vasculature, and at least one binding site specifically binding to a blood platelet surface. The platelet-mediated thrombus formed within the tumor vasculature leads to occlusion of the tumor vasculature, with ultimate destruction of the centrally located tumor cells. This is followed by destruction or suppressing the growth or cell division of the peripherally located tumor cells, by the anticellular agent(s) carried by the blood platelets.

摘要翻译： 本发明涉及使用许多体外制备的抗细胞剂（血液血小板）来诱导血管内血栓形成的血管化实体瘤的方法和手段，并且同时递送 高浓度的抗细胞剂在肿瘤内。 使用体内装配的结合复合物将血小板靶向并连接到肿瘤脉管系统，每个结合复合物具有至少一个特异性结合肿瘤细胞的结合位点或与肿瘤相关的脉管系统结合，以及至少一个特异性结合血小板表面的结合位点 。 在肿瘤脉管系统内形成的血小板介导的血栓导致肿瘤脉管系统闭塞，最终破坏位于中心的肿瘤细胞。 其次是由血小板携带的抗细胞剂破坏或抑制周边定位的肿瘤细胞的生长或细胞分裂。

公开(公告)号：US20050249591A1

公开(公告)日：2005-11-10

申请号：US11181078

申请日：2005-07-14

申请人： Essam Awdalla

发明人： Essam Awdalla

IPC分类号： F03C2/00 ,  F04D17/02 ,  F04D17/16 ,  F04D29/54

CPC分类号： F01D1/06 ,  F04D17/02 ,  F04D17/168

摘要： A rotary ram-out vacuum pump, used for decreasing the pressure of a gas within a space ahead of the vacuum pump, comprising: a stationary casing having at least one inlet passage communicating with the space ahead of the vacuum pump, and at least one exit passage freely communicating with surrounding atmospheric air; a drive shaft supported for rotation inside the casing; and a rotor assembly housed inside the casing and including a plurality of sweeping channels. In operation, gas is rammed out, through the sweeping channels of the vacuum pump, from the space ahead of the vacuum pump to surrounding atmospheric air, and thus decreasing the density and pressure of the gas in the space ahead of the vacuum pump.

摘要翻译： 一种旋转拉出式真空泵，用于降低真空泵前方空间内的气体压力，包括：具有至少一个与真空泵前方空间连通的入口通道的固定壳体，以及至少一个 出口通道与周围大气自由通气; 驱动轴，其被支撑以在壳体内旋转; 以及容纳在壳体内并包括多个扫掠通道的转子组件。 在操作中，气体通过真空泵的清扫通道从真空泵前面的空间被冲击到周围的大气中，从而降低真空泵前方空气中的密度和压力。

公开(公告)号：US20070178104A1

公开(公告)日：2007-08-02

申请号：US11399281

申请日：2006-04-06

申请人： Essam Awdalla

发明人： Essam Awdalla

IPC分类号： A61K51/00 ,  A61K39/395 ,  A61K31/7048 ,  A61K31/704 ,  A61K31/4745 ,  A61K48/00 ,  A61K31/727

CPC分类号： A61K31/366 ,  A61K31/4745 ,  A61K31/57 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/727 ,  A61K48/00

摘要： The present invention relates to method and means for treating a vascularized solid tumor using a number of, in vitro prepared, anticellular agent(s)-carrying blood platelets to induce a thrombus formation within the tumor vasculature, and at the same time to deliver a high concentration of an anticellular agent within the tumor. The blood platelets are targeted and attached to the tumor vasculature using in vivo assembled binding complexes, each having at least one binding site specifically binding to tumor cells or to tumor-associated vasculature, and at least one binding site specifically binding to a blood platelet surface. The platelet-mediated thrombus formed within the tumor vasculature leads to occlusion of the tumor vasculature, with ultimate destruction of the centrally located tumor cells. This is followed by destruction or suppressing the growth or cell division of the peripherally located tumor cells, by the anticellular agent(s) carried by the blood platelets.

摘要翻译： 本发明涉及使用许多体外制备的抗细胞剂（血液血小板）来诱导血管内血栓形成的血管化实体瘤的方法和手段，并且同时递送 高浓度的抗细胞剂在肿瘤内。 使用体内装配的结合复合物将血小板靶向并连接到肿瘤脉管系统，每个结合复合物具有至少一个特异性结合肿瘤细胞的结合位点或与肿瘤相关的脉管系统结合，以及至少一个特异性结合血小板表面的结合位点 。 在肿瘤脉管系统内形成的血小板介导的血栓导致肿瘤脉管系统闭塞，最终破坏位于中心的肿瘤细胞。 其次是由血小板携带的抗细胞剂破坏或抑制周边定位的肿瘤细胞的生长或细胞分裂。

公开(公告)号：US20070065278A1

公开(公告)日：2007-03-22

申请号：US11070914

申请日：2005-03-03

申请人： Essam Awdalla

发明人： Essam Awdalla

IPC分类号： F04D29/44

CPC分类号： F04D29/44 ,  F04D29/54

摘要： A radial out-flowing rotary ram-in compressor for use in gas turbine engines and the like, having a plurality of vanes attached to discs, with the opposing parts of each two adjacent vanes defining a feeding channel in-between. In operation, working gases are rammed through the feeding channels in a generally radially outward direction, followed by positive displacement of the rammed-in gases to a receiver wherein pressurized gases collect. The pressurized gases are actively swept from the receiver by either a successive rotary ram-in compressor or a successive rotary ram compressor.

摘要翻译： 用于燃气涡轮发动机等的径向流出的旋转冲压压缩机，其具有附接到盘的多个叶片，每个两个相邻叶片的相对部分在其间限定进给通道。 在操作中，工作气体在大致径向向外的方向上通过进料通道撞击，随后将压入气体正向移动到加压气体收集器的接收器中。 压缩气体通过连续的旋转压入式压缩机或连续的旋转柱塞压缩机被主动地从接收器扫过。

公开(公告)号：US20050061000A1

公开(公告)日：2005-03-24

申请号：US10669279

申请日：2003-09-23

申请人： Essam Awdalla

发明人： Essam Awdalla

IPC分类号： F02B37/18 ,  F02B37/24 ,  F02C3/00 ,  F02C3/36 ,  F02C9/16 ,  F02C9/22 ,  F02B33/44

CPC分类号： F02C9/22 ,  F02B37/18 ,  F02B37/24 ,  F02C3/00 ,  F02C3/36 ,  F02C9/16

摘要： The present invention provides a supercharged open cycle gas turbine engine comprising a core engine for generating shaft power output, said core engine includes a multi-stage compressor, the first stage of which being a rotary ram compressor or a rotary ram-in compressor; a supercharger for increasing the pressure of intake air of the core engine, said supercharger includes a rotary ram-in compressor and a turbine driven by gases discharged from the core engine and having variable-area nozzle assembly; operator controlled means for elective bleeding of variable part of the exhaust gases discharged from the core engine and supplied to the supercharger turbine; at least one pressure sensor for detecting the degree of rise in the pressure of air supplied by the supercharger's compressor; means for adjusting the area of the nozzles of the supercharger's turbine according to the detected degree of rise in the air pressure; and means for adjusting the rate of fuel supply to the core engine according to the pressure level of air supplied by the supercharger's compressor.

摘要翻译： 本发明提供一种增压开式循环燃气涡轮发动机，其包括用于产生轴功率输出的核心发动机，所述核心发动机包括多级压缩机，其第一级为旋转式压缩机压缩机或旋转式压入式压缩机; 用于增加核心发动机的进气压力的增压器，所述增压器包括旋转压入式压缩机和由从核心发动机排出的气体驱动并具有可变面积喷嘴组件的涡轮机; 操作者控制装置，用于从核心发动机排出并供应给增压器涡轮机的可变部分废气的选通; 至少一个压力传感器，用于检测由增压器的压缩机供给的空气的压力上升的程度; 用于根据检测到的空气压力升高来调节增压器的涡轮的喷嘴的面积的装置; 以及用于根据由增压器的压缩机供给的空气的压力水平来调节到核心发动机的燃料供给速率的装置。

公开(公告)号：US20060225432A1

公开(公告)日：2006-10-12

申请号：US11092408

申请日：2005-03-29

申请人： Essam Awdalla

发明人： Essam Awdalla

IPC分类号： F02C3/04

CPC分类号： F02C6/12 ,  F02C3/04 ,  F05D2220/74

摘要： The present invention provides a supercharged open cycle gas turbine engine comprising a core engine for generating shaft power output; a supercharger for increasing the density and pressure of intake air of the core engine, said supercharger includes a rotary ram-in compressor; a receiver; and a turbine having variable-area nozzle assembly; at least one conduit for communicating the supercharger's receiver with its surrounding atmospheric air, said conduit being provided with a valve for controlling the flow of air through it; at least one pressure sensor for detecting the degree of rise in the pressure of air supplied by the supercharger's compressor; means for adjusting the area of the nozzles of the supercharger's turbine according to the detected degree of rise in the air pressure; and means for adjusting the rate of fuel supply to the core engine according to the pressure level of air supplied by the supercharger's compressor.

摘要翻译： 本发明提供了一种增压开式循环燃气涡轮发动机，其包括用于产生轴功率输出的核心发动机; 增压器，其用于增加所述核心发动机的进气的密度和压力，所述增压器包括旋转压入式压缩机; 接收器 和具有可变面积喷嘴组件的涡轮机; 至少一个导管，用于使增压器的接收器与其周围的大气连通，所述导管设置有用于控制通过其的空气流动的阀; 至少一个压力传感器，用于检测由增压器的压缩机供给的空气的压力上升的程度; 用于根据检测到的空气压力升高来调节增压器的涡轮的喷嘴的面积的装置; 以及用于根据由增压器的压缩机供给的空气的压力水平来调节向核心发动机供油的速率的装置。

公开(公告)号：US20050250114A1

公开(公告)日：2005-11-10

申请号：US10841746

申请日：2004-05-07

申请人： Essam Awdalla

发明人： Essam Awdalla

IPC分类号： A01N37/10 ,  A61K31/19 ,  A61K38/21 ,  A61K38/48 ,  C12N7/00 ,  C12N7/01 ,  C12Q1/68

CPC分类号： A61K31/19 ,  A61K38/212 ,  A61K38/4886

摘要： The present invention provides a method for decreasing the number of free virus particles within the bodily fluids of a mammal infected by a virus, comprising the steps of: a) specifying the type of the pathogenic virus; b) providing a supply of host cells susceptible to the specified virus type; c) treating the host cells provided in step (b) with one, or more than one viral replication inhibiting means; d) washing the host cells prepared in step (c) with a sterile physiological medium; and e) administering the host cells prepared in step (d) to the mammal. The host cells are administered to the mammal either by intravenous injection, injection into the CSF, or spraying within its respiratory tract passages.

摘要翻译： 本发明提供了一种减少受病毒感染的哺乳动物的体液中的游离病毒颗粒数量的方法，包括以下步骤：a）确定病原病毒的类型; b）提供对特定病毒类型易感的宿主细胞供应; c）用一种或多于一种病毒复制抑制手段处理步骤（b）中提供的宿主细胞; d）用无菌生理培养基洗涤步骤（c）中制备的宿主细胞; 和e）将步骤（d）中制备的宿主细胞给予哺乳动物。 宿主细胞通过静脉注射，注射到CSF中或在其呼吸道通道内喷洒而施用于哺乳动物。

公开(公告)号：US20050227351A1

公开(公告)日：2005-10-13

申请号：US10820569

申请日：2004-04-08

申请人： Essam Awdalla

发明人： Essam Awdalla

IPC分类号： A61K39/395 ,  A61K39/40 ,  A61K39/42 ,  C07K16/00 ,  C07K16/08 ,  C12N5/06 ,  C12N5/16 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/53

CPC分类号： C07K16/00 ,  C07K16/08 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2319/00

摘要： The present invention provides compound protein molecules for inducing cytotoxic cell-mediated immune response in a mammal against a pathogenic cell displaying an antigen on its outer surface. In a preferred embodiment, the compound protein molecule comprises in sequence: a foreign class I MHC molecule; a linking (Fab) antibody fragment; an alpha-helix shaped chain linker; and a (Fab) fragment of an antibody specific against the antigen displayed by the pathogenic cell. In another preferred embodiment, the compound protein molecule comprises in sequence: a foreign class I MHC molecule; a linking (Fab) antibody fragment; an alpha-helix shaped chain linker; a (Fab′2) fragment of an antibody specific against the antigen displayed by the pathogenic cell; an alpha-helix shaped chain linker; a linking (Fab) antibody fragment; and a foreign class I MHC molecule. Methods for inducing an immune response using these compound protein molecules are also disclosed.

摘要翻译： 本发明提供用于在哺乳动物中诱导细胞毒性细胞介导的免疫应答的化合物蛋白质分子，其针对在其外表面上显示抗原的致病细胞。 在优选的实施方案中，所述化合物蛋白质分子依次包含外来I类MHC分子; 连接（Fab）抗体片段; α螺旋形链接体; 和针对由致病细胞显示的抗原特异的抗体的（Fab）片段。 在另一个优选的实施方案中，化合物蛋白质分子依次包含：外来I类MHC分子; 连接（Fab）抗体片段; α螺旋形链接体; 对由病原体显示的抗原特异的抗体的（Fab'2）片段; α螺旋形链接体; 连接（Fab）抗体片段; 和外来I类MHC分子。 还公开了使用这些化合物蛋白质分子诱导免疫应答的方法。

公开(公告)号：US20050063820A1

公开(公告)日：2005-03-24

申请号：US10669514

申请日：2003-09-23

申请人： Essam Awdalla

发明人： Essam Awdalla

IPC分类号： F01D1/02 ,  F01D1/06

CPC分类号： F01D1/06

摘要： A rotary ram-in compressor for use in gas turbine engines and the like, having a plurality of vanes attached to discs, with the opposing parts of each two adjacent vanes defining a feeding channel in-between. In operation, working gases are rammed through the feeding channels, followed by positive displacement of the rammed-in gases to a receiver wherein pressurized gases collect. The pressurized gases are actively swept from the receiver by either a successive rotary ram-in compressor or a successive rotary ram compressor.

摘要翻译： 一种用于燃气涡轮发动机等的旋转式压入式压缩机，其具有附接到盘的多个叶片，每个两个相邻叶片的相对部分在其间限定进料通道。 在操作中，工作气体通过进料通道被撞击，随后将压入气体正向移动到加压气体收集器的接收器中。 压缩气体通过连续的旋转压入式压缩机或连续的旋转柱塞压缩机被主动地从接收器扫过。

公开(公告)号：US20060198730A1

公开(公告)日：2006-09-07

申请号：US11069267

申请日：2005-03-01

申请人： Essam Awdalla

发明人： Essam Awdalla

IPC分类号： F04D29/44

CPC分类号： F04D17/02 ,  F04D29/282

摘要： A rotary ram compressor for use in gas turbine engines and the like, having a plurality of vanes attached to discs, with the opposing parts of each two adjacent vanes and the opposing parts of the disks' surfaces confined between the opposing parts of the surfaces of the two adjacent vanes defining a channel in-between. Each channel is formed of two successive freely communicating portions: a first diverging inlet portion; and a second constant cross-sectional area outlet portion. In operation, gases are rammed into the first diverging inlet portion of the channel and are gradually displaced to the second constant cross-sectional area outlet portion of the channel, while being diverged, resulting into a rise in the static pressure energy of the gases, followed by smoothening of the stream of flow of the pressurized gases within the second constant cross-sectional area outlet portion of the channel.

摘要翻译： 一种用于燃气涡轮发动机等的旋转柱塞压缩机，其具有附接到盘的多个叶片，每个两个相邻叶片的相对部分和盘表面的相对部分限定在相对的表面的相对部分之间 两个相邻的叶片在其间限定通道。 每个通道由两个连续的自由连通部分形成：第一发散入口部分; 和第二恒定横截面积出口部分。 在操作中，气体被撞到通道的第一发散入口部分中，并且逐渐地移动到通道的第二恒定横截面区域出口部分，同时发散，导致气体的静态压力能量的上升， 随后在通道的第二恒定横截面区域出口部分内的加压气体流的平滑化。