公开(公告)号：US10294499B2

公开(公告)日：2019-05-21

申请号：US15575481

申请日：2016-05-27

申请人： EVOLVA SA

发明人： Ernesto Simon Vecilla ,  Beata Joanna Lehka ,  Carlos Casado Vazquez

IPC分类号： C12P7/42 ,  C12N9/88 ,  C12P7/22 ,  C12N1/16 ,  C12N1/20 ,  C12P13/22

摘要： Provided herein are recombinant hosts and methods for producing phenylpropanoid and phenylpropanoid derivative compounds. It was found that tyrosine ammonia lyase from Aeromonas salmonicida A449 provides improved coumaric acid production.

公开(公告)号：US10760062B2

公开(公告)日：2020-09-01

申请号：US15579415

申请日：2016-06-06

申请人： EVOLVA SA

发明人： Michael Naesby ,  Ernesto Simón Vecilla ,  Michael Eichenberger ,  Beata Joanna Lehka ,  Walden Emil Bjørn-Yoshimoto ,  Niels Bjerg Jensen

IPC分类号： C12N9/02 ,  C12P7/26 ,  C12P19/44 ,  C12P7/22 ,  C12N9/10 ,  C12N15/81 ,  C12N9/06

摘要： Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds.