公开(公告)号：US20240035020A1

公开(公告)日：2024-02-01

申请号：US17932449

申请日：2022-09-15

Applicant: ELASMOGEN LTD

Inventor： Caroline Jane BARELLE ,  Marina KOVALEVA ,  Laura Ann FERGUSON ,  Obinna Chukwuemeka UBAH ,  Andrew Justin Radcliffe PORTER

IPC: C12N15/10 ,  C07K14/195

CPC classification number: C12N15/1082 ,  C07K14/195 ,  C07K2317/31 ,  C07K2317/24

Abstract: The present invention relates to a synthetic library of vvthumanised antigen specific binding molecules derived from a member of a species in the Elasmobranchii subclass, processes for the production thereof and specific antigen specific binding molecules isolated from said library. The present invention also relates to the multi-domain specific binding molecules comprising humanised Ig-like Novel Antigen Receptor variable domains (VNARs). Specific binding domains that bind to Tumour Necrosis Factor alpha (TNFα) are also provided.

公开(公告)号：US20240376639A1

公开(公告)日：2024-11-14

申请号：US18785856

申请日：2024-07-26

Applicant: ELASMOGEN LTD

Inventor： Caroline Jane BARELLE ,  Marina KOVALEVA ,  Laura Ann FERGUSON ,  Obinna Chukwuemeka UBAH ,  Andrew Justin Radcliffe PORTER

IPC: C40B50/06 ,  C07K14/195 ,  C12N15/10

Abstract: The present invention relates to a synthetic library of humanised antigen specific binding molecules derived from a member of a species in the Elasmobranchii subclass, processes for the production thereof 5 and specific antigen specific binding molecules isolated from said library. The present invention also relates to the multi-domain specific binding molecules comprising humanised Ig-like Novel Antigen Receptor variable domains (VNARs). Specific binding domains that bind to Tumour Necrosis Factor alpha (TNFα) are also provided.