公开(公告)号：US20190276415A1

公开(公告)日：2019-09-12

申请号：US16426024

申请日：2019-05-30

Applicant: ESTEVE PHARMACEUTICALS, S.A.

Inventor： Félix CUEVAS-CORDOBÉS ,  Carmen ALMANSA-ROSALES ,  Monica GARCIA-LOPEZ

IPC: C07D249/06 ,  C07D401/12 ,  C07D401/06 ,  C07D487/08 ,  C07D487/04 ,  C07D401/14 ,  C07D403/06 ,  C07D401/04 ,  C07D233/64 ,  C07D231/12 ,  C07D249/04

Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to piperazine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US20190241544A1

公开(公告)日：2019-08-08

申请号：US16301508

申请日：2017-05-19

Applicant: ESTEVE PHARMACEUTICALS, S.A.

Inventor： Monica GARCIA-LOPEZ ,  Carmen ALMANSA-ROSALES ,  Ana Virginia LLORENTE-FERNANDEZ ,  Ute CHRISTMANN ,  Sergio RODRIGUEZ ESCRICH

IPC: C07D405/04 ,  A61P29/00 ,  C07D405/14 ,  C07D487/04

Abstract: The present invention relates to tetrahydropyran and thiopyran derivatives having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US20220380345A1

公开(公告)日：2022-12-01

申请号：US17764257

申请日：2020-10-05

Applicant: ESTEVE PHARMACEUTICALS, S.A.

Inventor： Carmen ALMANSA-ROSALES ,  Ariadna FERNANDEZ-DONIS ,  José-Luís DÍAZ-FERNÁNDEZ ,  Monica GARCIA-LOPEZ ,  Sergi RODRIGUEZ-ESCRICH ,  Ute CHRISTMANN

IPC: C07D403/06 ,  C07D471/08 ,  C07D471/04

Abstract: The present invention relates to homopiperazinyl and homopiperidinyl quinazolin-4(3H)-one derivatives having dual pharmacological activity towards both the α2δ subunit of the voltage-gated calcium channel and the sigma-1 (σ1) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US20200010457A1

公开(公告)日：2020-01-09

申请号：US16469733

申请日：2017-12-15

Applicant: ESTEVE PHARMACEUTICALS, S.A.

Inventor： Monica GARCIA-LOPEZ ,  Carmen ALMANSA-ROSALES

IPC: C07D405/12

Abstract: The present invention relates to tetrahydropyran and tetrahydrothiopyran amide derivatives having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.