公开(公告)号：US08617072B2

公开(公告)日：2013-12-31

申请号：US11569437

申请日：2005-05-20

Applicant: Dragos-Nicolae Peligrad ,  Lothar Spies ,  Timo Paulus

Inventor： Dragos-Nicolae Peligrad ,  Lothar Spies ,  Timo Paulus

IPC: A61B5/00

CPC classification number: G06F19/321 ,  G06F19/00 ,  G16H10/40

Abstract: The invention relates to a general composite compartmental model and a compartmental analysis procedure to extract non-invasively the concentration (Cp) of the imaging agent in plasma (301), in metabolites (304, 504) and in blood elements (303) (like red cells, platelets, plasma protein etc.) from time signal curves measured within a reference tissue region (200). This is made possible by deploying an injection function (SINJ(t)) as input which models the amount of imaging agent administered to the patient as a function of time. The invention allows the presentation of the plasma input function to the medical practitioner without the need for invasively drawing blood samples.

Abstract translation: 本发明涉及一般的复合区室模型和隔室分析程序，其非侵入性地提取血浆（301），代谢物（304,504）和血液元件（303）中的成像剂的浓度（Cp）（如 红细胞，血小板，血浆蛋白等）从参考组织区域（200）中测量的时间信号曲线。 这是通过部署注射功能（SINJ（t））作为对作为时间的函数对患者施用的成像剂的量进行建模的输入而实现的。 本发明允许向医生介绍等离子体输入功能，而不需要侵入性地抽取血液样本。

公开(公告)号：US20110060205A1

公开(公告)日：2011-03-10

申请号：US11569437

申请日：2005-05-20

Applicant: Dragos-Nicolae Peligrad ,  Lothar Spies ,  Timo Paulus

Inventor： Dragos-Nicolae Peligrad ,  Lothar Spies ,  Timo Paulus

IPC: A61B5/00

CPC classification number: G06F19/321 ,  G06F19/00 ,  G16H10/40

Abstract: The invention relates to a general composite compartmental model and a compartmental analysis procedure to extract non-invasively the concentration (Cp) of the imaging agent in plasma (301), in metabolites (304, 504) and in blood elements (303) (like red cells, platelets, plasma protein etc.) from time signal curves measured within a reference tissue region (200). This is made possible by deploying an injection function (SINJ(t)) as input which models the amount of imaging agent administered to the patient as a function of time. The invention allows the presentation of the plasma input function to the medical practitioner without the need for invasively drawing blood samples.

Abstract translation: 本发明涉及一般的复合区室模型和隔室分析程序，其非侵入性地提取血浆（301），代谢物（304,504）和血液元件（303）中的成像剂的浓度（Cp）（如 红细胞，血小板，血浆蛋白等）从参考组织区域（200）中测量的时间信号曲线。 这是通过部署注射功能（SINJ（t））作为对作为时间的函数对患者施用的成像剂的量进行建模的输入而实现的。 本发明允许向医生介绍等离子体输入功能，而不需要侵入性地抽取血液样本。

公开(公告)号：US20070219729A1

公开(公告)日：2007-09-20

申请号：US11569441

申请日：2005-05-23

Applicant: Dragos-Nicolae Peligrad ,  Lothar Spies ,  Timo Paulus

Inventor： Dragos-Nicolae Peligrad ,  Lothar Spies ,  Timo Paulus

IPC: G06F19/00 ,  A61B5/00 ,  G01N33/48

CPC classification number: G06T7/20 ,  G06F19/321 ,  G06T2207/10072 ,  G06T2207/30004 ,  G16H50/50

Abstract: The invention relates to the estimation of kinetic parameters for a target region (210) utilizing information from a normal (unperturbed) reference region (200). The proposed compartmental model models metabolic pathways for blood, reference and target tissue. The proposed analysis procedure features two alternatives: (A) Extraction of the plasma input in the reference region (200) and its unperturbed kinetic parameters, hereafter utilization of the plasma input and the kinetic parameters of the reference region as initial parameters for the analysis of the target region (210). (B) The system of kinetic equations describing the kinetics of the imaging agent in the target and reference regions is solved for the input function (amount of free imaging agent in the plasma or the total imaging agent SB(t) contained in plasma, blood elements and metabolites) considered to be the same for both regions.

Abstract translation: 本发明涉及利用来自正常（未扰动）参考区域（200）的信息估计目标区域（210）的动力学参数。 提出的区室模型为血液，参考和靶组织建立代谢途径。 提出的分析程序具有两个选择：（A）参考区域（200）中的等离子体输入的提取及其未扰动的动力学参数，此后使用等离子体输入和参考区域的动力学参数作为分析初始参数 目标区域（210）。 （B）解决了描述目标和参考区域中成像剂的动力学的动力学方程的系统，用于输入功能（等离子体中的游离显像剂的量或血浆中的总成像剂SB（t），血液 元素和代谢物）被认为是相同的两个地区。

公开(公告)号：US20070165926A1

公开(公告)日：2007-07-19

申请号：US11568704

申请日：2005-05-03

Applicant: Timo Paulus ,  Dragos-Nicolae Peligrad ,  Lothar Spies

Inventor： Timo Paulus ,  Dragos-Nicolae Peligrad ,  Lothar Spies

IPC: G06K9/00

CPC classification number: G06T7/0012 ,  G06F19/321 ,  G06T2200/04 ,  G06T2207/10104 ,  G06T2207/20092 ,  G06T2207/30004

Abstract: The invention relates to a data processing system (1) for the evaluation of image data, particularly of PET-images (I), that represent the time varying concentration of a tracer substance like F-MISO in an object (20). The data processing system (1) comprises a library module (48) with analytical solutions (Cj(t)) for several compartment models. Preferably the library also contains the analytical gradients with respect to the parameters of interest. From the library an appropriate solution for each study can be chosen by a user. The use of analytical functions together with the information about the error (σA(t)) of the input data (either via noise models 43 or via a simulation 44) allows to extract all parameters mandatory to fully understand the kinetics of complex models (more than one tissue compartment) on a per-voxel basis in a robust way in real-time.

Abstract translation: 本发明涉及一种用于评价特定于PET图像（I）的图像数据的数据处理系统（1），其表示物体（20）中的示踪物质如F-MISO的时变浓度。 数据处理系统（1）包括具有用于几个隔室模型的分析解决方案（C（j））的库模块（48）。 优选地，库还包含关于感兴趣的参数的分析梯度。 从图书馆，每个研究的适当解决方案可由用户选择。 使用分析功能以及关于输入数据（通过噪声模型43或经由模拟44）的错误信息（西格玛）可以允许 提取所有必要的参数，以实时的方式，以健壮的方式充分了解复杂模型（多于一个组织室）的动力学。

公开(公告)号：US20100201686A1

公开(公告)日：2010-08-12

申请号：US12671244

申请日：2007-08-03

Applicant: Timo Paulus ,  Alexander Fischer ,  Lothar Spies

Inventor： Timo Paulus ,  Alexander Fischer ,  Lothar Spies

IPC: G06T17/00

CPC classification number: H04L51/14

Abstract: Methods and systems for interworking in messaging systems are described. An event store can be accessible by different dispatchers associated with different message servers. The dispatchers may be co-located with the event store or non co-located with the event store.

Abstract translation: 描述了消息系统中互通的方法和系统。 可以通过与不同消息服务器相关联的不同调度器访问事件存储。 调度员可以与事件存储共同定位，也可以与事件存储不同。

公开(公告)号：US08103609B2

公开(公告)日：2012-01-24

申请号：US12067481

申请日：2006-09-13

Applicant: Alexander Fischer ,  Lothar Spies

Inventor： Alexander Fischer ,  Lothar Spies

IPC: G06F17/00 ,  G06N5/02

CPC classification number: G06T7/0012 ,  A61B5/055 ,  G01R33/5608 ,  G06K9/3233 ,  G06K2209/05 ,  G06T7/11 ,  G06T2207/30004

Abstract: A system, apparatus, and method are based on a priori knowledge of the shape of the input function for defining an input region-if-interest (ROI) in pharmacokinetic modeling. Kinetic parameter estimation requires knowledge of tracer input activity and the present invention provides an automatic way to define an ROI for estimation of an input function that takes into account a priori knowledge of the shape of the input function based on an administered dose.

Abstract translation: 系统，装置和方法基于用于在药代动力学建模中定义输入区域 - 如果兴趣（ROI）的输入函数的形状的先验知识。 动力学参数估计需要了解示踪剂输入活动的知识，并且本发明提供了一种自动方式来定义用于估计输入功能的ROI，其基于施用的剂量考虑到输入功能的形状的先验知识。

公开(公告)号：US08064672B2

公开(公告)日：2011-11-22

申请号：US12088088

申请日：2006-09-15

Applicant: Manoj Narayanan ,  Bart Jacob Bakker ,  Daniel Gagnon ,  Alexander Fischer ,  Lothar Spies

Inventor： Manoj Narayanan ,  Bart Jacob Bakker ,  Daniel Gagnon ,  Alexander Fischer ,  Lothar Spies

IPC: G06K9/00

CPC classification number: A61B6/00 ,  A61B6/037

Abstract: An imaging system (10) comprises a data device (30), which controls radiation data acquisition from a subject positioned in an examination region (18) for an examination. A rebinning processor (40) bins the acquired data periodically into a histogram (42). A transform (70) transforms the histogram (42) into individual independent or uncorrelated components, each component including a signal content and a noise content. A stopping determining device (52) compares an aspect of at least one selected component to a predetermined threshold (TH) and, based on the comparison, terminates the data acquisition.

Abstract translation: 成像系统（10）包括数据装置（30），其控制从位于检查区域（18）中的被摄体进行检查的辐射数据采集。 重组处理器（40）将获取的数据周期性地存储到直方图（42）中。 变换（70）将直方图（42）变换为独立的或不相关的分量，每个分量包括信号内容和噪声内容。 停止确定装置（52）将至少一个所选择的组件的方面与预定阈值（TH）进行比较，并且基于该比较，终止数据采集。

公开(公告)号：US07787669B2

公开(公告)日：2010-08-31

申请号：US10543567

申请日：2004-01-19

Applicant: Henrik Botterweck ,  Lothar Spies

Inventor： Henrik Botterweck ,  Lothar Spies

IPC: G06K9/00

CPC classification number: A61B6/032 ,  A61N5/1031 ,  Y10S128/922

Abstract: In order to reduce an x-ray dose applied to a patient, it is necessary to know the dose absorbed by the patient. According to the present invention, there is provided a method of determining a local patient dose applied to a patient where after the reconstruction of the scan data into a diagnostic image, the scan data are backprojected into the patient volume, using the attenuation information of the diagnostic image to form a spatially varying photon fluence map. In parallel, the diagnostic image is segmented into anatomical structures to which dose-weighting factors are assigned. The locally absorbed dose is then calculated on the basis of the fluence map and the corresponding dose weights.

Abstract translation: 为了减少施加到患者的x射线剂量，需要知道患者吸收的剂量。 根据本发明，提供了一种确定施用于患者的局部患者剂量的方法，其中在将扫描数据重建为诊断图像之后，使用所述扫描数据的衰减信息将扫描数据反向投影到患者体积中 诊断图像形成空间变化的光子注量图。 并行地，诊断图像被分割成分配给剂量加权因子的解剖结构。 然后根据注量图和相应的剂量重量计算局部吸收剂量。

公开(公告)号：US07991243B2

公开(公告)日：2011-08-02

申请号：US11815215

申请日：2006-02-01

Applicant: Matthieu Bal ,  Hasan Celik ,  Kai Eck ,  Lothar Spies ,  Krishna Subramanyan

Inventor： Matthieu Bal ,  Hasan Celik ,  Kai Eck ,  Lothar Spies ,  Krishna Subramanyan

IPC: G06K9/40 ,  G06K9/00 ,  A61B6/00

CPC classification number: G06T11/008

Abstract: A diagnostic imaging system (10) corrects metal artifact streaks (38) emanating from a metal object (36) in a tomographic image (T). A first processor (40) reduces streaks (38) caused by mild artifacts by applying an adaptive filter (82). The filter (82) is perpendicularly oriented toward the center of the metal object (36). The weight of the filter (82) is a function of the local structure tensor and the vector pointing to the metal object (36). If it is determined that the strong artifacts are present in the image, a second processor (48) applies a sinogram completed image algorithm to correct for severe artifacts in the image. The sinogram completed image and adaptively filtered image are fused to a final corrected image. In the fusion process, highly corrupted tomographic regions are replaced by the result of the sinogram completed image and the remainder is replaced by the adaptively filtered image.

Abstract translation: 诊断成像系统（10）校正在断层图像（T）中从金属物体（36）发出的金属假象条纹（38）。 第一处理器（40）通过应用自适应滤波器（82）来减少由温和伪影引起的条纹（38）。 过滤器（82）朝向金属物体（36）的中心垂直取向。 过滤器（82）的重量是局部结构张量和指向金属物体（36）的矢量的函数。 如果确定图像中存在强伪像，则第二处理器（48）施加正弦图完成图像算法以校正图像中的严重伪像。 正弦图完成图像和自适应滤波图像融合到最终校正图像。 在融合过程中，高度破坏的断层摄影区域被正弦图完成图像的结果所替代，其余部分由自适应滤波图像代替。

公开(公告)号：US07636420B2

公开(公告)日：2009-12-22

申请号：US11914765

申请日：2006-05-01

Applicant: Lothar Spies ,  Matthieu Bal ,  Todd McNutt

Inventor： Lothar Spies ,  Matthieu Bal ,  Todd McNutt

IPC: A61N5/10 ,  H05G1/42

CPC classification number: A61N5/103 ,  A61B6/03 ,  A61N5/1039 ,  A61N5/1042

Abstract: A radiation therapy planning procedure and device provides a model-based segmentation of co-registered anatomical and functional imaging information to provide a more precise radiation therapy plan. The biology-based segmentation models the imaging information to produce a parametric map, which is then clustered into regions of similar radiation sensitivity or other biological parameters relevant for treatment definition. Each clustered region is prescribed its own radiation prescription dose.

Abstract translation: 辐射治疗计划程序和装置提供共同注册的解剖和功能成像信息的基于模型的分割，以提供更精确的放射治疗计划。 基于生物学的分割模拟成像信息以产生参数图，然后将其聚类到具有相似辐射敏感性的区域或与治疗定义相关的其他生物参数。 每个聚簇区域规定自己的辐射处方剂量。