公开(公告)号：US12117438B2

公开(公告)日：2024-10-15

申请号：US16936121

申请日：2020-07-22

Applicant: Element Biosciences, Inc.

Inventor： Sinan Arslan ,  Molly He ,  Matthew Kellinger ,  Jake Levieux ,  Michael Previte ,  Junhua Zhao ,  Su Zhang

IPC: G01N33/53 ,  C12Q1/6874 ,  G01N33/58

CPC classification number: G01N33/5308 ,  C12Q1/6874 ,  G01N33/582

Abstract: Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.

公开(公告)号：US10768173B1

公开(公告)日：2020-09-08

申请号：US16579794

申请日：2019-09-23

Applicant: Element Biosciences, Inc.

Inventor： Sinan Arslan ,  Molly He ,  Matthew Kellinger ,  Jake Levieux ,  Michael Previte ,  Junhua Zhao ,  Su Zhang

IPC: C12Q1/6869 ,  C07H21/00 ,  G01N33/53 ,  G01N33/58 ,  C12Q1/6874

Abstract: Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.