公开(公告)号：US11673905B2

公开(公告)日：2023-06-13

申请号：US15776232

申请日：2016-11-10

Applicant: ELC Management LLC ,  ISP Investments LLC

Inventor： Elodie Oger ,  Rachel Chabert ,  Isabelle Imbert ,  Jean-Marie Botto ,  Nouha Domloge ,  Joel Mantelin ,  Nadine Pernodet ,  Kelly Dong ,  Chia-Wen Chen

IPC: A61K8/44 ,  C07H1/08 ,  A61K8/60 ,  C07H21/02 ,  A61Q19/08 ,  A61K8/9789 ,  C12N15/10 ,  A61Q19/00 ,  A61Q17/04 ,  A61K8/9794

CPC classification number: C07H1/08 ,  A61K8/44 ,  A61K8/606 ,  A61K8/9789 ,  A61K8/9794 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08 ,  C07H21/02 ,  C12N15/1003 ,  C12N15/1017 ,  A61K2800/10 ,  A61K2800/30 ,  A61K2800/805

Abstract: The invention relates to a topical composition comprising an extract of Tiger lily (Lilium tigrinum) enriched in low molecular weight RNA. The invention also relates to a method of cosmetic care including the topical application a composition comprising an extract of Tiger lily (Lilium tigrinum) in a physiologically acceptable medium, in order to reduce skin signs of aging and photo-aging. The invention is also directed to a cosmetic method of treatment to improve cell viability, to improve cell protection against particulate matter and against DNA damages, and to reduce cellular senescence.

公开(公告)号：US10555895B2

公开(公告)日：2020-02-11

申请号：US16330020

申请日：2017-09-06

Applicant: ISP Investments LLC ,  ELC Management LLC

Inventor： Nadine Pernodet ,  Dawn Layman ,  Jean-Marie Botto ,  Elodie Oger ,  Audrey Le Mestr ,  Isabelle Imbert ,  Nouha Domloge

IPC: A61K36/00 ,  A61K8/9789 ,  A61Q19/08 ,  A61Q17/04 ,  A61K8/34 ,  A61K8/60 ,  A61K8/64

Abstract: The present invention provides a process for obtaining an extract from peach flower extract (Primus persica L.) for skin cosmetic use, a peach flower extract obtainable by the process and a cosmetic composition comprising the said extract. The invention further provides a method for modulating the SIRT2 expression, a method of treatment designed to reduce and/or correct the signs of aging and photo-aging of the skin and keratinous appendages, and to protect the skin against aggressions due to ultraviolet radiation.

公开(公告)号：US11248224B2

公开(公告)日：2022-02-15

申请号：US16612365

申请日：2018-04-27

Applicant: ISP Investments LLC

Inventor： Elodie Oger ,  Jean-Marie Botto

IPC: C12N5/10 ,  A61K8/9789 ,  C12N15/10 ,  A61Q19/08 ,  A61Q5/00 ,  A61Q19/00

Abstract: The invention relates to a method for obtaining an aqueous extract of Anethum graveolens, enriched with small RNAs having a maximum length of 150 nucleotides, from a plant material, said method comprising the following steps: a) aerial parts of dill is brought into contact with water; b) tetrasodium ethylenediaminetetraacetic acid (EDTA) is added at a pH of between 10.5 and 11; c) the pH of the mixture obtained in b) is then adjusted to a value of between 6 and 8; d) the mixture obtained in c) is purified; and e) the pH is checked and readjusted if necessary to a value of between 6 and 8. The invention also relates to an aqueous extract of Anethum graveolens, enriched with small RNAs having a maximum length of 150 nucleotides, obtained by the method.

公开(公告)号：US11021505B2

公开(公告)日：2021-06-01

申请号：US15774754

申请日：2016-11-10

Applicant: ISP INVESTMENTS LLC

Inventor： Elodie Oger ,  Valerie Lequoy ,  Frederique Portolan

IPC: C12N15/10 ,  C07H1/08 ,  A61K8/60 ,  C07H21/02 ,  A61Q19/08 ,  A61K8/9789 ,  A61Q19/00 ,  A61Q17/04 ,  A61K8/9794 ,  A61K8/44

Abstract: The invention relates to an aqueous extract enriched with small RNA having a maximum length of 150 nucleotides, from plant material. The invention relates to an aqueous extract of plant material, enriched with small RNAs having a maximum length of 150 nucleotides, which can be obtained by such a method, as well as to the compositions comprising such an extract and to their cosmetic uses for combating the signs of skin aging and for improving the hydration of the skin.