公开(公告)号：US08460208B2

公开(公告)日：2013-06-11

申请号：US13357127

申请日：2012-01-24

申请人： Eric Peltier

发明人： Eric Peltier

IPC分类号： A61B10/00 ,  B01D24/00 ,  B01D35/24 ,  B01D24/38 ,  C12M1/34

CPC分类号： A61B10/0096 ,  A61B2010/0216

摘要： A system for preparing a cytological suspension is based on a fixing solution. The system containing a cytological sample-taking brush and a flask having an opening for receiving the cytological sample-taking brush are detachably fastened to a handle including a brush-receiving filter basket that is at least partially immersed in the a suspension.

摘要翻译： 用于制备细胞学悬浮液的系统基于定影液。 包含细胞学取样刷和具有用于接收细胞学取样刷的开口的烧瓶的系统可拆卸地紧固到包括至少部分浸没在悬浮液中的刷接收过滤篮的手柄。

公开(公告)号：US20100178689A1

公开(公告)日：2010-07-15

申请号：US12663095

申请日：2008-06-02

申请人： Eric Peltier

发明人： Eric Peltier

IPC分类号： C12M1/00

CPC分类号： G01N1/2813 ,  G01N2001/2826 ,  G01N2001/2846

摘要： A device includes a reception chamber (5) for a cell suspension having an open bottom (6) extending opposite a cell deposition area (7) of the analysis plate (1), the bottom (6) of the chamber (5) being in fluid communication with an absorption material (14) for cell preservation liquid for absorbing the latter and enabling a homogeneous decantation deposition on the deposition area (7), the absorption material (14) being provided about the cell deposition area (7). The absorption material (14) includes a compressed area (16) extending between the bottom (6) of the reception chamber (5) and the analysis plate (1) about the cell deposition area (7), and a non-compressed area (17) extending about the compressed area (16).

摘要翻译： 一种装置包括用于细胞悬浮液的接收室（5），其具有与分析板（1）的细胞沉积区域（7）相对延伸的开放底部（6），腔室（5）的底部（6）处于 与用于吸收后者的细胞保存液体的吸收材料（14）流体连通并且能够在沉积区域（7）上进行均匀倾析沉积，所述吸收材料（14）围绕电池沉积区域（7）设置。 吸收材料（14）包括在接收室（5）的底部（6）与围绕电池沉积区域（7）的分析板（1）之间延伸的压缩区域（16）和非压缩区域 17）围绕压缩区域（16）延伸。

公开(公告)号：US20090326414A1

公开(公告)日：2009-12-31

申请号：US12374841

申请日：2007-07-04

申请人： Eric Peltier

发明人： Eric Peltier

IPC分类号： A61B10/02

CPC分类号： A61B10/02 ,  A61B10/0291 ,  A61B2010/0074 ,  A61B2010/0216

摘要： A cytological sampling brush includes a manipulation handle (2) at one of end of which are provided a first portion in the form of exocol sampling brush (4) and a second portion in the form of endocol sampling swab (5) at the center of the first portion in brush (4) form. This brush is characterized in that the second portion in swab (5) form is attached at the end of the handle (2) and is removable from the first portion by sliding in a hole (6) of the first portion in brush (4) form, provided with elements (7) for retaining cells for collecting cells from the second portion in swab (5) form, during retraction of the first portion in brush (4) form.

摘要翻译： 细胞学取样刷包括一个操作把手（2），其操作手柄（2）的一端处设置有exocol取样刷（4）形式的第一部分，并且以endocol取样拭子（5）形式的第二部分位于 刷（4）中的第一部分形成。 这种刷子的特征在于，拭子（5）形式的第二部分附接在手柄（2）的端部，并且通过在刷子（4）中的第一部分的孔（6）中滑动而从第一部分移除， 形式，在第一部分在刷子（4）形式的缩回期间设置有用于保持用于从拭子（5）形式的第二部分收集细胞的细胞的元件（7）。

公开(公告)号：US08478018B2

公开(公告)日：2013-07-02

申请号：US12995089

申请日：2009-05-29

申请人： Eric Peltier

发明人： Eric Peltier

IPC分类号： G06K9/00 ,  C12N5/00 ,  G01N33/554

CPC分类号： G06T7/0012 ,  G02B21/365 ,  G06K9/00127 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30024

摘要： A method includes carrying out at least a first processing of a sample (2), the processing being adapted to mark pathological cells among the sample cells; and carrying out several image acquisitions of the sample (2) provided on an analysis plate (6) in order to obtain images each representing an area of the analysis plate (6) wherein the images set side by side define an image (20) of the entire sample. The method further includes automatically running all the acquired images of the sample (2) on a display at a predetermined running speed, the speed being adapted for enabling an observer to analyze the image and to determine if the represented sample area includes potentially pathological cells or not; and stopping the running if at least one abnormality is detected that may indicate the presence of a pathological cell.

摘要翻译： 一种方法包括进行样品（2）的至少第一处理，所述处理适于标记样品池中的病理细胞; 并对分析板（6）上提供的样品（2）进行几次图像采集，以获得各自表示分析板（6）的区域的图像，其中并排设置的图像限定图像（20）， 整个样品。 该方法还包括以预定的运行速度在显示器上自动地运行样品（2）的所有获取的图像，该速度适于使得观察者能够分析图像并且确定所示出的样本区域是否包括潜在的病理细胞或 不; 并且如果检测到至少一个可能指示存在病理细胞的异常，则停止运行。

公开(公告)号：US20130059330A1

公开(公告)日：2013-03-07

申请号：US13575325

申请日：2011-01-20

申请人： Eric Peltier

发明人： Eric Peltier

IPC分类号： G01N1/30

CPC分类号： A01N1/02 ,  A01N1/0231 ,  G01N1/30

摘要： This fixing solution is intended to preserve in vitro a cytological sample, comprising nucleated cells and erythrocytes and comprises alcohol for fixing the cells. It comprises physiological saline in order to avoid osmotic shocks at the wall of the cells, formalin and polyethylene glycol for retaining the size and the integrity of the nucleated cells and erythrocytes, which are fixed in said solution.The solution does not contain acetone or any compounds of the ketone or acetic acid family.

摘要翻译： 该固定溶液旨在在体外保留包含有核细胞和红细胞的细胞学样品，并且包含用于固定细胞的醇。 它包括生理盐水，以避免在细胞壁上的渗透冲击，福尔马林和聚乙二醇，用于保持固定在所述溶液中的有核细胞和红细胞的大小和完整性。 该溶液不含有丙酮或酮或乙酸族的任何化合物。

公开(公告)号：US20110262907A1

公开(公告)日：2011-10-27

申请号：US13126650

申请日：2009-10-28

申请人： Eric Peltier

发明人： Eric Peltier

IPC分类号： C12Q1/68 ,  C12Q1/02

CPC分类号： G02B21/367 ,  G01N1/30 ,  G01N33/569

摘要： This method includes the following steps: carrying out a processing of the specimen so as to make it possible to differentiate the pathological cells from the healthy cells of the specimen; and performing an acquisition of images of the specimen disposed on an analysis plate so as to obtain a plurality of images each representing a zone of the analysis plate, the images placed side by side forming an image of the whole of the specimen so as to create a virtual analysis plate. The method furthermore includes the following step: performing on the virtual analysis plate a processing of the images acquired so as to obtain a virtual restitution of the colors and of the intensity of the colors of the cytoplasm and/or of the nucleus, the colors and the intensity being able to be modified according to the preferences of the person in charge of the analysis.

摘要翻译： 该方法包括以下步骤：进行样本的处理，以使病理细胞与样本的健康细胞分化; 并且执行对设置在分析板上的样本的图像的获取，以便获得各自表示分析板的区域的多个图像，并排地形成形成整个样本的图像的图像，以便产生 一个虚拟分析板。 该方法还包括以下步骤：在虚拟分析板上执行所获取的图像的处理，以便获得颜色和细胞质和/或核的颜色的强度的虚拟恢复，颜色和 强度可以根据分析负责人的偏好进行修改。

公开(公告)号：US20100089925A1

公开(公告)日：2010-04-15

申请号：US12527254

申请日：2008-02-13

申请人： Eric Peltier

发明人： Eric Peltier

IPC分类号： B65D41/04 ,  A47F7/00

CPC分类号： B01L9/06 ,  B01L3/5082 ,  G01N35/026

摘要： A tray for carrying at least one bottle that has to be positioned and held precisely on the tray, includes a support on which the bottle is intended to be placed, at least two rails running substantially parallel to one another along the support, the rails including at least one shoulder extending above the support toward the other rail so that a lower edge of the bottle can fit between and be immobilized in the rails in a longitudinal or transverse direction and in an upwards direction, each rail having at least one imprint, the imprints being positioned facing one another, each imprint being designed to accommodate an immobilizing element provided on the bottle so that the bottle can be immobilized in the rails in a longitudinal or transverse direction. A bottle used with a tray such as this is also described.

摘要翻译： 用于承载至少一个必须定位并且精确地保持在托盘上的瓶子的托盘包括一个支撑件，瓶子要被放置在该支架上，至少两个轨道沿支撑件彼此基本平行地延伸，轨道包括 至少一个肩部，其延伸到支撑件上方朝向另一个导轨，使得瓶子的下边缘可以在纵向或横向方向上并且沿向上的方向装配在轨道中并且被固定在轨道中，每个轨道具有至少一个压印， 印记被定位成彼此面对，每个印记被设计成容纳设置在瓶子上的固定元件，使得瓶子可以沿纵向或横向固定在轨道中。 还描述了与这样的托盘一起使用的瓶子。

公开(公告)号：US06346087B1

公开(公告)日：2002-02-12

申请号：US09550098

申请日：2000-04-14

申请人： Eric Peltier

发明人： Eric Peltier

IPC分类号： A61B1001

CPC分类号： A61B10/0291 ,  A61B10/0096 ,  A61B2010/0216

摘要： This flask for preparing a fixative-based cytological suspension, which flask is provided with an opening (5) which is intended for receiving a brush (3) for cytological sampling, which brush is detachably fastened to a manipulation handle (4), is such that the opening (5) of the flask comprises abutment means (6) for the brush, which means enable the brush to be locked in the flask and to be detached from the handle (4), and at least one portion of perforated screen (6) for filtering the suspension during pouring.

摘要翻译： 该烧瓶用于制备基于固定剂的细胞学悬浮液，该烧瓶设置有用于接收用于细胞学取样的刷子（3）的开口（5），该刷子可拆卸地紧固到操纵手柄（4），这样 烧瓶的开口（5）包括用于刷子的抵靠装置（6），这意味着刷子被锁定在烧瓶中并与手柄（4）分离，并且穿孔筛网的至少一部分 6）用于在浇注过程中过滤悬浮液。

公开(公告)号：US09983222B2

公开(公告)日：2018-05-29

申请号：US13636665

申请日：2011-03-21

申请人： Eric Peltier

发明人： Eric Peltier

IPC分类号： C12Q1/02 ,  C12Q1/24 ,  G01N35/10 ,  G01N1/31 ,  G01N1/28

CPC分类号： G01N35/10 ,  G01N1/312 ,  G01N2001/2846 ,  G01N2035/106

摘要： The present invention relates to a process for preparing and analyzing a plurality of cell suspensions (5) comprising at least the following successive steps: (a) loading a plurality of bottles (4) onto a reception plate (6), each bottle (4) comprising a cell suspension (5) to be analyzed; (b) loading a plurality of analysis containers (32, 34, 36) onto the reception plate (6); and (c) taking a sample of a cell suspension (5) from a bottle (4) and depositing this sample in an analysis container (34, 36); wherein step (c) is repeated for each bottle (4) to be analyzed. Step (c) of taking a sample of a cell suspension from a bottle (4) and depositing this sample in an analysis container (34, 36) comprises at least one step of breaking up the cell clusters by virtue of pipetting distribution means (20).The invention also relates to an automated device for implementing this process.

公开(公告)号：US20130034874A1

公开(公告)日：2013-02-07

申请号：US13636665

申请日：2011-03-21

申请人： Eric Peltier

发明人： Eric Peltier

IPC分类号： C12Q1/02 ,  C12M1/34

CPC分类号： G01N35/10 ,  G01N1/312 ,  G01N2001/2846 ,  G01N2035/106

摘要： The present invention relates to a process for preparing and analysing a plurality of cell suspensions (5) comprising at least the following successive steps: (a) loading a plurality of bottles (4) onto a reception plate (6), each bottle (4) comprising a cell suspension (5) to be analysed; (b) loading a plurality of analysis containers (32, 34, 36) onto the reception plate (6); and (c) taking a sample of a cell suspension (5) from a bottle (4) and depositing this sample in an analysis container (34, 36); wherein step (c) is repeated for each bottle (4) to be analysed. Step (c) of taking a sample of a cell suspension from a bottle (4) and depositing this sample in an analysis container (34, 36) comprises at least one step of breaking up the cell clusters by virtue of pipetting distribution means (20).The invention also relates to an automated device for implementing this process.

摘要翻译： 本发明涉及一种制备和分析多个细胞悬浮液（5）的方法，所述多个细胞悬浮液（5）至少包括以下连续步骤：（a）将多个瓶子（4）装载到接收板（6）上，每个瓶子 ）包括待分析的细胞悬浮液（5） （b）将多个分析容器（32,34,36）装载到接收板（6）上; 和（c）从瓶（4）中取出细胞悬浮液（5）的样品，并将该样品沉积在分析容器（34,36）中; 其中对于要分析的每个瓶（4）重复步骤（c）。 从瓶（4）中取出细胞悬浮液样品并将该样品沉积在分析容器（34,36）中的步骤（c）包括至少一个步骤，借助于移液分配装置（20 ）。 本发明还涉及一种用于实现该过程的自动化装置。