公开(公告)号：US20180319750A1

公开(公告)日：2018-11-08

申请号：US16035738

申请日：2018-07-16

Applicant: Dow AgroSciences LLC

Inventor： Gregory T. Whiteker ,  Nakyen Choy ,  Peter Borromeo ,  Nicholas R. Babij ,  Gary Roth ,  Patrick S. Hanley ,  Matthias S. Ober ,  Tina Staton ,  Daniel I. Knueppel ,  Grant Von Wald ,  Nicole Hough

IPC: C07D213/81 ,  C07C271/22 ,  C07C227/18 ,  C07C229/08

CPC classification number: C07D213/81 ,  C07C227/18 ,  C07C229/08 ,  C07C269/06 ,  C07C271/22

Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.

公开(公告)号：US09951018B2

公开(公告)日：2018-04-24

申请号：US15443446

申请日：2017-02-27

Applicant: Dow AgroSciences LLC

Inventor： Patrick S. Hanley ,  Nakyen Choy ,  Thomas L. Siddall ,  Gregory T. Whiteker

IPC: C07D213/803 ,  C07D213/84

CPC classification number: C07D213/803 ,  C07D213/84

Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 2-hydroxypicolinonitrile in a series of chemical steps selected from chlorination, chloro substitution, nitrile hydrolysis and chloro reduction.

公开(公告)号：US20180009755A1

公开(公告)日：2018-01-11

申请号：US15642653

申请日：2017-07-06

Applicant: Dow AgroSciences LLC

Inventor： Gregory T. Whiteker ,  Nakyen Choy ,  Peter Borromeo ,  Nicholas R. Babij ,  Gary Roth ,  Patrick S. Hanley ,  Matthias S. Ober ,  Tina Staton ,  Daniel I. Knueppel ,  Grant Von Wald ,  Nicole Hough

IPC: C07D213/81 ,  C07C227/18

CPC classification number: C07D213/81 ,  C07C227/18 ,  C07C229/08 ,  C07C271/22

Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.

公开(公告)号：US20170247330A1

公开(公告)日：2017-08-31

申请号：US15443446

申请日：2017-02-27

Applicant: Dow AgroSciences LLC

Inventor： Patrick S. Hanley ,  Nakyen Choy ,  Thomas L. Siddall ,  Gregory T. Whiteker

IPC: C07D213/803 ,  C07D213/84

CPC classification number: C07D213/803 ,  C07D213/84

Abstract: 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 2-hydroxypicolinonitrile in a series of chemical steps selected from chlorination, chloro substitution, nitrile hydrolysis and chloro reduction.

公开(公告)号：US20170174582A1

公开(公告)日：2017-06-22

申请号：US15129282

申请日：2015-03-27

Applicant: Dow Global Technologies LLC ,  Dow AgroSciences LLC

Inventor： Patrick S. Hanley ,  Gregory T. Whiteker ,  Matthias S. Ober ,  William J. Kruper, Jr. ,  Arkady L. Krasovskiy

IPC: C07C1/32 ,  C07B37/04 ,  C07D213/16 ,  C07C22/04 ,  C07C233/00 ,  C07C211/45 ,  C07C22/08 ,  C07C15/14 ,  C07D263/54

CPC classification number: C07C1/322 ,  C07B37/04 ,  C07C1/321 ,  C07C15/14 ,  C07C17/263 ,  C07C22/04 ,  C07C22/08 ,  C07C41/30 ,  C07C45/70 ,  C07C67/343 ,  C07C211/45 ,  C07C231/12 ,  C07C233/00 ,  C07C253/30 ,  C07C2531/22 ,  C07C2531/24 ,  C07C2531/28 ,  C07D213/127 ,  C07D213/16 ,  C07D263/54 ,  C07C233/65 ,  C07C255/50 ,  C07C43/205 ,  C07C49/784 ,  C07C69/76

Abstract: In one aspect, there is provided a method of coupling a first aromatic compound having a fluorosulfonate substituent to a second aromatic compound having a boron-containing substituent. In another aspect, there is provided a method of coupling a first aromatic compound having a hydroxyl substituent to a second aromatic compound having a boron-containing substituent in a one-pot reaction.

公开(公告)号：US10358423B2

公开(公告)日：2019-07-23

申请号：US16035738

申请日：2018-07-16

Applicant: Dow AgroSciences LLC

Inventor： Gregory T. Whiteker ,  Nakyen Choy ,  Peter Borromeo ,  Nicholas R. Babij ,  Gary Roth ,  Patrick S. Hanley ,  Matthias S. Ober ,  Tina Staton ,  Daniel I. Knueppel ,  Grant Von Wald ,  Nicole Hough

IPC: C07C227/18 ,  C07C229/08 ,  C07C269/06 ,  C07C271/22 ,  C07D213/81

Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.

公开(公告)号：US20190177265A1

公开(公告)日：2019-06-13

申请号：US16271008

申请日：2019-02-08

Applicant: Dow AgroSciences LLC

Inventor： Patrick S. Hanley ,  Thomas P. Clark ,  Matthias S. Ober ,  William J. Kruper

IPC: C07C209/18 ,  C07D317/66 ,  C07C209/66 ,  B01J31/22 ,  C07D295/023 ,  C07C213/02 ,  C07B43/04 ,  C07D295/033 ,  C07D317/58 ,  C07D213/74 ,  C07C253/30 ,  C07C231/12 ,  C07C227/08 ,  C07C221/00

Abstract: The present disclosure describes a method of coupling a first compound to a second compound, the method comprising: providing the first compound having a fluorosulfonate substituent; providing the second compound comprising an amine; and reacting the first compound and the second compound in a reaction mixture, the reaction mixture including a catalyst having at least one group 10 atom, the reaction mixture under conditions effective to couple the first compound to the second compound. The present disclosure further describes a one-pot method for coupling a first compound to a second compound.

公开(公告)号：US10040764B2

公开(公告)日：2018-08-07

申请号：US15642653

申请日：2017-07-06

Applicant: Dow AgroSciences LLC

Inventor： Gregory T. Whiteker ,  Nakyen Choy ,  Peter Borromeo ,  Nicholas R. Babij ,  Gary Roth ,  Patrick S. Hanley ,  Matthias S. Ober ,  Tina Staton ,  Daniel I. Knueppel ,  Grant Von Wald ,  Nicole Hough

IPC: C07C227/18 ,  C07D213/81

CPC classification number: C07D213/81 ,  C07C227/18 ,  C07C229/08 ,  C07C269/06 ,  C07C271/22

Abstract: A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic acid or 4-methoxy-3-hydroxypicolinic acid with a key 2-aminopropanoate ester derived from a 1,1-bis(4-fluorophenyl)propane-1,2-diol.