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公开(公告)号：US11964055B2
公开(公告)日：2024-04-23
申请号：US17504087
申请日：2021-10-18
申请人： ESTETRA SRL
发明人： Séverine Francine Isabelle Jaspart , Johannes Jan Platteeuw , Denny Johan Marijn Van Den Heuvel
CPC分类号： A61K9/2095 , A61K9/0056 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K31/565 , A61P5/00 , A61P15/18 , A61K9/1623
摘要： The invention provides an orodispersible solid pharmaceutical dosage unit having a weight between 30 and 1,000 mg, said dosage unit consisting of: 0.1-25 wt. % of estetrol particles containing at least 80 wt. % of an estetrol component selected from estetrol, estetrol esters and combinations thereof; and 75-99.9 wt. % of one or more pharmaceutically acceptable ingredients; the solid dosage unit comprising at least 100 μg of the estetrol component; and wherein the solid dosage unit can be obtained by a process comprising wet granulation of estetrol particles having a volume weighted average particle size of 2 μm to 50 μm. The solid dosage unit is easy to manufacture and perfectly suited for sublingual, buccal or sublabial administration.
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公开(公告)号：US11957694B2
公开(公告)日：2024-04-16
申请号：US16883052
申请日：2020-05-26
申请人： ESTETRA SRL
发明人： Séverine Francine Isabelle Jaspart , Johannes Jan Platteeuw , Denny Johan Marijn Van Den Heuvel
IPC分类号： A61K31/565 , A61K9/00 , A61K9/20
CPC分类号： A61K31/565 , A61K9/0056 , A61K9/006 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K9/2077 , A61K9/2095
摘要： An orodispersible solid pharmaceutical dosage unit of estetrol is disclosed. The solid dosage unit is easy to manufacture and suited for sublingual, buccal or sublabial administration. The orodispersible solid pharmaceutical dosage unit can include at least 100 μg of an estetrol component and pharmaceutically acceptable excipients. Methods of manufacturing the orodispersible solid pharmaceutical dosage unit are also disclosed.
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公开(公告)号：US11793760B2
公开(公告)日：2023-10-24
申请号：US18196617
申请日：2023-05-12
申请人： ESTETRA SRL
发明人： Séverine Francine Isabelle Jaspart , Johannes Jan Platteeuw , Denny Johan Marijn Van Den Heuvel
CPC分类号： A61K9/2095 , A61K9/0056 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K31/565 , A61P5/00 , A61P15/18 , A61K9/1623
摘要： The invention provides an orodispersible solid pharmaceutical dosage unit having a weight between 30 and 1,000 mg, said dosage unit consisting of: 0.1-25 wt. % of estetrol particles containing at least 80 wt. % of an estetrol component selected from estetrol, estetrol esters and combinations thereof; and 75-99.9 wt. % of one or more pharmaceutically acceptable ingredients; the solid dosage unit comprising at least 100 μg of the estetrol component; and wherein the solid dosage unit can be obtained by a process comprising wet granulation of estetrol particles having a volume weighted average particle size of 2 μm to 50 μm. The solid dosage unit is easy to manufacture and perfectly suited for sublingual, buccal or sublabial administration.
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