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1.发明授权公开(公告)号：US11654112B2
公开(公告)日：2023-05-23
申请号：US16463238
申请日：2017-11-22
Applicant: Elektrofi, Inc.
Inventor： Chase Coffman , Lyndon Charles , Paul Brown , Daniel Benjamin Dadon , Lisa Liu , Cory Robinson
IPC: A61K9/16 , A61K39/395 , A61K9/50 , B05B5/025
CPC classification number: A61K9/1682 , A61K9/5089 , A61K39/395 , B05B5/025
Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.
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公开(公告)号：US20210322317A1
公开(公告)日：2021-10-21
申请号：US17364770
申请日：2021-06-30
Applicant: Elektrofi, Inc.
Inventor： Chase Spenser Coffman , Lyndon Fitzgerald Charles, JR. , Paul Brown , Daniel Benjamin Dadon , Lisa Liu , Cory Robinson , Dale Arlington Thomas, III
Abstract: The invention provides methods for the preparation of particles including one or more agents, e.g., therapeutic or diagnostic agents. The particles can be formed by creating droplets of a first liquid, e.g., including an agent, and removing the first liquid, e.g., through its dispersal in a second liquid and/or evaporation, to solidify the droplets. Advantageously, the process of forming the particles does not significantly alter the structure or activity of the agents and may enhance the stability of the agents. For example, the particles may be stored for long periods of time without significant loss of activity, and in some embodiments, without the need for refrigeration. These particles may be used to generate stabilized pharmaceutical compositions for storage or other logistical purposes, pharmaceutical suspensions, pharmaceutical powder formulations (e.g., inhalable powders, injectable powders), creams or other topical pastes, nutraceuticals, or cosmetics.
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公开(公告)号：US20250025425A1
公开(公告)日：2025-01-23
申请号：US18907018
申请日：2024-10-04
Applicant: Elektrofi, Inc.
Inventor： Paul Brown , Lyndon Fitzgerald Charles, JR. , Chase Spenser Coffman , Daniel Benjamin Dadon , James Ivey , Lisa Liu , Chaitanya Sudrik
Abstract: The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.
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公开(公告)号：US11717488B2
公开(公告)日：2023-08-08
申请号：US17351937
申请日：2021-06-18
Applicant: Elektrofi, Inc.
Inventor： Paul Brown , Lyndon Fitzgerald Charles, Jr. , Chase Spenser Coffman , Daniel Benjamin Dadon , James Ivey , Lisa Liu , Chaitanya Sudrik
Abstract: The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.
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5.发明申请公开(公告)号：US20220389084A1
公开(公告)日：2022-12-08
申请号：US17883427
申请日：2022-08-08
Applicant: Elektrofi, Inc.
Inventor： Paul Brown , Tyler L. Carter , Lyndon Fitzgerald Charles, JR. , Chase Spenser Coffman , Daniel Benjamin Dadon , Lisa Liu , Sadiqua Shadbar , Chaitanya Sudrik , Yi Tang , Shankul Vartak
Abstract: The present disclosure provides compositions and methods for treating a disease or condition in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of a composition comprising a plurality of particles comprising at least one therapeutic biologic suspended in a pharmaceutically acceptable liquid carrier.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20240415782A1
公开(公告)日：2024-12-19
申请号：US18816200
申请日：2024-08-27
Applicant: Elektrofi, Inc.
Inventor： Chase Spenser Coffman , Lyndon Fitzgerald Charles, Jr. , Paul Brown , Daniel Benjamin Dadon , Lisa Liu , Sadiqua Shadbar , Chaitanya Sudrik
Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.
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公开(公告)号：US20240293332A1
公开(公告)日：2024-09-05
申请号：US18659740
申请日：2024-05-09
Applicant: Elektrofi, Inc.
Inventor： Paul Brown , Lyndon Fitzgerald Charles, JR. , Chase Spenser Coffman , Daniel Benjamin Dadon , James W. Ivey , Lisa Liu , Chaitanya Sudrik
Abstract: The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.
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公开(公告)号：US20210315827A1
公开(公告)日：2021-10-14
申请号：US17351937
申请日：2021-06-18
Applicant: Elektrofi, Inc.
Inventor： Paul Brown , Lyndon Fitzgerald Charles, JR. , Chase Spenser Coffman , Daniel Benjamin Dadon , James Ivey , Lisa Liu , Chaitanya Sudrik
Abstract: The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.
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公开(公告)号：US11077059B2
公开(公告)日：2021-08-03
申请号：US16633097
申请日：2018-07-25
Applicant: Elektrofi, Inc.
Inventor： Chase Spenser Coffman , Lyndon Fitzgerald Charles, Jr. , Paul Brown , Daniel Benjamin Dadon , Lisa Liu , Cory Robinson , Dale Arlington Thomas, III
Abstract: The invention provides methods for the preparation of particles including one or more agents, e.g., therapeutic or diagnostic agents. The particles can be formed by creating droplets of a first liquid, e.g., including an agent, and removing the first liquid, e.g., through its dispersal in a second liquid and/or evaporation, to solidify the droplets. Advantageously, the process of forming the particles does not significantly alter the structure or activity of the agents and may enhance the stability of the agents. For example, the particles may be stored for long periods of time without significant loss of activity, and in some embodiments, without the need for refrigeration. These particles may be used to generate stabilized pharmaceutical compositions for storage or other logistical purposes, pharmaceutical suspensions, pharmaceutical powder formulations (e.g., inhalable powders, injectable powders), creams or other topical pastes, nutraceuticals, or cosmetics.
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10.发明申请公开(公告)号：US20250064744A1
公开(公告)日：2025-02-27
申请号：US18946268
申请日：2024-11-13
Applicant: Elektrofi, Inc
Inventor： Chase Spenser Coffman , Lyndon Fitzgerald Charles, JR. , Paul Brown , Daniel Benjamin Dadon , Lisa Liu , Cory Robinson
IPC: A61K9/16 , A61K9/50 , A61K39/395 , B05B5/025
Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.
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