公开(公告)号：US20180296603A1

公开(公告)日：2018-10-18

申请号：US15579633

申请日：2016-06-09

Applicant: EDITAS MEDICINE, INC.

Inventor： Jennifer Leah Gori ,  Tongyao Wang ,  Hariharan Jayaram ,  Penrose ODonnell

IPC: A61K35/28 ,  C12N5/0789 ,  C07K14/74 ,  C12N15/11 ,  C12N9/22 ,  C12N15/86 ,  G06F19/28 ,  G06F19/24

Abstract: Disclosed herein are compositions and methods for increasing the immunocompatibility of donor cells (e.g., HSCs or T-cells) for transplantation to a recipient subject, as well as database schemes for use in the methods. The methods and compositions described herein result in the allele-specific modification of one or more immunogenicity genes (e.g., an HLA gene) of a cell, resulting in cells that are suitable for transplantation into a recipient subject.

公开(公告)号：US12031132B2

公开(公告)日：2024-07-09

申请号：US17019154

申请日：2020-09-11

Applicant: EDITAS MEDICINE, INC.

Inventor： Jennifer Leah Gori ,  Edouard Aupepin De Lamothe-Dreuzy ,  Jack Heath ,  John Anthony Zuris ,  KaiHsin Chang

IPC: C12N15/113 ,  A61K9/00

CPC classification number: C12N15/113 ,  A61K9/0009 ,  C12N2310/313

Abstract: Genome editing systems, guide RNAs, and CRISPR-mediated methods are provided for altering portions of the HBG1 and HBG2 loci, portions of the erythroid specific enhancer of the BCL11A gene, or a combination thereof, in cells and increasing expression of fetal hemoglobin.

公开(公告)号：US20230002760A1

公开(公告)日：2023-01-05

申请号：US17572403

申请日：2022-01-10

Applicant: Editas Medicine, Inc.

Inventor： Gordon Grant Welstead ,  Jennifer Leah Gori ,  Jack Michael Heath ,  David A. Bumcrot

IPC: C12N15/11 ,  C12N15/113 ,  A61P7/00 ,  A61K35/17 ,  C12N5/0783 ,  C12N9/22 ,  C12N9/96

Abstract: CRISPR/Cas-related compositions and methods which provide for efficient gene editing of eukaryotic cells using modified gRNAs.

公开(公告)号：US20180119123A1

公开(公告)日：2018-05-03

申请号：US15809549

申请日：2017-11-10

Applicant: EDITAS MEDICINE, INC.

Inventor： Jennifer Leah Gori ,  G. Grant Welstead ,  Penrose Odonnell

IPC: C12N9/22 ,  A61K38/46 ,  C12N15/113

CPC classification number: C12N9/22 ,  A61K31/713 ,  A61K38/465 ,  A61K48/00 ,  C12N15/1138 ,  C12N2310/10 ,  C12N2310/20 ,  C12N2310/317 ,  C12N2320/34

Abstract: CRISPR/CAS-related systems, compositions and methods for editing CCR5 and/or CXCR4 genes in human cells are described, as are cells and compositions including cells edited according to the same.

公开(公告)号：US20240252543A1

公开(公告)日：2024-08-01

申请号：US18544946

申请日：2023-12-19

Applicant: Editas Medicine, Inc.

Inventor： Jennifer Leah Gori ,  Tongyao Wang ,  Hariharan Jayaram ,  Penrose ODonnell

IPC: A61K35/28 ,  C07K14/74 ,  C12N5/0789 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86 ,  G16B40/00 ,  G16B50/00

CPC classification number: A61K35/28 ,  C07K14/70539 ,  C12N5/0647 ,  C12N9/22 ,  C12N15/11 ,  C12N15/111 ,  C12N15/86 ,  G16B40/00 ,  G16B50/00 ,  C12N2310/20

Abstract: Disclosed herein are compositions and methods for increasing the immunocompatibility of donor cells (e.g., HSCs or T-cells) for transplantation to a recipient subject, as well as database schemes for use in the methods. The methods and compositions described herein result in the allele-specific modification of one or more immunogenicity genes (e.g., an HLA gene) of a cell, resulting in cells that are suitable for transplantation into a recipient subject.

公开(公告)号：US11911415B2

公开(公告)日：2024-02-27

申请号：US15579633

申请日：2016-06-09

Applicant: EDITAS MEDICINE, INC.

Inventor： Jennifer Leah Gori ,  Tongyao Wang ,  Hariharan Jayaram ,  Penrose ODonnell

IPC: C12N5/078 ,  A61K35/14 ,  C12N15/113 ,  C12N15/31 ,  G16B50/00 ,  A61K35/28 ,  G16B40/00 ,  C12N15/11 ,  C07K14/74 ,  C12N5/0789 ,  C12N9/22 ,  C12N15/86

CPC classification number: A61K35/28 ,  C07K14/70539 ,  C12N5/0647 ,  C12N9/22 ,  C12N15/11 ,  C12N15/111 ,  C12N15/86 ,  G16B40/00 ,  G16B50/00 ,  C12N2310/20

Abstract: Disclosed herein are compositions and methods for increasing the immunocompatibility of donor cells (e.g., HSCs or T-cells) for transplantation to a recipient subject, as well as database schemes for use in the methods. The methods and compositions described herein result in the allele-specific modification of one or more immunogenicity genes (e.g., an HLA gene) of a cell, resulting in cells that are suitable for transplantation into a recipient subject.

公开(公告)号：US20160281111A1

公开(公告)日：2016-09-29

申请号：US15081456

申请日：2016-03-25

Applicant: Editas Medicine, Inc.

Inventor： Cecilia Cotta-Ramusino ,  Jennifer Leah Gori

IPC: C12N15/90 ,  A61K48/00 ,  A61K38/46 ,  C12N9/22

CPC classification number: A61K38/465 ,  A61K48/005 ,  C12N9/22 ,  C12N15/102 ,  C12Y301/00

Abstract: CRISPR/CAS-related compositions and methods for altering a cell or treating a disease, for example, by gene conversion, are disclosed.

Abstract translation: 公开了CRISPR / CAS相关的组合物和用于改变细胞或治疗疾病的方法，例如通过基因转化。

公开(公告)号：US11963982B2

公开(公告)日：2024-04-23

申请号：US16678912

申请日：2019-11-08

Applicant: Editas Medicine, Inc.

Inventor： Edouard Aupepin De Lamothe-Dreuzy ,  Jack Heath ,  Jennifer Leah Gori ,  Luis Barrera

IPC: C12N15/11 ,  A61K35/18 ,  C12N5/078 ,  C12N5/0789 ,  C12N9/22 ,  C12N15/90

CPC classification number: A61K35/18 ,  C12N5/0641 ,  C12N5/0647 ,  C12N9/22 ,  C12N15/111 ,  C12N15/907 ,  C12N2310/20 ,  C12N2320/10 ,  C12N2320/30

Abstract: Genome editing systems, guide RNAs, dead guide RNAs, and CRISPR-mediated methods are provided for altering portions of a target nucleic acid.

公开(公告)号：US11851690B2

公开(公告)日：2023-12-26

申请号：US16569336

申请日：2019-09-12

Applicant: EDITAS MEDICINE, INC.

Inventor： Jennifer Leah Gori ,  Luis A. Barrera ,  Edouard Aupepin De Lamothe-Dreuzy ,  Jack Heath

IPC: C07H21/02 ,  C12N9/22 ,  C12N15/11 ,  A61K31/7105 ,  A61K38/46

CPC classification number: C12N9/22 ,  A61K31/7105 ,  A61K38/465 ,  C12N15/111 ,  C12N2310/20 ,  C12N2320/30

Abstract: Genome editing systems, guide RNAs, and CRISPR-mediated methods are provided for altering portions of the HBG1 and HBG2 loci, portions of the erythroid specific enhancer of the BCL11A gene, or a combination thereof, in cells and increasing expression of fetal hemoglobin.

公开(公告)号：US20230126434A1

公开(公告)日：2023-04-27

申请号：US17836165

申请日：2022-06-09

Applicant: Editas Medicine, Inc.

Inventor： Jennifer Leah Gori

IPC: C12N15/87 ,  A61K35/28 ,  C07K14/315 ,  C12N5/0789 ,  C12N9/22 ,  A01K67/027 ,  C12N15/10 ,  A61K35/17 ,  A61K35/545

Abstract: The methods and compositions described herein surprisingly increase CRISPR/Cas-mediated gene editing in stem cells by transiently treating the cells with a stem cell viability enhancer prior to and/or after contacting the cells with one or more CRISPR/Cas9 components. Further, this treatment also surprisingly results in increased engraftment of the stem cells into the target tissue of a subject. The present disclosure also provides one or more modified CRISPR/Cas9 components which, when used in combination with the stem cell viability enhancer, further increases the frequency of gene editing in stem cells, increases stem cell viability, and increases stem cell engraftment.