公开(公告)号：US07991243B2

公开(公告)日：2011-08-02

申请号：US11815215

申请日：2006-02-01

Applicant: Matthieu Bal ,  Hasan Celik ,  Kai Eck ,  Lothar Spies ,  Krishna Subramanyan

Inventor： Matthieu Bal ,  Hasan Celik ,  Kai Eck ,  Lothar Spies ,  Krishna Subramanyan

IPC: G06K9/40 ,  G06K9/00 ,  A61B6/00

CPC classification number: G06T11/008

Abstract: A diagnostic imaging system (10) corrects metal artifact streaks (38) emanating from a metal object (36) in a tomographic image (T). A first processor (40) reduces streaks (38) caused by mild artifacts by applying an adaptive filter (82). The filter (82) is perpendicularly oriented toward the center of the metal object (36). The weight of the filter (82) is a function of the local structure tensor and the vector pointing to the metal object (36). If it is determined that the strong artifacts are present in the image, a second processor (48) applies a sinogram completed image algorithm to correct for severe artifacts in the image. The sinogram completed image and adaptively filtered image are fused to a final corrected image. In the fusion process, highly corrupted tomographic regions are replaced by the result of the sinogram completed image and the remainder is replaced by the adaptively filtered image.

Abstract translation: 诊断成像系统（10）校正在断层图像（T）中从金属物体（36）发出的金属假象条纹（38）。 第一处理器（40）通过应用自适应滤波器（82）来减少由温和伪影引起的条纹（38）。 过滤器（82）朝向金属物体（36）的中心垂直取向。 过滤器（82）的重量是局部结构张量和指向金属物体（36）的矢量的函数。 如果确定图像中存在强伪像，则第二处理器（48）施加正弦图完成图像算法以校正图像中的严重伪像。 正弦图完成图像和自适应滤波图像融合到最终校正图像。 在融合过程中，高度破坏的断层摄影区域被正弦图完成图像的结果所替代，其余部分由自适应滤波图像代替。

公开(公告)号：US07636420B2

公开(公告)日：2009-12-22

申请号：US11914765

申请日：2006-05-01

Applicant: Lothar Spies ,  Matthieu Bal ,  Todd McNutt

Inventor： Lothar Spies ,  Matthieu Bal ,  Todd McNutt

IPC: A61N5/10 ,  H05G1/42

CPC classification number: A61N5/103 ,  A61B6/03 ,  A61N5/1039 ,  A61N5/1042

Abstract: A radiation therapy planning procedure and device provides a model-based segmentation of co-registered anatomical and functional imaging information to provide a more precise radiation therapy plan. The biology-based segmentation models the imaging information to produce a parametric map, which is then clustered into regions of similar radiation sensitivity or other biological parameters relevant for treatment definition. Each clustered region is prescribed its own radiation prescription dose.

Abstract translation: 辐射治疗计划程序和装置提供共同注册的解剖和功能成像信息的基于模型的分割，以提供更精确的放射治疗计划。 基于生物学的分割模拟成像信息以产生参数图，然后将其聚类到具有相似辐射敏感性的区域或与治疗定义相关的其他生物参数。 每个聚簇区域规定自己的辐射处方剂量。

公开(公告)号：US20080267351A1

公开(公告)日：2008-10-30

申请号：US11914765

申请日：2006-05-01

Applicant: Lothar Spies ,  Matthieu Bal ,  Todd McNutt

Inventor： Lothar Spies ,  Matthieu Bal ,  Todd McNutt

IPC: A61N5/10 ,  H05G1/42

CPC classification number: A61N5/103 ,  A61B6/03 ,  A61N5/1039 ,  A61N5/1042

Abstract: A radiation therapy planning procedure and device provides a model-based segmentation of co-registered anatomical and functional imaging information to provide a more precise radiation therapy plan. The biology-based segmentation models the imaging information to produce a parametric map, which is then clustered into regions of similar radiation sensitivity or other biological parameters relevant for treatment definition. Each clustered region is prescribed its own radiation prescription dose.

Abstract translation: 辐射治疗计划程序和装置提供共同注册的解剖和功能成像信息的基于模型的分割，以提供更精确的放射治疗计划。 基于生物学的分割模拟成像信息以产生参数图，然后将其聚类到具有相似辐射敏感性的区域或与治疗定义相关的其他生物参数。 每个聚簇区域规定自己的辐射处方剂量。

公开(公告)号：US09076222B2

公开(公告)日：2015-07-07

申请号：US13511670

申请日：2010-11-18

Applicant: Matthieu Bal

Inventor： Matthieu Bal

IPC: A61B6/00 ,  A61N5/10 ,  G06T7/00 ,  A61B5/00

CPC classification number: G06T7/0083 ,  A61B5/0033 ,  A61B5/004 ,  A61B6/52 ,  A61B6/5211 ,  A61B6/5229 ,  A61N5/103 ,  A61N5/1039 ,  G06T7/12 ,  G06T2207/10072 ,  G06T2207/30096

Abstract: A radiation therapy system includes a diagnostic image scanner (12) which acquires a multidimensional dataset of a subject that is reconstructed into at least one image representation of an object of interest. An image processing apparatus (72), of radiation therapy system, includes a segmentation unit (74) which identifies a surface contour of the object of interest, or other critical structures. A masking unit (82) determines a non-constant margin, based on the identified surface contour and appends the determined non-constant margin to the identified surface contour. The non-constant margin is based on at least one of anisotropic motion, surface morphology, positional uncertainty, proximity to other organs, and probability of dose distribution. A planning processor (70) generates a radiation therapy plan which limits the delivery of therapeutic radiation to anatomy associated with the surface contour and appended non-constant margin. A radiation delivery system (40) delivers therapeutic radiation according to the generated plan.

Abstract translation: 一种放射治疗系统包括诊断图像扫描器（12），该诊断图像扫描仪（12）获取将被重建为感兴趣对象的至少一个图像表示的被摄体的多维数据集。 放射治疗系统的图像处理装置（72）包括识别感兴趣对象的表面轮廓或其他关键结构的分割单元（74）。 掩蔽单元（82）基于所识别的表面轮廓确定非恒定余量，并将所确定的不恒定余量附加到所识别的表面轮廓。 非恒定余量基于各向异性运动，表面形态，位置不确定性，与其他器官的接近度以及剂量分布概率中的至少一个。 规划处理器（70）产生辐射治疗计划，其限制将治疗辐射递送到与表面轮廓相关联的解剖结构和附加的非恒定边缘。 辐射递送系统（40）根据生成的计划递送治疗辐射。

公开(公告)号：US08306185B2

公开(公告)日：2012-11-06

申请号：US11573564

申请日：2005-07-28

Applicant: Matthieu Bal ,  Lothar Spies ,  Todd R. McNutt

Inventor： Matthieu Bal ,  Lothar Spies ,  Todd R. McNutt

IPC: A61N5/10

CPC classification number: A61N5/103 ,  A61N5/1031 ,  A61N2005/1061 ,  G06F19/00 ,  G06F19/3481

Abstract: In a radiation therapy method, one or more planning images are acquired (102) of a subject. Features of at least malignant tissue are contoured in the one or more planning images to produce one or more initial feature contours. One or more treatment images of the subject are acquired (114). The one or more initial feature contours are updated (122) based on the one or more treatment images. Radiation treatment parameters are optimized (126) based upon the updated one or more feature contours. Radiation treatment of the subject is performed (130) using the optimized parameters.

Abstract translation: 在放射治疗方法中，获取对象的一个​​或多个规划图像（102）。 至少恶性组织的特征在一个或多个规划图像中具有轮廓，以产生一个或多个初始特征轮廓。 获取对象的一个​​或多个处理图像（114）。 一个或多个初始特征轮廓基于一个或多个治疗图像被更新（122）。 基于更新的一个或多个特征轮廓对辐射处理参数进行优化（126）。 使用优化的参数进行受试者的放射治疗（130）。

公开(公告)号：US20080152203A1

公开(公告)日：2008-06-26

申请号：US11815215

申请日：2006-02-01

Applicant: Matthieu Bal ,  Hasan Celik ,  Kai Eck ,  Lothar Spies ,  Krishna Subramanyan

Inventor： Matthieu Bal ,  Hasan Celik ,  Kai Eck ,  Lothar Spies ,  Krishna Subramanyan

IPC: G06K9/00

CPC classification number: G06T11/008

Abstract: A diagnostic imaging system (10) corrects metal artifact streaks (38) emanating from a metal object (36) in a tomographic image (T). A first processor (40) reduces streaks (38) caused by mild artifacts by applying an adaptive filter (82). The filter (82) is perpendicularly oriented toward the center of the metal object (36). The weight of the filter (82) is a function of the local structure tensor and the vector pointing to the metal object (36). If it is determined that the strong artifacts are present in the image, a second processor (48) applies a sinogram completed image algorithm to correct for severe artifacts in the image. The sinogram completed image and adaptively filtered image are fused to a final corrected image. In the fusion process, highly corrupted tomographic regions are replaced by the result of the sinogram completed image and the remainder is replaced by the adaptively filtered image.

Abstract translation: 诊断成像系统（10）校正在断层图像（T）中从金属物体（36）发出的金属假象条纹（38）。 第一处理器（40）通过应用自适应滤波器（82）来减少由温和伪影引起的条纹（38）。 过滤器（82）朝向金属物体（36）的中心垂直取向。 过滤器（82）的重量是局部结构张量和指向金属物体（36）的向量的函数。 如果确定图像中存在强伪像，则第二处理器（48）施加正弦图完成图像算法以校正图像中的严重伪像。 正弦图完成图像和自适应滤波图像融合到最终校正图像。 在融合过程中，高度破坏的断层摄影区域被正弦图完成图像的结果所替代，其余部分由自适应滤波图像代替。

公开(公告)号：US20120280135A1

公开(公告)日：2012-11-08

申请号：US13511670

申请日：2010-11-18

Applicant: Matthieu Bal

Inventor： Matthieu Bal

IPC: G06K9/00 ,  A61N5/10

CPC classification number: G06T7/0083 ,  A61B5/0033 ,  A61B5/004 ,  A61B6/52 ,  A61B6/5211 ,  A61B6/5229 ,  A61N5/103 ,  A61N5/1039 ,  G06T7/12 ,  G06T2207/10072 ,  G06T2207/30096

Abstract: A radiation therapy system includes a diagnostic image scanner (12) which acquires a multidimensional dataset of a subject that is reconstructed into at least one image representation of an object of interest. An image processing apparatus (72), of radiation therapy system, includes a segmentation unit (74) which identifies a surface contour of the object of interest, or other critical structures. A masking unit (82) determines a non-constant margin, based on the identified surface contour and appends the determined non-constant margin to the identified surface contour. The non-constant margin is based on at least one of anisotropic motion, surface morphology, positional uncertainty, proximity to other organs, and probability of dose distribution. A planning processor (70) generates a radiation therapy plan which limits the delivery of therapeutic radiation to anatomy associated with the surface contour and appended non-constant margin. A radiation delivery system (40) delivers therapeutic radiation according to the generated plan.

Abstract translation: 一种放射治疗系统包括诊断图像扫描器（12），该诊断图像扫描仪（12）获取将被重建为感兴趣对象的至少一个图像表示的被摄体的多维数据集。 放射治疗系统的图像处理装置（72）包括识别感兴趣对象的表面轮廓或其他关键结构的分割单元（74）。 掩蔽单元（82）基于所识别的表面轮廓确定非恒定余量，并将所确定的不恒定余量附加到所识别的表面轮廓。 非恒定余量基于各向异性运动，表面形态，位置不确定性，与其他器官的接近度以及剂量分布概率中的至少一个。 规划处理器（70）产生辐射治疗计划，其限制将治疗辐射递送到与表面轮廓相关联的解剖结构和附加的非恒定边缘。 辐射递送系统（40）根据生成的计划递送治疗辐射。

公开(公告)号：US20110103551A1

公开(公告)日：2011-05-05

申请号：US11573564

申请日：2005-07-28

Applicant: Matthieu Bal ,  Lothar Spies ,  Todd McNutt

Inventor： Matthieu Bal ,  Lothar Spies ,  Todd McNutt

IPC: A61N5/10

CPC classification number: A61N5/103 ,  A61N5/1031 ,  A61N2005/1061 ,  G06F19/00 ,  G06F19/3481

Abstract: In a radiation therapy method, one or more planning images are acquired (102) of a subject. Features of at least malignant tissue are contoured in the one or more planning images to produce one or more initial feature contours. One or more treatment images of the subject are acquired (114). The one or more initial feature contours are updated (122) based on the one or more treatment images. Radiation treatment parameters are optimized (126) based upon the updated one or more feature contours. Radiation treatment of the subject is performed (130) using the optimized parameters.

Abstract translation: 在放射治疗方法中，获取对象的一个​​或多个规划图像（102）。 至少恶性组织的特征在一个或多个规划图像中具有轮廓，以产生一个或多个初始特征轮廓。 获取对象的一个​​或多个处理图像（114）。 一个或多个初始特征轮廓基于一个或多个治疗图像被更新（122）。 基于更新的一个或多个特征轮廓对辐射处理参数进行优化（126）。 使用优化的参数进行受试者的放射治疗（130）。