公开(公告)号：US08103609B2

公开(公告)日：2012-01-24

申请号：US12067481

申请日：2006-09-13

Applicant: Alexander Fischer ,  Lothar Spies

Inventor： Alexander Fischer ,  Lothar Spies

IPC: G06F17/00 ,  G06N5/02

CPC classification number: G06T7/0012 ,  A61B5/055 ,  G01R33/5608 ,  G06K9/3233 ,  G06K2209/05 ,  G06T7/11 ,  G06T2207/30004

Abstract: A system, apparatus, and method are based on a priori knowledge of the shape of the input function for defining an input region-if-interest (ROI) in pharmacokinetic modeling. Kinetic parameter estimation requires knowledge of tracer input activity and the present invention provides an automatic way to define an ROI for estimation of an input function that takes into account a priori knowledge of the shape of the input function based on an administered dose.

Abstract translation: 系统，装置和方法基于用于在药代动力学建模中定义输入区域 - 如果兴趣（ROI）的输入函数的形状的先验知识。 动力学参数估计需要了解示踪剂输入活动的知识，并且本发明提供了一种自动方式来定义用于估计输入功能的ROI，其基于施用的剂量考虑到输入功能的形状的先验知识。

公开(公告)号：US08064672B2

公开(公告)日：2011-11-22

申请号：US12088088

申请日：2006-09-15

Applicant: Manoj Narayanan ,  Bart Jacob Bakker ,  Daniel Gagnon ,  Alexander Fischer ,  Lothar Spies

Inventor： Manoj Narayanan ,  Bart Jacob Bakker ,  Daniel Gagnon ,  Alexander Fischer ,  Lothar Spies

IPC: G06K9/00

CPC classification number: A61B6/00 ,  A61B6/037

Abstract: An imaging system (10) comprises a data device (30), which controls radiation data acquisition from a subject positioned in an examination region (18) for an examination. A rebinning processor (40) bins the acquired data periodically into a histogram (42). A transform (70) transforms the histogram (42) into individual independent or uncorrelated components, each component including a signal content and a noise content. A stopping determining device (52) compares an aspect of at least one selected component to a predetermined threshold (TH) and, based on the comparison, terminates the data acquisition.

Abstract translation: 成像系统（10）包括数据装置（30），其控制从位于检查区域（18）中的被摄体进行检查的辐射数据采集。 重组处理器（40）将获取的数据周期性地存储到直方图（42）中。 变换（70）将直方图（42）变换为独立的或不相关的分量，每个分量包括信号内容和噪声内容。 停止确定装置（52）将至少一个所选择的组件的方面与预定阈值（TH）进行比较，并且基于该比较，终止数据采集。

公开(公告)号：US20100201686A1

公开(公告)日：2010-08-12

申请号：US12671244

申请日：2007-08-03

Applicant: Timo Paulus ,  Alexander Fischer ,  Lothar Spies

Inventor： Timo Paulus ,  Alexander Fischer ,  Lothar Spies

IPC: G06T17/00

CPC classification number: H04L51/14

Abstract: Methods and systems for interworking in messaging systems are described. An event store can be accessible by different dispatchers associated with different message servers. The dispatchers may be co-located with the event store or non co-located with the event store.

Abstract translation: 描述了消息系统中互通的方法和系统。 可以通过与不同消息服务器相关联的不同调度器访问事件存储。 调度员可以与事件存储共同定位，也可以与事件存储不同。

公开(公告)号：US20080228686A1

公开(公告)日：2008-09-18

申请号：US12067481

申请日：2006-09-13

Applicant: Alexander Fischer ,  Lothar Spies

Inventor： Alexander Fischer ,  Lothar Spies

IPC: G06N5/02

CPC classification number: G06T7/0012 ,  A61B5/055 ,  G01R33/5608 ,  G06K9/3233 ,  G06K2209/05 ,  G06T7/11 ,  G06T2207/30004

Abstract: The present invention provides a system, apparatus, and method that are based on a priori knowledge of the shape of the input function for defining an input region-if-interest (ROI) in pharmacokinetic modeling. Kinetic parameter estimation requires knowledge of tracer input activity and the present invention provides an automatic way to define an ROI for estimation of an input function that takes into account a priori knowledge of the shape of the input function based on an administered dose. As a result of the application of the present invention to existing imaging analysis systems, there is a reduction in the amount of manual interaction needed and operator dependence is thereby reduced in the evaluation of dynamic procedures.

Abstract translation: 本发明提供一种系统，装置和方法，其基于用于在药代动力学建模中定义输入区域 - 如果兴趣（ROI）的输入函数的形状的先验知识。 动力学参数估计需要了解示踪剂输入活动的知识，并且本发明提供了一种自动方式来定义用于估计输入功能的ROI，其基于施用的剂量考虑到输入功能的形状的先验知识。 作为将本发明应用于现有成像分析系统的结果，在动态过程的评估中减少了所需的手动交互量，从而减少了操作者依赖性。

公开(公告)号：US08170308B2

公开(公告)日：2012-05-01

申请号：US12300341

申请日：2007-05-01

Applicant: Alexander Fischer ,  Lothar Spies ,  Carsten Meyer

Inventor： Alexander Fischer ,  Lothar Spies ,  Carsten Meyer

IPC: G06K9/00

CPC classification number: G06T7/11 ,  G06K9/6218 ,  G06T2207/10104 ,  G06T2207/20016 ,  G06T2207/20021 ,  G06T2207/30096

Abstract: A method for use in functional medical imaging includes adaptively partitioning functional imaging data as a function of a spatially varying error model. The functional image data is partitioned according to an optimization strategy. The data may be visualized or used to plan a course of treatment. In one implementation, the image data is partitioned so as to vary its spatial resolution. In another, the number of clusters is varied based on the error model.

Abstract translation: 用于功能医学成像的方法包括根据空间变化的误差模型自适应地划分功能成像数据。 功能图像数据根据优化策略进行分区。 数据可以被可视化或用于计划治疗过程。 在一个实现中，图像数据被分割以改变其空间分辨率。 另一方面，群集的数量根据误差模型而变化。

公开(公告)号：US20090264728A1

公开(公告)日：2009-10-22

申请号：US12375430

申请日：2007-07-23

Applicant: Alexander Fischer ,  Lothar Spies

Inventor： Alexander Fischer ,  Lothar Spies

IPC: A61B6/00 ,  A61N5/00

Abstract: A therapy system (100) includes an imager (102), a therapy planner (104), and a therapy device (106). The therapy planner (104) includes a therapy prescription apparatus (118) which calculates a desired therapy (D) to be applied to a human patient or other subject. The therapy prescription system (118) uses a pathology model (122) and a patient-specific biological parameter history (124) to optimize the applied therapy.

Abstract translation: 治疗系统（100）包括成像器（102），治疗计划器（104）和治疗装置（106）。 治疗计划器（104）包括治疗处方设备（118），其计算要应用于人类患者或其他受试者的期望治疗（D）。 治疗处方系统（118）使用病理模型（122）和患者特异性生物参数历史（124）来优化应用治疗。

公开(公告)号：US20090208075A1

公开(公告)日：2009-08-20

申请号：US12300341

申请日：2007-05-01

Applicant: Alexander Fischer ,  Lothar Spies ,  Carsten Meyer

Inventor： Alexander Fischer ,  Lothar Spies ,  Carsten Meyer

IPC: G06K9/00 ,  G06N5/02

CPC classification number: G06T7/11 ,  G06K9/6218 ,  G06T2207/10104 ,  G06T2207/20016 ,  G06T2207/20021 ,  G06T2207/30096

Abstract: A method for use in functional medical imaging includes adaptively partitioning functional imaging data as a function of a spatially varying error model. The functional image data is partitioned according to an optimization strategy. The data may be visualized or used to plan a course of treatment. In one implementation, the image data is partitioned so as to vary its spatial resolution. In another, the number of clusters is varied based on the error model.

Abstract translation: 用于功能医学成像的方法包括根据空间变化的误差模型自适应地划分功能成像数据。 功能图像数据根据优化策略进行分区。 数据可以被可视化或用于计划治疗过程。 在一个实现中，图像数据被分割以改变其空间分辨率。 另一方面，群集的数量根据误差模型而变化。

公开(公告)号：US20090171183A1

公开(公告)日：2009-07-02

申请号：US12088088

申请日：2006-09-15

Applicant: Manoj Narayanan ,  Bart Jacob Bakker ,  Daniel Gagnon ,  Alexander Fischer ,  Lothar Spies

Inventor： Manoj Narayanan ,  Bart Jacob Bakker ,  Daniel Gagnon ,  Alexander Fischer ,  Lothar Spies

IPC: A61B5/05 ,  G06F19/00

CPC classification number: A61B6/00 ,  A61B6/037

Abstract: An imaging system (10) comprises a data device (30), which controls radiation data acquisition from a subject positioned in an examination region (18) for an examination. A rebinning processor (40) bins the acquired data periodically into a histogram (42). A transform (70) transforms the histogram (42) into individual independent or uncorrelated components, each component including a signal content and a noise content. A stopping determining device (52) compares an aspect of at least one selected component to a predetermined threshold (TH) and, based on the comparison, terminates the data acquisition.

Abstract translation: 成像系统（10）包括数据装置（30），其控制从位于检查区域（18）中的被摄体进行检查的辐射数据采集。 重组处理器（40）将获取的数据周期性地存储到直方图（42）中。 变换（70）将直方图（42）变换为独立的或不相关的分量，每个分量包括信号内容和噪声内容。 停止确定装置（52）将至少一个所选择的组件的方面与预定阈值（TH）进行比较，并且基于该比较，终止数据采集。

公开(公告)号：US07787669B2

公开(公告)日：2010-08-31

申请号：US10543567

申请日：2004-01-19

Applicant: Henrik Botterweck ,  Lothar Spies

Inventor： Henrik Botterweck ,  Lothar Spies

IPC: G06K9/00

CPC classification number: A61B6/032 ,  A61N5/1031 ,  Y10S128/922

Abstract: In order to reduce an x-ray dose applied to a patient, it is necessary to know the dose absorbed by the patient. According to the present invention, there is provided a method of determining a local patient dose applied to a patient where after the reconstruction of the scan data into a diagnostic image, the scan data are backprojected into the patient volume, using the attenuation information of the diagnostic image to form a spatially varying photon fluence map. In parallel, the diagnostic image is segmented into anatomical structures to which dose-weighting factors are assigned. The locally absorbed dose is then calculated on the basis of the fluence map and the corresponding dose weights.

Abstract translation: 为了减少施加到患者的x射线剂量，需要知道患者吸收的剂量。 根据本发明，提供了一种确定施用于患者的局部患者剂量的方法，其中在将扫描数据重建为诊断图像之后，使用所述扫描数据的衰减信息将扫描数据反向投影到患者体积中 诊断图像形成空间变化的光子注量图。 并行地，诊断图像被分割成分配给剂量加权因子的解剖结构。 然后根据注量图和相应的剂量重量计算局部吸收剂量。

公开(公告)号：US08617072B2

公开(公告)日：2013-12-31

申请号：US11569437

申请日：2005-05-20

Applicant: Dragos-Nicolae Peligrad ,  Lothar Spies ,  Timo Paulus

Inventor： Dragos-Nicolae Peligrad ,  Lothar Spies ,  Timo Paulus

IPC: A61B5/00

CPC classification number: G06F19/321 ,  G06F19/00 ,  G16H10/40

Abstract: The invention relates to a general composite compartmental model and a compartmental analysis procedure to extract non-invasively the concentration (Cp) of the imaging agent in plasma (301), in metabolites (304, 504) and in blood elements (303) (like red cells, platelets, plasma protein etc.) from time signal curves measured within a reference tissue region (200). This is made possible by deploying an injection function (SINJ(t)) as input which models the amount of imaging agent administered to the patient as a function of time. The invention allows the presentation of the plasma input function to the medical practitioner without the need for invasively drawing blood samples.

Abstract translation: 本发明涉及一般的复合区室模型和隔室分析程序，其非侵入性地提取血浆（301），代谢物（304,504）和血液元件（303）中的成像剂的浓度（Cp）（如 红细胞，血小板，血浆蛋白等）从参考组织区域（200）中测量的时间信号曲线。 这是通过部署注射功能（SINJ（t））作为对作为时间的函数对患者施用的成像剂的量进行建模的输入而实现的。 本发明允许向医生介绍等离子体输入功能，而不需要侵入性地抽取血液样本。